Jacob Witten

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Jacob Witten

Jacob Witten

@JacobWitten1

Postdoc at MIT, interested in computational biology and bioengineering and volleyball and basketball

Katılım Temmuz 2019
107 Takip Edilen133 Takipçiler
Jacob Witten
Jacob Witten@JacobWitten1·
@MattBruenig I don't know how strong this effect is though so it might be small. I'd be curious to see it quantified though! Like, a plot of marginal productivity at each number of hours worked/yr for different countries
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Jacob Witten
Jacob Witten@JacobWitten1·
@MattBruenig GDP/hour worked is a confounded metric of productivity since more valuable work is done first, so working less will raise GDP/hour even if underlying productivity curve is unchanged. Since US works more, = GDP/hour --> US more intrinsically productive
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Jacob Witten
Jacob Witten@JacobWitten1·
@Bonecondor Good point, deer are always giving themselves anti-PD-1 injections when they get sick and Hippocrates wrote about ancient Greek tinctures of tyrosine kinase inhibitor
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Chairman Birb Bernanke
Chairman Birb Bernanke@Bonecondor·
Here are some drugs you may have heard of that entered the mainstream without RCTs: Aspirin, Penicillin, Ketamine (for depression), Lithium (for bipolar) RCTs confirm and scale knowledge. The hypothesis almost always comes from elsewhere, like folk medicine or animal behavior.
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Jacob Witten
Jacob Witten@JacobWitten1·
@phl43 Clearly he's an AI doomer trying to both wreck the world economy and using up all stockpiles of weapons that could be used to protect Taiwan, thus leading to an invasion. The ensuing recession and destruction of fabs will buy humanity another 2 years to figure out alignment
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Philippe Lemoine
Philippe Lemoine@phl43·
The real 4D chess theory is that Trump, far from being a dupe of Israel, has been a crypto-environmentalist and undercover Chinese agent for decades, who set out to convince the world to electrify and help China solve its overcapacity problem by buying its clean energy tech.
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owl
owl@owl_posting·
jacob works at @blueprintbio and dramatically undersells how consequential they have been in pushing pathogen-agnostic defenses closer to the overton window. e.g.: if you're curious about far-UVC, they have published a 146 page report over it here: blueprintbiosecurity.org/u/2025/06/Blue…
Jacob Swett@JacobSwett

This nails something important: the main barriers to pathogen-agnostic defenses like far-UVC and glycol vapors are largely funding and execution shaped. If you're excited about making these technologies happen, we'd love to have you join us!

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Jacob Witten
Jacob Witten@JacobWitten1·
@MongoTheGeek @zeta_globin You'd have to get really unlucky and have a frameshifted product be a self-antigen, but yeah if if that happened there could theoretically be some kind of autoimmune issue
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zeta
zeta@zeta_globin·
weird question but does anyone know of any clinical trials on the covid mRNA vaccines where they also did a placebo vaccine of SCRAMBLE MRNA so just as much mRNA in addition to a no mRNA control
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Jacob Witten
Jacob Witten@JacobWitten1·
@zeta_globin Theoretically could be weird/bad if you accidentally translate and create immune response to random new epitopes, i think the cleaner control is same mRNA with a bunch of stop codons right after the ATG
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Jacob Witten
Jacob Witten@JacobWitten1·
@tszzl also if I recall correctly Journey to the West spends a surprising amount of time on passports
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Jacob Witten
Jacob Witten@JacobWitten1·
@tszzl Water Margin is funny for this, it goes into great detail trying to make you hate the Song dynasty bureaucracy so much that you root for the bandit outlaws who are constantly murdering children and eating people
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roon
roon@tszzl·
much of the nature of the world is explained by the nature of bureaucracy and yet - bureaucracy is rarely written about well beyond cliches. the great authors and people who worked in a large organization are generally disjoint. more common in east asian media
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Joey Politano 🏳️‍🌈
Joey Politano 🏳️‍🌈@JosephPolitano·
I do mourn how media literacy has gotten so bad that people want obituaries to go "Ali Khamenei believed America was the Great Satan (The Economist believes America is not the Great Satan) and ruled Iran by divine authority (The Economist believes theocratic rule is immoral)"
Saul Sadka@Saul_Sadka

The Economist, in its “fighting back the tears” obituary for Khamenei, salivates with true depravity over Trump’s future death in grisly, if ecstatic, terms: “...when Mr. Trump’s body was ashes, eaten by worms and ants.” It makes the Washington Post and its infamous “Austere Islamic Scholar” obituary for Abu Bakr al-Baghdadi seem very quaint indeed. But I read the whole thing so you don’t have to. The key takeaways: 1. The USA is the Great Satan—no scare quotes. 2. For readers who don’t know what “Israel” is, the Economist helpfully translates it in parentheses as “the little Satan.” 3. Khamenei, otherwise known as “God’s Dictator,” had “divine right on his side” and had “countless reasons to hate the West,” which is an America-led “phalanx of morally corrupt countries.” 4. Khamenei was a sainted and humble man, dragged to power against his will, selfless and “heroically flexible” and unassailable—a “humble cleric from Mashhad who inherited the earth.” 5. Honourable in life, but perfect in death: what could be sweeter than delicious martyrdom? What could be “more deserving of paradise-to-come than to drink the pure draught of a martyr’s end”?! 6. According to the Economist, “Freedom, human rights, dress codes for women” are “tiresome Western tropes.” Yes, really. 7. All his troubles were economic: he was tormented by the West and by foreign enemies. All the crimes he ordered—beatings, killings, and so on—were, naturally, merely “a response” to those Western crimes. 8. He “rules by divine authority,” and “his tongue could channel God.” 9. He was just a ”mild-mannered cleric” gazed benignly from billboards and was a great teacher of forgiveness”. We have now surely reached the apogee of the decay of the legacy media in the West. Surely it can't sink lower than this?

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Jacob Witten
Jacob Witten@JacobWitten1·
Every piece of DoW news (up to and including the new name!):
Jacob Witten tweet media
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Jacob Witten
Jacob Witten@JacobWitten1·
Shouldn't we wait 6 months to excise the dangerous supply chain risk before launching any deranged wars? What if we can't supply the deranged war
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Jacob Witten
Jacob Witten@JacobWitten1·
Also it's a really bad crime though
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Jacob Witten
Jacob Witten@JacobWitten1·
C'est pire qu'un crime, c'est une faute
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Jacob Witten
Jacob Witten@JacobWitten1·
@CartoonsHateHer Is that a reason to be a Democrat though given the biggest cause of homelessness for full-time workers is housing scarcity? Not clear Republicans would be better but single-party Dem control over cities clearly doesn't work for building housing
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Cartoons Hate Her!
Cartoons Hate Her!@CartoonsHateHer·
Absolutely. There are full-time Amazon workers *who are homeless.* It's an indictment on our society that it happens. The "problem" if you will, are people who are genuinely violent and untethered from reality. They need institutionalization--but most don't.
Sturgeon's Law@Sturgeons_Law

IMO it's not useful to discuss homeless people as a monolith. The majority want shelter, & most of those live in shelters now, even amidst often-bad conditions. Of those on the street, some reject shelters because of the conditions, & others refuse housing no matter what. In this

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Jacob Witten
Jacob Witten@JacobWitten1·
@moultano @david_shane Its a reasonable thing to wonder in any case! It's an error to think welfare of homeless people is the only thing that matters even at the expense of having a society, but also bad not to care at all
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Ryan Moulton
Ryan Moulton@moultano·
@david_shane The post I am replying to is framing it as being for his benefit.
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David Shane
David Shane@david_shane·
Fascinating that we're literally talking about a mentally insane homeless drug addict who occasionally sets himself on fire and uses the street as his toilet, and our main concern is supposed to be "but would he be happier in an institution?".
Ryan Moulton@moultano

@Chris_arnade Do people like this end up happier involuntarily committed? It's certainly safer for him, and more pleasant for us, but is he happier?

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Jacob Witten
Jacob Witten@JacobWitten1·
@nabeelqu That's nice about Carlsen but whatever else you might say about Soviet chess training methods they did in fact produce many top performing chess players!
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