Nwiss 🇸🇪🇪🇸🇺🇸🇬🇧🇪🇺

I felt it clearly, the damn virus never left my body. 2+ years later - why is #viralpersistence still not properly investigated in #LongCovid ?! UNFATHOMABLE.

We’re proud to have Dr. Steve Deeks, who has garnered decades of experience researching HIV diagnostics & treatments, leading PolyBio’s VIPER diagnostics program for Long Covid. Said Dr. Deeks, “Having witnessed how a single test can transform a complex disease like HIV, I am fully committed to doing my part to develop tests for Long COVID. Validated diagnostics will allow us to run smarter, more targeted trials - and ultimately deliver effective treatments to patients faster.”

@surf4children Best of luck ✨🙌🏼✨💫

Good morning, when I say "I'm doing my best to apply to funds for #longcovid #mecfs" this is what I mean :) horizon applications mood on! Who is wishing me luck?

A review of 49 MRI studies shows that COVID-19 is associated with structural and functional brain changes. ➡️ Abnormalities are most commonly seen in the frontal, temporal, and parietal lobes, as well as the limbic system and subcortical regions. ➡️ These findings suggest widespread brain involvement, not limited to a single area. ➡️ The changes may explain both acute neurological symptoms and long-term effects (LongCOVID). 👉 COVID-19 is not just a respiratory disease—it has measurable, widespread effects on the brain academic.oup.com/cercor/article…

"COVID-19 patients show structural and functional changes in multiple cortical and subcortical regions compared to healthy subjects.. alterations were predominantly in frontal regions, temporal regions, parietal regions, limbic system, and subcortical nuclei. The microstructural and functional alterations in these regions may underlie impairment of a number of neurocognitive functions.. For acute COVID-19, whole-brain studies indicate lower GMV and functional activity (lower functional connectivity or ALFF), disruption of white matter fiber structures (lower FA or tract length), and increased tissue diffusivity (higher apparent diffusion coefficient or MD).. brain changes in long COVID-19 may be symptom-dependent, involving multiple neuropathological mechanisms, and do not present a uniform, stable global pattern.." Alterations in the brain cause alterations in personality. 'Widespread structural and functional brain alterations in COVID-19: a systematic review of MRI studies' academic.oup.com/cercor/article…

Chronically ill parents, were you diagnosed before or after having kids? Knowing what you know now, would you still make the same decision? If you’re open to it, I’d really like to hear your experience.

@ThePOTSPostman This is such an important topic 💔🖤 I was diagnosed with ME while pregnant with my second child. The capacity of the other parent + a strong network makes all the difference. I had neither, and my daughters have suffered. It’s so extremely painful witness.

Excited to get this out in preprint: triple-blind, placebo-controlled microtesla magnetic therapy (MMT) is safe, feasible and effective in reducing cognitive impairment in people with #LongCOVID. I get excited about interventions for cognitive symptoms medrxiv.org/content/10.648… 1/

One of the most interesting theories in ME/CFS - and in Long Covid too - is the IDO metabolic trap idea from Robert Phair and Ron Davis. Not because it’s proven, but because it’s one of the few theories that tries to explain why people get stuck.

Covid has led to an increase in #MECFS. In Germany, numbers have gone from ~250,000 to over 600,000 since the start of the pandemic. It’s been around for decades, yet many patients still aren’t believed and are given harmful advice by doctors, as one patient reports.

VIPER could change how we understand these illnesses for years to come. If more people pay attention and help fund it, those small steps could turn into real breakthroughs.

Our paper is (finally) out in @CellRepMed: antibodies from #LongCOVID patients transfer symptoms to mice, pointing to a potential causal role for autoimmunity: cell.com/cell-reports-m… @amsterdamumc @UMCUtrecht 1/12

Breaking: PolyBio Research Foundation today announced the launch of VIPER, the first large-scale program designed to rigorously validate diagnostic tests that measure SARS-CoV-2 persistence and other biological drivers of Long COVID: prnewswire.com/news-releases/…

ME: Swansea man was active but now he can't walk or talk at 28 bbc.com/news/articles/…

I’m talking to the NIH next week about what it’s like to live with Long COVID. What’s the one thing people still don’t understand and the part that really needs to be seen and said out loud?

University of Valladolid, 23 patients, immune changes during acute COVID and 3 months later may flag who develops Long COVID, with early innate disruption and lasting T cell shifts standing out as key clues. journalofinfection.com/article/S0163-…

🔥This landmark study 🧵 reveals that LC could originate in the first hours of infection via dysregulated innate immunity in dendritic and gamma-delta T cells, leading possible to a lasting T-cell reprogramming and maybe a chronic viral reactivation! 👇 Thanks @ZdenekVrozina!

From a study of 49 patients with post COVID-19 condition (80% female) and 48 healthy controls, "Patients with post COVID-19 condition exhibited significant deficits of attention, executive functions, phonemic and semantic fluency, verbal learning and episodic and visuospatial memory.. Thalamic volumes were significantly reduced in patients with post COVID-19 condition.. Fractal dimensionality analyses showed increased complexity in the occipital lobes and hippocampal fimbriae, and reduced complexity in the thalamus bilaterally in patients.. [In conclusion,] analyses revealed reduced thalamic volumes and reduced thalamic complexity that was associated with fatigue severity [among patients with post COVID-19 condition]." SARS-CoV-2 is a brain transformer. 'Association of structural brain changes with cognitive deficits and fatigue in patients with post COVID-19 condition' academic.oup.com/braincomms/adv…

Immune deficiency from viral infection is different than that caused by genetics. I was diagnosed and evaluated for primary immune deficiency prior to COVID. I had low IgA and IgG, low antibody production and retention, as well as potentially low interferon 1. I did not have low lymphocytes of any type; my T and B cells are naturally normal. There are documented cases of people with my PID CVID who have HIV and AIDS from that infection. Lymphocytopenia/AIDS from a virus is not the same as PID. They require separate testing and treatment. They don't appear the same on lab diagnostics. CVID is treated with immuneglobulin and HIV requires antivirals. In my case, I was already on IG and antivirals were needed to treat the immune deficiency from chronic SARS-COV2. #COVAIDS share.google/aimode/tWGDuE4…

The study supports concern that long COVID may be associated with an increased risk of mild cognitive impairment, including impairment with features resembling early Alzheimer’s disease🧵

Holy moly, got Chat-GPT to state that all countries wrt Covid are doing it wrong and are not being serious about disease control the way they should. And I did not even prod it in that direction, except challenging it about "focused protection".