Hadley Miller

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Hadley Miller

Hadley Miller

@HadleyMiller8

Science Enthusiast / Leader at 10x Genomics / Single Cell & Spatial Technologist / Family Man

Dallas, TX Katılım Ocak 2018
3.2K Takip Edilen1.1K Takipçiler
Hadley Miller retweetledi
Allen Institute
Allen Institute@AllenInstitute·
With @10xGenomics and @thedohertyinst, we've mapped gene activity in human intestinal and skin tissue at unprecedented resolution. To test the new Atera platform, we studied small pieces of each tissue. Data from each are now publicly available. 🔗 More: bit.ly/4dUsVCg
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Bo Wang
Bo Wang@BoWang87·
Quite remarkable story to read! I find how single-cell RNAseq was used for personalized diagnosis is quite intriguing! What Sid has done — tumor biopsies at T1, T2, T3 with single-cell resolution, paired with CD3+ PBMC tracking at eight timepoints — is the kind of longitudinal dataset that cancer researchers dream about and almost never get in a clinical context. This is what precision oncology actually looks like when you take it seriously. Not a one-time genomic snapshot, but a dynamic molecular portrait updating alongside the disease.
Sebastian Caliri@SebastianCaliri

The full deck on Sid’s cancer approach is here: sytse.com/cancer/ Worth a read. Raw data for download is also available and linked in the deck

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Xin Jin, PhD
Xin Jin, PhD@xinjin·
📢 Preprint: we present a whole-mouse-brain in vivo Perturb-seq atlas, 7.7 million cells, 1947 disease-associated perturbations, moving toward direct readout of how human genetics rewires cell states & circuits in vivo. Grateful for the Team! @NVIDIAHealth biorxiv.org/content/10.648…
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Manav Pathania | @manavpathania.bsky.social
Manav Pathania | @manavpathania.bsky.social@Pathania_Lab·
We're seeking to fill two roles: a postdoc and a research assistant. Both will focus on resistance mechanisms in brain tumour models using various approaches (in vivo, spatial omics, CRISPR). Please apply if this aligns with your previous experience! shorturl.at/hZ6mG
GIF
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Moritz Schäfer
Moritz Schäfer@muronglizi·
Want to analyze your single-cell data, but don't like to deal with code? 🧬 Good news: CellWhisperer now runs on your MacBook! 💻 Get your single-cell AI assistant running in under 5 minutes.⏱️ Made with ❤️ @BockLab
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Naftali Kaminski
Naftali Kaminski@KaminskiMed·
Always exciting to see a paper in its final version, and especially when the first author is an MD/PhD student entering last clinical year and it is the Lung Aging Cell Atlas!! nature.com/articles/s4146…
Naftali Kaminski tweet media
Naftali Kaminski@KaminskiMed

The Normal Aging Lung Single Cell Atlas is finally out!!! Lung aging is cell-type dyssynchronous, with alveolar epithelial & endothelial cells showing ⬆️ changes in gene expression, somatic mutations burden, transcriptional entropy. 👏🏼 @ruben_deman 👏🏼 nature.com/articles/s4146…...

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Rahul Satija
Rahul Satija@satijalab·
Inspired by @JswLab, we generated a mini Genome-wide Perturb-seq, using just two 10x lanes (!). Far too much data for one tweet (or one Figure), but it works beautifully. The ability to assess the molecular function of every gene in an afternoon is mind-boggling
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Dylan Webster
Dylan Webster@DylanPWebster·
It's amazing to see what awesome scientists can achieve with @10xGenomics GEM-X Flex. ProPer-seq highlights exactly how Flex’s probe-based, fixed-cell workflow overcomes cost and scale barriers—unlocking the massive datasets needed for large scale perturbation screens as an input to #virtualcell models. #singlecell #genomics
Elliot Hershberg@ElliotHershberg

More exceptional technology from the Arc Institute: "ProPer-seq faithfully reproduces gold-standard perturb-seq phenotypes while achieving 4-fold cost reduction and 50% increased gene detection per cell." Seems like a big improvement (in cost and resolution) for one of the most central methods in modern functional genomics. The required inputs to scale "virtual cell" models continue to plummet in cost...

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Dr Rachael Zemek
Dr Rachael Zemek@RachaelZemek·
I got to put my skills in spatial transcriptomics to work on something other than cancer!
JCI insight@JCI_insight

How does #HSV-2 shedding affect immunity in female genital tract tissues? Here, Jennifer M. Lund @JennyLund15 & team @fredhutch report immune cells mobilize and co-localize in the vaginal epithelium, expressing cytotoxic, inflammatory and immunoregulatory genes that may promote tissue homeostasis to limit damage: doi.org/10.1172/jci.in… The image shows visualization of cells on a representative tissue section for spatial transcriptomics.

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Neville Sanjana
Neville Sanjana@nevillesanjana·
Looking for some Thanksgiving reading? 🦃🦃🦃 🚨Check out our new preprint on CRISPore-seq!🚨 Combining pooled CRISPR perturbations with single-cell sequencing has been tremendously powerful... but we are missing a lot with current approaches like Perturb-seq and ECCITE-seq.
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Roth_Lab
Roth_Lab@Roth_Lab·
Excited to present the first major work after starting our lab at Stanford and the Arc this year: CRISPR-All, a unified genetic perturbation language for programming any major type of genetic perturbation simultaneously, in any combination, at genome scale, in human cells.
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Omer Ali Bayraktar
Omer Ali Bayraktar@bayraktar_lab·
Which human brain circuits are implicated in neurodevelopmental conditions? We bridged human genetics, spatial transcriptomics and neurodevelopment to discover the convergence of autism-associated genes in the developing human thalamus! biorxiv.org/content/10.110…
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Anna Nam
Anna Nam@AnnaEnim·
Excited to introduce GoT-Multi, out at @CellGenomics: cell.com/cell-genomics/…! Developed together with the single cell wizard @LGMartelotto, GoT-Multi is a next gen single cell multi-omics - multiplexed genotyping in transcriptomes compatible with FFPE samples.
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Keşfet

@10xGenomics @TheDohertyInst @MSKCancerCenter @SydneyBlattman @NabihMaslah @AustinAVarela @dana_peer @NVIDIAHealth