Jack Pluenneke

SGLT2 inhibition in Patients with Type 2 Diabetes and CKD Experiencing a Deterioration in Estimated Glomerular Filtration Rate to <20ml/min/1.73m2 In patients with type 2 diabetes and CKD whose eGFR fell <20ml/min/1.73m2, continuation of canagliflozin was associated with persistent benefit for kidney and cardiovascular outcomes with no additional safety concerns. These data support current guideline recommendations to continue SGLT2 inhibitors until dialysis or transplantation. #Cardiology #MedTwitter #CardioTwitter #HeartHealth #Healthcare @safchat @brendonneuen @mvaduganathan @DrMarthaGulati @hvanspall @JavedButler1 @AndrewJSauer @ShelleyZieroth onlinejcf.com/article/S1071-…

Among patients with atrial fibrillation at high risk for stroke and bleeding, left atrial appendage closure was not noninferior to medical therapy in reducing the risk of stroke, embolism, major bleeding, or death at 3 years. Full CLOSURE-AF trial results: nejm.org/doi/full/10.10… Editorial: Left Atrial Appendage Closure — Another Overused Method in Cardiology? nejm.org/doi/full/10.10…

The era of lipid apheresis is over in hyperlipoprotein(a)-emia. Thank you @SamiaMoraMD for very your thoughful editorial on our Lp(a)FRONTIERS APHERESIS trial! academic.oup.com/eurheartj/arti…

📢 A NEW Summary of the #ISHLTConsensusConference on Graft Dysfunction within the First 72 hours after #HeartTransplantation is now available. 📖💡🫀 This document is a 10-year update summarizing the growing understanding of primary graft dysfunction (#PGD). View the top 🔟 takeaways ⤵️

Interested in integrating artificial intelligence (AI) into pharmacy practice? The Student/Trainee Committee is excited to host a 1 hour professional development session called "Integration of AI into Pharmacy Practice." Access the link on the Communities Page!

The report from the KDIGO Controversies Conference on Kidney Disease and Heart Failure has been jointly published in @Kidney_Int and JACC: Heart Failure! Read the report: Kidney International: kdigo.co/HF-in-CKD-Conf… JACC Heart Failure: kdigo.co/HF-in-CKD-Conf… Co-chaired by Dr. Nisha Bansal and Dr. Carolyn Lam, the conference convened a global group of experts, including nephrologists, cardiologists, related specialists, and patients, to examine recent advances, ongoing challenges, and future strategies for improving care for people with kidney disease and heart failure. Visit the conference website to download the report and for related resources:  kdigo.org/conferences/co…

An evaluation of AF, LVEF<50%, HF, and cardiogenic shock on commercial mavacamten in ~1500 patient onlinejcf.com/article/S1071-…

Exciting time for #Group2PH. Our new review in @JACCJournals highlights the evolving pathophysiology of PH associated with left heart disease and discusses emerging therapeutic strategies. A field long defined by “no therapies” may finally be changing. @yreddyhf @mardigomberg @lamcardio @ShahzebKhanMD @MUSC_Cardiology jacc.org/doi/10.1016/j.…

In the phase 3 TETON-2 trial involving patients with idiopathic pulmonary fibrosis, inhaled treprostinil was associated with a smaller decline in forced vital capacity and a lower risk of clinical worsening than placebo over 52 weeks. Full trial results: nejm.org/doi/full/10.10…

In an international, randomized trial involving patients with acute venous thromboembolism, the risk of clinically relevant bleeding was significantly lower with apixaban than with rivaroxaban during the 3-month treatment period. Full COBRRA trial results: nejm.org/doi/full/10.10…

MAPLE showed in oHCM --> BB worsen pVO2 Here is a triple crossover trial in nHCM showing BB worsening pVO2 jacc.org/doi/10.1016/j.…

A common Q in acute HF is what dose of diuretic to start with. In this pilot RCT we tested a simpler strategy of just giving 1 gram of lasix over 24 hrs to everyone even if diuretic naive. We saw more urine, lower venous pressure and no drop in CO or gfr doi.org/10.1093/ejhf/x…

Varenicline and Ventricular Ectopy After Myocardial Infarction: A Randomized Phase 2 Study In this phase 2 trial, varenicline significantly reduced PVC burden and nonsustained VT incidence in post-MI patients without evidence of a proarrhythmic effects. #Cardiology #MedTwitter #CardioTwitter #HeartHealth #Healthcare @JACCJournals @ACCinTouch @CMichaelGibson @DrMarthaGulati @hvanspall @AndrewJSauer @Hragy @biljana_parapid jacc.org/doi/10.1016/j.…

In patients with suspected sepsis, procalcitonin adds little diagnostic value and is unlikely to change management. Full context and comment from Deputy Editor Aaron J. Calderon: https://nej.md/4cNtEVe #MedTwitter

In adults with type 1 diabetes and chronic kidney disease with albuminuria, the decrease in the urinary albumin-to-creatinine ratio was significantly greater with finerenone than with placebo. Full phase 3 FINE-ONE trial results: nejm.org/doi/full/10.10… Editorial: Finerenone for Diabetic Kidney Disease in Type 1 Diabetes — A Fine Answer? nejm.org/doi/full/10.10…

🔥Real time AI use to ⬆️ clinical trial screening efficiency & enrollment! Sim pub @#THT2026 by @tremartyn et al. 🫀 AI-powered chart review for ATTR-CM trial eligibility — 🤖 1,476 EMRs processed in just 6 days 🎯 96% accuracy vs physician review 📋 99% NPV — rejection almost always appropriate 👀 97% eligible patients missed by routine screening ⚕️ 60% not even connected to a HF doc!😱 🏾 37% Black patients identified vs 7% through standard recruitment ✅ Clinician-in-the-loop kept it safe + actionable AI finding patients we miss. The future of equitable trial enrollment?🙏🏽 @JCardFail onlinejcf.com/article/ #FunctionNotFailure @hfcollaboratory

Don’t stop SGLT2i when GFR falls below 20ml/min - continue until dialysis/transplantation New analysis from CREDENCE led by @safchat in @JCardFail onlinejcf.com/article/S1071-…

Sotatercept in Group 1 PH improves RV‑PA coupling & increases CO reserve during exercise. Higher Hb from decongestion improves O₂ delivery, & skeletal muscle O₂ uptake also rises, supporting better exercise performance. jacc.org/doi/10.1016/j.… #JACC #THT2026 #cvPAH @yreddyhf

Obicetrapib in HeFH. Our paper now published in Nature Medicine. Well done Steve Nicholls @JohnKastelein Another tool in our arsenal

Among patients with anterior myocardial infarction, adding low-dose rivaroxaban to dual antiplatelet therapy did not significantly reduce left ventricular thrombus formation at 1 month but increased minor bleeding. ja.ma/4cF3mo4