Jake Perry

@harryh @AmanitaFugax

@AmanitaFugax Throw in pro immigration and pro policing and baby, you got a stew going.

Pro Waymo, pro data center, pro nuclear, pro solar, pro train, anti zoning, pro housing has to be one of the most correct and unelectable combinations in America

ASIMO, 17 years ago, looked so far ahead of its time. It inspired an entire generation of robotics engineers.

@testingham If you get a century of progress in the next decade, how much progress do you get in the decade after that? Presumably it accelerates until you literally bump up against the limits of the natural world.

When economists talk about "post-AGI futures" they mean abundance: 10X growth. When AI people talk about "post-AGI futures" they mean omnipotence: growth until physical limits are hit. A natural question to ask the economists: if AI gets you a century's technological progress in a decade, why will it stop there? Additionally, from the perspective of omnipotence, the economists considerations all start to seem *provincial*. Considerations about redistribution, inequality, democracy, power concentration, dignity, meaning. (This observation comes from me trying to reconcile post-AGI conversations at Lighthaven, and post-AGI conversations at Asilomar)

@molochofficial People yearn for wooden word art for their walls that say things like "Gather" and "Cherish"

Cannot understand the retail niche that Hobby Lobby occupies. It’s simultaneously like TJ Maxx but without clothes and Michaels but without art supplies.

@chuckster455 @Medscape It happened before weight changed in any significant way

@Medscape Because weight loss improved blood flow.

For years, conventional wisdom held that skin improvements among patients on GLP-1 medications were a byproduct of weight loss, which reduces inflammation. But doctors are spotting a much more complex reality — and new research supports their observations. At the University of Pittsburgh Medical Center (UPMC) in Pittsburgh, Pennsylvania, dermatologist Joe K. Tung, MD, MBA, noticed dramatic changes in his patients with psoriasis just starting a GLP-1. Their plaques began “melting away” within 2 days. “That’s too fast for that to be a weight-loss effect,” he said. “The next step for me was just thinking, could this mechanistically be plausible?” More on the findings: mdsc.pe/4aPfzF2

@peterottsjo Terror management is rough. People work so hard to suppress their fear of death that they will fight anyone who threatens to remind them that death is a bad thing.

Headline in The Guardian today. Aging leads to death but fighting it is somehow anti-life. These people. It’s gaslighting, doublespeak, fucking maddening - take your pick. No I didn’t read the thing. It hasn’t earned the right to be read.

@zobotics What would it take to make it happen? Like what resources?

Pittsburgh, the self-proclaimed "robotics capital of the world," could actually pull this off if it didn't misallocate its resources so epically that 99% of CMU grads board a plane to SFO five minutes after graduation.

I've been noticing way less bots in my comments since Fable / GPT 5.6... 💀

@nytmike Release the Epshteyn Files too, I guess

NEW BREAKING: Behind closed doors, a battle has erupted between Trump admin and the law firms that cut deals last year. The firms have lawyered up. DOJ is demanding the firms' leaders sit for depositions. At the center of it all are questions about the role Boris Epshteyn played in the deals w/@DevlinBarrett nytimes.com/2026/07/14/us/…

@EricTopol Makes me wonder whether UV protection for skin actually promotes longevity by not having an extremely large and damaged organ covering your entire body.

Fast aging of more than 1 organ is linked to reduced survival in multiple studies. Slow/normal aging of the brain and immune system, by organ and by cells, are consistently associated with extended healthspan and longevity. erictopol.substack.com/p/medicine-is-…

The most absurd number in CPI? According to the US Government, the cost of health insurance has declined 31% over the last 4 years...

@rennyzucker idk seems like the best time tbh

Dropping Claude for US teachers in July and August is diabolical stuff

@Merridew__ That's totally where this is going, isn't it

@DLHappens @BoringBiz_ Lol, if you disagree just say why. I don’t care enough to answer repeated semantic questions waiting around to hear what you’re building up to.

@ItsJakePerry @BoringBiz_ Exactly. You don't have an argument to support your position.

The FIRE (financial independence retire early) movement has done an immense amount of harm to society This is coming from someone who used to be a believer in FIRE, but I have realized just how much of a fallacy it is, as I have grown older Taking a bunch of high potential income earners and convincing them that their life goal should be to pursue a net worth that allows them to check out of society is immensely damaging to the social fabric Many of these people sit on the upper echelon of office jobs, have built great businesses, or are at the top of their field in their career field They should be inspired to continue doing what they are best at, and ultimately, mentor and give back to the next generation who want to pursue those same goals Instead, many of these FIRE folks become wandering retirees with a meaningless life who are trying to grasp on to money as their north star It is a false sense of security and accomplishment. Becoming wealthy should never be a goal in the first place. It should have always been to pursue something that adds meaning to your own life and to society It is a completely fallacy to believe that retiring will be your source of happiness. More often than not, it has the complete opposite effect

@DLHappens @BoringBiz_

@ItsJakePerry @BoringBiz_ Positive from whose perspective?

@DLHappens @BoringBiz_ Whatever hopefully positive part you play in the world

@ItsJakePerry @BoringBiz_ Contribute to what exactly?

@darrenatter109 @BoringBiz_ Imagine thinking that working a w2 is the only way to contribute to society

@BoringBiz_ Nonsense. There is more to life than work and there are many well paying jobs that are well paying because they are dull. Aspiring to get enough money to leave those jobs is great. It need not be extreme however, not the least spending but also not spending wastefully

@LaurieGreen36 I think it might be something even weirder than either one of those. Preventing or reversing the destructive aging program but still qualitatively different in some ways than your literal body when it was 20.

I've noticed people saying 'age reversal' but not meaning in the literal sense of the term. Will age reversal science bring us back to our true youth and who we were when we were young adults? Or will it just mean feeling younger and healthier when we are old?

@agingroy Reminds me of this m.youtube.com/watch?v=BzAdXy…

Everyone wants to sell peptides, but nobody will fund even a basic clinical trial on them. Wonder why?