Jeremy Rudy

@DrAdamBorecky @Josh__Hardman Yep. This is the problem space we’re working on now with Praxis: translating safety and quality into a scalable operating model, especially around workforce readiness, delegated monitoring, and implementation economics.

@JeremyRudy @Josh__Hardman Thank you Jeremy! I tried to take a tentative stab at the economic question (room-day, breakeven, P&L) which deserves more attention as we move past “does this work?” towards for the “can it scale?” question.

New essay: Spravato did $1.7B in revenue last year on mixed-to-modest efficacy data. Now psilocybin is asking clinics to deliver fewer sessions, longer monitoring, and more expensive staff. The clinical model may work at the level of the patient. The question is whether it works at the level of the room. open.substack.com/pub/darkmatter…

@anesmithbeck Excellent assembly here! Bookmarked and shared.

@Josh__Hardman Thinking about it. Just reached out to them to potentially sponsor.

Who is coming to ICPR?

@thedarshakrana @cyantist Ah, perhaps this is why I often annoy people in debates. I rarely like to land in a definite place.

I accidentally broke my brain reading about Nobel Prize winners last month. There's this thing called "Janusian thinking" that basically explains why some people's minds work like magic while the rest of us think in straight lines. Named after Janus, the Roman god with two faces pointing opposite directions. The psychologist who discovered it, Albert Rothenberg, was trying to figure out what made breakthrough thinkers different. He interviewed dozens of Nobel laureates, major artists, revolutionary scientists. What he found sounds impossible. These people can hold two different ideas in their mind at the same time. They can explore both without switching back and forth or forcing a quick comparison. They can consider “yes” and “no” to the same question simultaneously and stay clear-headed. Einstein too talked about this when he described his relativity breakthrough. He was imagining riding alongside a beam of light while also standing perfectly still. Both perspectives at once. Mozart said he could hear an entire symphony "all at once," every note, every contradiction, every resolution happening in a single moment of awareness. Your average person's mind works like a courtroom. Evidence comes in, you weigh it, you reach a verdict. Case closed. But Janusian minds work more like... I don't know, like a quantum computer that can process multiple realities simultaneously until something new emerges from the overlap. I've started noticing it in conversations. When someone can genuinely see both sides of something without needing to pick one, it drives people nuts. They want you to land somewhere definite. The ability to live in that tension space reads as wishy-washy or indecisive. Most creative advice tells you to "think outside the box." But Janusian thinking is weirder than that. It's being inside and outside the box at the same time. It's thinking the box exists and doesn't exist simultaneously. Which explains why truly creative people seem slightly unhinged. They think they're choosing between realities. But, they're inhabiting multiple realities at once, mining the contradictions for insights the rest of us never see. Sadly, most of us have trained ourselves out of this ability. We've learned that holding contradictions feels unstable, so we rush toward resolution. We've been taught that changing your mind means you were wrong before, so we defend positions instead of exploring them. But the people changing the world have kept that childlike ability to hold impossible thoughts without needing them to make sense immediately. We just need to live in the questions everyone else is too scared to ask.

@gjurvetson Let's not let those Aussies beat us to nationwide deployment of these healing medicines!

Fantastic article on Australia’s MDMA-assisted therapy program. Already ~200 patients have received treatment with no serious adverse events reported. Early signals also suggest MDMA therapy may have more durable effects than psilocybin. Fascinating to watch this real-world data emerge. I hope our FDA will soon approve this life saving therapy for the 13 million US citizens suffering with PTSD. Cc @DrMakaryFDA

@evanbuhler I’m bullish on your approach

@sentientist This is a strange sequel to the mini-series "Archangel"

Stalin's granddaughter Olga Peters who has renamed herself Cherese Evans is a Buddhist convert running an antique shop in Oregon

@C_Angermayer Love it. I also wrote about the connections I see between AI, psychedelics (& nuclear fission) here:

I’ve just published my thoughts on the future of AI and robotics, with a particular focus on #mentalhealth. In short, I believe that without #psychedelics, an AI-driven future may fail. It may fail not because the technology won’t be extraordinarily positive. In fact, I am deeply optimistic that a post-AGI and robotics-enabled society can be profoundly beneficial for humanity, but because of the risk that the transition goes terribly wrong. Without the psychological tools to adapt, we may struggle to successfully navigate the massive disruption and change ahead of us. Psychedelics - and, by extension, $ATAI - could play a critical role in unlocking a future defined by abundance, resilience, and human flourishing.

@pmarca @grok wasn’t Marcus Aurelius a visitor of the Eleusinian Mysteries where they drank a psychedelic brew, making Marc’s quoting Marcus in the context of his recent podcast critiquing founders who do psychedelics rather hilarious?

Marcus Aurelius, Meditations, X.16: “To stop talking about what the good man is like, and just be one.”

@tszzl @pmarca What’s even funnier is Marcus Aurelius was a regular visitor to the Elusinian Mysteries, drinking the Kykeon and experiencing altered states. In fact he was the only “lay person” brought into the inner sanctum.

@pmarca an entire book where the guy is introspecting

@janellison @metcoalition @alicegcallahan @nytimes @matthewbaszucki Go Jan go!

1/ Today, @alicegcallahan from the New York Times @nytimes published an article on ketogenic diets and serious mental illness. It feels fitting. (link below) It was exactly ten years ago today that our son @matthewbaszucki, at age 19, was involuntarily admitted to Stanford's psychiatric hospital for manic psychosis. After a diagnosis of Bipolar I and a five year battle with debilitating symptoms, he found @ChrisPalmerMD and started ketogenic and metabolic therapies. His symptoms have been in remission since early 2021, and today, he is still in ketosis and is thriving. I just had the pleasure of watching Matthew present his story on stage at @realCSF's #CoSci26 conference in Las Vegas. His health, vitality, confidence and insight brought me to tears. He also participated on a panel about his experience with other inspiring individuals @DrEricRodgers @robynrdobbins who appear in our upcoming film from @wideeyetv @jenisenhart @realDaveFeldman, The Cholesterol Code, which premiered last Saturday and received a well-deserved standing ovation. (link below) The Times article highlighted three of our family foundation @BaszuckiGroup's funded published studies (Stanford, The Ohio State University, and U. Edinburgh) and the stories of two individuals who, like our son, found hope in ketogenic therapy and who have generously shared their stories and strategies with @Metabolic_Mind's THINK+SMART program (links below). My fifth decade started as the hardest of my life and ended as the most rewarding. I am deeply grateful to the work of metabolic psychiatry pioneers @ChrisPalmerMD @GeorgiaEdeMD @SethiSheba74345 and others who made my son's healing possible, to the researchers around the world studying the connection between metabolic and mental health, and to our entire team at Baszucki Group and Metabolic Mind for their dedication to this cause. We're on the brink of a new era in the treatment of mental illness. Godspeed to the ongoing research, clinical adoption, and sharing of personal stories that could help tens of millions of people around the world.

@Josh__Hardman In all likelihood? Nobody edited.

Sir, this is a Wendy's. FDA didn't 'rescind' Fast Track for $CMPS (it has BTD). GM-2505 is a hallucinogen. Relmada's esmethadone shelved last year. Spravato not "an inhalant form of ketamine". MDMA rejected in Aug 24, not Jun 25. Who edited this? psychologytoday.com/gb/blog/shrink…

@Filtermag_org @JackGorsline Incredible things are happening in New Mexico. We’re doing all we can do support them.

In a groundbreaking move, New Mexico has confirmed funding "to ensure all who qualify would have access [to psilocybin treatment], not just those with financial resources." Securing the $630k "was neither guaranteed nor simple," reports @JackGorsline: filtermag.org/new-mexico-fun…

@C_Angermayer @hubermanlab @pmarca @davidsenra Contrary to Marc's concern, it was my experience with psychedelics that unlocked me STARTING the founder journey. And yes, with all the grind it entails, it's a helpful reset 1-2x a year. We're ensuring these medicines are deployed safely & sustainably praxis.sabba.com

Also, once a founder starts a company, stress levels can become extreme. Psychedelics can be a powerful tool to manage that. If someone truly loves what they’re building, I see zero risk of them walking away. If anything, I believe regular psychedelic therapy makes you a better founder (and a better human overall). During COVID, my @ApeironInvests offered 100+ founders in our portfolio to cover medical psychedelic therapy (in the Netherlands, where it’s legal). More than 50 took us up on it. Many of them credit that experience with helping them get through one of the most intense periods imaginable for founders, and keeping both themselves and their companies intact.

After listening to @pmarca’s take about the risks of founders taking psychedelics on the new @davidsenra podcast, it is official, we are now in the Dawn of the Age of AI-quarius.

@DStrachman I dropped out of college and then ironically spent 15 years helping launch online degrees across 3 companies (most recently Coursera). Applied to 1517 last week, waiting to hear back!

We love working with creative and wily dropouts and renegade scientists before anyone else will cut a check and then watching the masses catch up over time. Be the first check, not the last!

@devonzuegel @kellywearstler Ha, my toddler has wobbled around right there. It's a great hotel in LA.

"When we design something, we don't look at anything in that category Designing a chair? Look at architecture. Designing a drinking glass? Look at earrings. That's how you create something new, by discovering inspiration in an odd place." —@KellyWearstler

@travisk @Deepneuron A glimpse at the inevitable future

Atoms. atoms.co/vision

@Liv_Boeree @SarahTheHaider Good, I'm ready for harm-free bacon.

@JeremyRudy @SarahTheHaider I believe so

Quitting pork was the easiest “personal sacrifice” I ever made in my life

@jomo137 They're doing great things in that state

Update from New Mexico!