GuccioneLab

Excellent article that highlights the contribution of NIH grant funding to fueling economic activity. An important read especially for non- scientist to understand how disruptive NIH cuts are both to medicine and to the economy.

Awesome opportunity

Strong article from Tom Maniatis, head of the NY Genome Center, on the history of the NIH and its role in maintaining U.S. scientific leadership. Safeguarding the future of biomedical science in the United States: Cell cell.com/cell/fulltext/…

Here we characterize PRDM10 as an essential maternal transcription factor and dissect its role in regulating oocyte maturarion and oocyte-to-embryo transition! On to the next! Congrats to @meschmi the true mastermind behind this work! nature.com/articles/s4146…

New in @Nature: Human-correlated genetic models identify precision therapy for liver cancer rdcu.be/ebdH2 Josep Llovet and team @IcahnMountSinai validated the molecular profiles of preclinical models against human HCC data. #livercancer #HCC

Myeloid Cell Checkpoints: Ido Amit, Florent Ginhoux, and Miriam Merad addressed this topic in a symposium at the inaugural AACR IO Conference on Discovery and Innovation in Cancer Immunology. #AACRIO25 @IdoAmitLab @FGinhoux @MiriamMerad

Now more than ever the message is: this research can soon have an impact on people’s lives. Do not defund science!Proud of this collab with @kimioishi and the whole #RNA modulation for therapeutics Lab (kudos to JinRong in particular!) journal-of-hepatology.eu/article/S0168-…

"More than 99% of new drug approvals (2010-2019) were funded by NIH. Why dismantle the engine that made the U.S. a world leader in innovation and drug development ? #DoNotDefundScience jamanetwork.com/journals/jama-…

Exciting tech advance 4 cancer research: FFPE-CUTAC enables phenotype queries from archived FFPE tissues. This finds a striking correlation between hypertranscription of histones (but not ribosomal genes) & chromosome arm losses, hence, cancer evolution. science.org/doi/10.1126/sc…

The AACR is deeply concerned that the Administration’s recent actions are threatening NIH and its mission to accelerate progress for patients with cancer and other diseases that afflict millions of Americans. We urge Congress to restore stability to NIH: brnw.ch/21wQMO3

@kylechasse An egg today is better than a chicken tomorrow? The impact on the health system will be catastrophic for Americans, regardless or what they voted and they will see people they love die instead of being cured. But this will happen in 5 years, so it’s easier to enjoy a vacation now

🇺🇸 MUSK'S $5,000 DOGE DIVIDEND?! 🚨 Elon Musk considers sending EVERY American a $5,000 check—funded by DOGE savings! Says he’ll ask Trump about the plan. Government efficiency = Dogecoin payouts?! WHAT A TIME TO BE ALIVE. 🤯

@Free_of_CANCER Interested to learn more about the approach. Familiar with DAOs and the crypto ecosystem. Please reach out to discuss this further.

🚀 The First Wave Begins! 🚀 We’ve officially invited scientists & researchers worldwide to submit their proposals for groundbreaking cancer research. This is just the beginning—more invitations will follow as we build a decentralized future for cancer research, free from bureaucracy & funding barriers. If you’ve received an email from us, we hope you’ll join the movement. 💡 Imagine a world Free of CANCER. #FreeOfCancer #DeSci #CancerResearch #CANCER

csr.nih.gov/RevPanelsAndDa… link to check whether any study section is still happening. If NIH cannot post the study section on the national register then it cannot formally happen. The ripple effects can be devastating if no new funding is awarded.

What an amazing cover! Congrats ⁦@glogliiita⁩!!

Amazing to see this out. A mechanistic study with deep implications for future clinical work. Cannot be prouder ⁦@Sleemmzz⁩ A huge thanks to all our collaborators ⁦@ggargiul_2020⁩ @nickbar36316207 ⁦@owen_sansom⁩ ⁦@NIHFunding⁩ nature.com/articles/s4158…

It's out! If you look for a reliable reporter system for your Nucleic Acid Therapeutics needs, we got you covered! The NATURA system is available to the community on Addgene. Congrats to Tommaso Tabaglio for leading this incredible effort! sciencedirect.com/science/articl…

Fantastic #PhD opportunity in #DataScience at @Sissaschool in #Triest, #Italy. Applications from #Bioinformatics to #cosmology and #Neuroscience. Deadline Feb14! datascience.sissa.it/how-to-apply

End-of-the-year preprint 🧵! Ever wondered how a cancer driven by a single mutant oncogene becomes molecularly & cellularly heterogeneous? Why metastases share drivers w/primary tumors but are more aggressive?

@raimondi_ivan Very cool!

🧬 We’re excited to introduce D&D-seq, a single-cell technology that maps DNA:Protein interactions through molecular footprinting.. Check it out here: biorxiv.org/content/10.110… #Genomics #Epigenetics

@OstuniLab Finally an interesting paper on phase separation

The science of pasta cacio e pepe 🇮🇹👨‍🍳 "Finally, we present a scientifically optimized recipe based on our findings, enabling a consistently flawless execution of this classic dish." Applied science at its best, with real-world impact arxiv.org/abs/2501.00536