Jennie Jacques

What’s ME, again? Blood 🩸 test results with @AcadOfNutriMed “Oxygen-starved at a cellular level.” Clinical. Unarguable. More here ↙️ instagram.com/reel/DTxPsQlgk…

Professor Chris Ponting on the 116 blood molecule differences his team found in people with #MECFS “This is not a psychological disease” people did not alter their blood molecules just to “spook the psychiatrists”. Clip from @hope4mefibroni 2026

This study provides a strong preclinical rationale to evaluate nasal anti-CD3 mAb therapy in clinical trials. So grateful to the amazing collaborators on this work 🙏🏼

We pushed the system harder and asked whether anti-CD3 mAb treatment could be administered much later, at 4 weeks post-infection. This treatment was remarkably effective in reducing CNS inflammation and was accompanied by an increase in Tregs in the brain.

First, we tested whether anti-CD3 mAb administered nasally starting at 1 week post-infection for 4 weeks. The treatment restored microglial and astrocyte densities and reduced inflammatory cytokines.

Neuroinflammatory damage is a hallmark of Long COVID. Nasal delivery of anti-CD3 mAb induces Treg and has shown therapeutic benefit in various autoimmune and CNS models of disease. In this study, we asked whether anti-CD3 mAb can reduce damage and restore neurogenesis.

Our new preprint by @peowenlu @SaefIzzy @weinerlabhms and colleagues shows that nasal anti-CD3 monoclonal antibody treatment can reduce neuroinflammation in a mouse model of Long COVID, even when administered at 4 weeks after infection 🧠 biorxiv.org/content/10.648…

In The Hospital In January this year I spent 3 weeks in the hospital for a serious infection and related conditions. My experience there was at once a surprise and a discouraging setback that added to my symptom burden. In this post I relate my experience and thoughts on what it means for all of us. Read the whole piece on my blog or watch the video above. 💙 whitneydafoe.com/mecfs/?post=in… #mecfs #chronicillness #pwME #LongCovid

We’re proud to have Dr. Steve Deeks, who has garnered decades of experience researching HIV diagnostics & treatments, leading PolyBio’s VIPER diagnostics program for Long Covid. Said Dr. Deeks, “Having witnessed how a single test can transform a complex disease like HIV, I am fully committed to doing my part to develop tests for Long COVID. Validated diagnostics will allow us to run smarter, more targeted trials - and ultimately deliver effective treatments to patients faster.”

@ishbelfrazer @microbeminded2 We funded this $1M ME/CFS project with the same team at UCSF running VIPER. Findings will be fed into our same pipeline to innovate diagnostics for ME/CFS: polybio.org/projects/expan…

Dr. Amy Proal on the Tick Bootcamp podcast last week: “If you’re a pathogen and you’re going to infect someone, and persist in their body, the blood is not a smart place to be... A lot of pathogens over time will hide in a person’s tissue… Where they’re somewhat able to evade immune recognition.”

Our son loved the outdoors – invisible illness means he now can't walk or talk bbc.in/4sxUCVW

A study has found the menopause is linked to changes in the brain similar to those seen in Alzheimer's. Researchers found a significant loss of grey matter in post-menopausal women that could help explain why there are almost twice as many cases of dementia in women as in men.

What’s ME, again? Blood 🩸 test results with @AcadOfNutriMed “Oxygen-starved at a cellular level.” Clinical. Unarguable. More here ↙️ instagram.com/reel/DTxPsQlgk…

Reposting this: Alem Matthees, whose heroic effort to liberate the raw PACE trial data was followed by a collapse in his health, has recently improved somewhat. He's e-mailing again! virology.ws/2026/01/02/tri…

We need more journalists like @GeorgeMonbiot @davidtuller1 to keep spreading the truth 🔥

Brain fog isn’t just forgetfulness. It’s lost words, slowed thinking, and mental exhaustion that can impact every part of daily life. Your story could help researchers see the patterns others miss. 🧠 Share your story on unhide® today. unhidenow.org #brainfog #brainfogresearch

ME/CFS immune cell lines show unusual fat buildup. One specific membrane fat, PC(O-38:4), is much lower and almost separates ME/CFS from controls. Many triglycerides, diglycerides, and fatty acids are higher. A lipid enzyme PTDSS1 is higher too. Paper by @DanMissailidis & Co

1) With both symptoms and genetic evidence pointing to the brain, should the ME/CFS community do a coordinated push for brain banks and autopsy studies? The ongoing post-mortem studies in the Netherlands and the UK will give us a glimpse of how feasible and useful this is.

Full study by Mughal et al. (2025) in Biofabrication (open access) here: doi.org/10.1088/1758-5…