Jude

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Jude

Jude

@Juli_Bla

Emerging Technologies and SynBio | @TwistBioscience | Functional genomics aficionado | If you can sequence it, you can crispr it.

Amsterdam, The Netherlands Katılım Kasım 2010
876 Takip Edilen636 Takipçiler
Jude
Jude@Juli_Bla·
@levelsio I had the same problem - now I use the Duux Whisper Flex2 infront of the bed pointing to the ajar bedroom door like 3-4 meter away. The Bernoulli effect drags the bottom concentrated CO2 out of the bedroom. Fan is super silent. I get close to 400ppm including a baby in the room
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@levelsio
@levelsio@levelsio·
I still haven't solved the CO2 bedroom challenge You open the window and you wake up from a 6am garbage truck or barking dogs and sunlight You close it, you suffocate in 1200 ppl at 5am I guess you really need some mini tube in your wall with a vent that opens and closed based on internal CO2 but how do I build that?
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Matt Durrant
Matt Durrant@mgdurrant·
Feel free to throw your hardest structural biology problems at Opus 4.7, and please share feedback so we can keep improving!
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Ignacio Rubio Somoza
Ignacio Rubio Somoza@I_Rubio_Somoza·
We synthesize a gene sequence and when we try to amplify the original plasmid in Top10, DH5 alpha or DH10 beta we always end up with a transposon insertion in the miniprep, any tips on how to avoid it?, thanks a lot in advance!
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World of Statistics
World of Statistics@stats_feed·
What did people love 1000 years ago, still love today, and will definitely love 1000 years from now?
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Jude
Jude@Juli_Bla·
@SynBio1 Could be just really reproducible pipetting skills
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Jude
Jude@Juli_Bla·
@ladanuzhna There is something much bigger coming: cas12, cas9, gene within gene
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lada
lada@ladanuzhna·
Biology woke up and chose violence
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Twist Bioscience
Twist Bioscience@TwistBioscience·
AI-designed proteins are advancing fast, but how do they perform in real biological systems? Bits to Binders found out…
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Jude
Jude@Juli_Bla·
@SynBio1 @the_yaniv At least after peer review and 13 months stuff in papers is 100% reproducible
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Jake Wintermute 🧬/acc
Jake Wintermute 🧬/acc@SynBio1·
It took Nature 13 months to publish Evo 2! 13 months! For reference: Opus 4.5 ended software engineering as we know it 4 months ago. ClawdBot added 2 million users in a single week in January. Academic publishing is so cooked it's not even funny nature.com/articles/s4158…
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Twist Bioscience
Twist Bioscience@TwistBioscience·
Lab-in-the-Loop! Now on demand, watch Vladimir Gligorijevic, PhD, Senior Director of AI/ML at Genentech, present a webinar on Lab-in-the-Loop, a new approach that integrates AI-driven design with targeted lab testing. Smarter AI-Driven Antibody Design: technologynetworks.com/biopharma/webi…
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Jude
Jude@Juli_Bla·
@jrkelly @npokorzynski It is the year 2034, after a one week power outage caused by a solar flare, FlAiming awakens to continue the 500x1920 well experiment. Strangely a white fluffy substance grew blocking bacterial growth…. And that kids is how we discovered antibAiotics.
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Jason Kelly
Jason Kelly@jrkelly·
@npokorzynski Lab work should stay!! Just not being done by hand. Tell the robots what experiments you want
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Thomas Norman
Thomas Norman@thenormanlab·
@Juli_Bla Thanks! Yes we think the cloning has a lot of uses outside of combinatorial CRISPR screens...
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Thomas Norman
Thomas Norman@thenormanlab·
New preprint on technologies to scale up CRISPR screens. We use them to map 665,856 pairwise genetic perturbations and outline a path to comprehensive interaction mapping in human cells. We also introduce an approach for cloning lentiviral libraries with billions of elements.
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Jude
Jude@Juli_Bla·
@iskander 😂 why work with all cell lines separately when you can pool. To be fair, I never had such summer students. Problem is what to do in winter and spring.
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alex rubinsteyn
alex rubinsteyn@iskander·
@Juli_Bla At the end of the summer: "here are your cultures sir, labels were unfortunately in erasable marker but they're probably all HeLa + mycoplasma at this point, I'll send you my draft recommendation letter"
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alex rubinsteyn
alex rubinsteyn@iskander·
What’s the simplest dumbest way to automate mammalian cell culture? Like, forget even experimental conditions / read-outs, is there an automated incubator with eg media changes?
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Ron Alfa
Ron Alfa@Ronalfa·
People keep asking. A big value driver in our Foundation Model deal is we 100% own the PRETRAINING data. It’s not public, it’s NOT owned by a university, etc
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Twist Bioscience
Twist Bioscience@TwistBioscience·
It is not just ATGC anymore; it is ATGC, Os and 1s now. Check these out… @TwistBioscience
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Keşfet

@levelsio @mgdurrant @btnaughton @I_Rubio_Somoza @calhoujd @ATinyGreenCell @stats_feed @SynBio1