Joeri Meijsen

@ToddLencz @SashaGusevPosts This is true indeed but the paper mentions year-of-birth stratification. This forces the comparison of people having undergone the same temporal trends on a population-wide scale. These were then meta-analyzed to mostly account for these (which is an imperfect way) trends.

@SashaGusevPosts As for temporal effects, there may be changes to the way cases were classified over the course of different iterations of ICD, which might inflate the SCZ-BIP correlation and decrease the individual disorder heritability.

I wrote about how polygenic heritable conditions present in families and the liability threshold model. This has some counterintuitive implications for considering the risk of a condition in offspring as well as the impact of multi-generational selection. A 🧵:

@RJStrawbridge I am pretty sure these budget airlines have repeatedly been fined for their incentive/quota-based rejection of hand luggage at the gate. So, it sounds more than plausible to me.

Husbands take, the quarterly finance reports don't look good so they need to boost profits.... Cynical but plausible!

With the #easyjet plus (french) website being broken for over a month, this holiday has already cost us £120 more than it should. Now being charged for hand hand luggage that has been under my seat without problem regularly for the past 7 years?! What a piss take

@dr_appie I just want to see the latest scientific papers! I don't even follow other people but I keep getting spammed on Twitter with political nonesense that from people that I don't follow or even want to hear from :(

Many thanks to all the awesome people involved in this work! @aicoboaie @helena_davies_ @MicaliNadia @JoellePasman @MischaLundberg @cbulik and many more without twitter (still not calling it X) 🙃.

In our previous paper we introduced our method to understand the genetic contribution to the risk of cardiometabolic diseases in individuals with a psychiatric diagnosis. Here we took a deep dive in eatings disorders specifically. nature.com/articles/s4146…

Check out our new work for @cedar_research! Using the register data of 17 million Danes and Swedes we were able to estimate the genetic correlation between multiple eating- and psychiatric disorders. We found new correlations with autism and OCD! medrxiv.org/content/10.110…

@LaramieDuncan Morteza is our star PhD student after all 😎

More accurate effect size estimates for CNVs - this is great!

@LaramieDuncan @doctorveera I think you'd like this!

Great paper again from the @LaramieDuncan lab!!

@asfkwong They'll never stop coming anymore. Next paper I add to a preprint server will be done with my spam emailaddress....

Wow! Just the 20 predatory journal emails so far since this went live last night, must be a great paper judging by all these lovely over the top compliments 😏

Our @CoMorMent study identifying genetic, immunometabolic, lifestyle, and psychosocial factors underlying the link between depression and cardiovascular disease in @NatureCVR, with @JoellePasman @oleaandreassen @UnnurAValdimars @mcintosh2001 @cathrynlewis nature.com/articles/s4416…

@Ella_Maru @NatureComms I glanced at your profile and I love your art work!

@JMeijsen @NatureComms Thanks for the response, Joeri. I appreciate the clarity on the study's scope. Great work!

I am happy to announce that our paper “Quantifying the relative importance of genetics and environment on the comorbidity between mental and cardiometabolic disorders using 17 million Scandinavians” is out in @NatureComms! nature.com/articles/s4146… 1/13

@Ella_Maru @NatureComms Thanks for reaching out! We didn't go that far. We really focussed on the register part and replicated the results using the genotype data.

@JMeijsen @NatureComms Great work, Joeri! Could the genetic variants in your study be linked to different inflammatory markers in individuals with both mental and cardiometabolic disorders?

@timrpeterson @doctorveera The 50-50 was just 1 example (adhd and t2d) many other combinations had very different G and E percentages :)

@doctorveera Genes and environment- 50/50% incredible study nevertheless. Huge effort that will hopefully pay dividends for a long time

Family-based heritability estimates of mental and cardiometabolic disorders based on genealogy and health records of 17 million (!) Scandinavians. Meijsen et al. Nat Comm nature.com/articles/s4146…

@SashaGusevPosts @unboxpolitics @NatureComms This looks good I'll read it, strange that I haven't seen it before...thanks!

@unboxpolitics @JMeijsen @NatureComms Zaitlen et al used genetically inferred kinship and kinship pairs, but not large-scale genealogies nor registry data nor genetic correlations. I think this current work is more analogous to Kaplanis et al (science.org/doi/10.1126/sc…). They're all good studies!

@GitaPathakPhD Seems a bit harsh don't you think? Given that for most institutions, you are still considered, as a postdoc, to be a trainee...

Am I misremembering or was the registration fee for postdocs at the #WCPG always the same as for PhD students and trainees and never conditional on how long you are a postdoc? 🫤 Because if you are a postdoc for >2 years you pay full price ($800 for group A countries) #WCPG2023

@mgeorgakis1 Please reach out if you want to know more about our paper! :)

🧬Heritability estimates for cardiometabolic diseases from nation-wide health records and genealogies of Denmark🇩🇰 and Sweden🇸🇪(🧑‍🤝‍🧑N=17M): 👉CAD 36% 👉ischemic stroke 28% 👉PAD 31% 👉hypertension 38% 👉T2D 55% 👉AFib 38% 👉intracranial aneurysm 75% nature.com/articles/s4146…

@doctorveera Thanks for sharing this Veera, hope you liked it! For a longer explanation of our work, you can see the little thread I made on @JMeijsen :)

I will end with this, we have set up a streamlined approach to calculate these estimates in both Sweden and Denmark, but we are always keen on extending our work to other disorders, countries, ancestry groups, disorders, and populations. If you are interested, let’s talk! 13/13

We would not have been able to do this work if it wasn’t for our other Nordic collaborators of the @CoMorMent consortium such as @jacob_bergstedt and other friends @yorgos_a, @John_J_McGrath, @MicaliNadia and many others without Twitter 12/13