SP Unkillable

I'd rather be around peaceful people I don't always agree with than hostile people I'm not allowed to disagree with.

@TheJeffPutnam This is just the generic crap people say when they want to sound like tough guys, but they're really just broadcasting how miserable they are in their own lives.

The death penalty is not an effective deterrent. Monsters like this should be skinned alive with a box cutter and have their exposed muscle tissue covered in brake cleaner and then whipped with bike chains until they finally die. And this should be LIVE broadcasted to everyone on earth as it happens in the middle of a town square. That’s a deterrent. And justice? True justice cannot be exacted until it’s possible to do it to him twice.

@johnbind2 I had to laugh when they started pushing the "Trump is senile" line. Like is there anything they haven't obviously done and then accused the other guy of it?

democrats put a zombie in office that took fewer questions from the press than any modern president. then accuse the president that goes toe to toe with them for hours all the time of being a danger to the press. WTF?

@OleChr @209Trigga Damn I don't even remember that. I'm not even sure how far I ever got.

@209Trigga @KeystoneSP I remember I was never able to beat the spaceship level.

Time for a remake

@wil_da_beast630 Sounds very California

(1) Bro is far whiter than me. Most Black radicals are. (2) "History of Consciousness?"

@bigDsreturn @RandomWsLs Any drunk girl in a college town

@RandomWsLs Who the fuck does this?

Impulse control left the chat the second she spotted that Delice Panettone She ripped the box open like fresh kill and devoured it raw in the aisle Why do they behave like animals and proudly record it for everyone to see ?

@RandomWsLs @GarbageHuman24 This is insane. Those things are dry as hell.

@OwenGregorian This isn't new. We learned about it in my bioscience class.

Brain scans reveal a universal neural signature for addiction | Bianca Setionago, PsyPost People with substance use disorder—whether addicted to alcohol, cocaine, heroin, or nicotine—share a strikingly similar pattern of abnormal brain connections, particularly within the brain’s reward and self-control circuits, according to a new meta-analysis published in Translational Psychiatry. Substance use disorder (SUD) is marked by an ongoing struggle to control drug or alcohol use despite harmful consequences. Scientists have long suspected that this loss of control is tied to changes in the brain’s reward system—the network that helps us experience pleasure, form habits, and make decisions. However, past brain imaging studies have produced inconsistent results, largely due to studies varying in the specific substances used, stages of addiction (e.g., active use versus long-term withdrawal), and the specific brain regions being investigated. To address this gap, a research team led by Xiaonan Zhang of the First Hospital of Shanxi Medical University in China conducted a comprehensive meta-analysis, a statistical method that pools data from many prior studies to identify overarching trends. They focused specifically on studies that utilized resting-state functional MRI (rs-fMRI), a technique that measures how different brain regions communicate while a person is awake but not performing a specific task. The team ultimately included 53 whole-brain fMRI studies in their analysis, covering nine substances: alcohol, nicotine, cocaine, cannabis, heroin, ketamine, amphetamine, areca nut, and methamphetamine. Combined, these studies included 1,700 people diagnosed with SUD (average age 39 years; approximately 19% women) and 1,792 healthy control participants (average age 38 years; approximately 30% women). Zhang and colleagues mapped functional connectivity patterns based on five key “seed” regions within the reward circuit: the anterior cingulate cortex, the prefrontal cortex, the striatum, the thalamus, and the amygdala. The results revealed a consistent and specific set of connectivity abnormalities shared across all types of SUDs. Broadly, people with substance use disorder showed significant dysfunction in the cortical-striatal-thalamic-cortical (CSTC) circuit. This is a critical neural loop connecting the brain’s frontal regions (responsible for logic, control, and decision-making), the striatum (central to motivation and reward), and the thalamus (which relays sensory and motor signals throughout the brain). Within this circuit, certain connections were overactive (hyperconnected), while others were underactive (hypoconnected). For instance, the prefrontal cortex showed stronger-than-normal connections with regions involved in heightened attention and executive function, but significantly weaker connections with the inferior frontal gyrus, an area critical for suppressing impulses. Similarly, the striatum was overconnected with the superior frontal gyrus—suggesting an overactive response to drug-related cues—while being underconnected with the median cingulate gyrus, a region involved in emotional regulation and pain processing. Furthermore, the thalamus displayed reduced connections with several frontal and cingulate regions, which aligns with the cognitive difficulties and impaired impulse control often seen in addiction. The researchers also found evidence of a second disrupted circuit connecting the striatum to memory- and emotion-processing regions, including the hippocampus and amygdala. This points to a role for disrupted emotional memory and regulation in sustaining addictive behaviors. Notably, when the researchers analyzed psychological assessments, they found a direct behavioral link: the degree of disconnection between the striatum and the median cingulate gyrus was strongly and negatively correlated with impulsivity scores in patients. In other words, the weaker that specific neural connection was, the more impulsive the individual tended to be. “We present, for the first time, a specific pattern of network abnormalities in [substance use disorder] patients based on key nodes of the reward circuit, offering new insights into functional deficits within and between these networks,” the authors concluded. They noted that by mapping these specific broken circuits, the medical field gains a theoretical foundation for targeted interventions—such as deep brain stimulation or transcranial magnetic stimulation—designed to restore normal brain connectivity. The study does have important limitations. Because it relied on existing data, there were significant age and gender differences between the SUD and healthy control groups. Additionally, individuals with serious psychiatric conditions alongside their addiction were excluded from the original studies; thus, these findings may not fully apply to the many real-world patients who suffer from both addiction and a co-occurring mental illness. psypost.org/brain-scans-re…

@itsmetabby98 @Iwendtster @Cowboy_Canna @Q23HQMVP Yeah definitely not, especially since you called for backup 😄 Just turn yourself in, man.

@KeystoneSP @Iwendtster Nope, not projection @Cowboy_Canna @Q23HQMVP

Every single one of the evil POS in the Epstein files. Feet first, slowly.

@itsmetabby98 @Iwendtster There's the immediate projection we knew was coming.

@KeystoneSP @Iwendtster Oh, I’m not miserable. I just have zero tolerance for people that harm fucking children. Are you a pedo? Is that why you’re pissed off huh?

Once again, if you wish harm on anyone, it's not about them. It's about you being miserable with your own life.

@itsmetabby98 @Iwendtster People are always so eager to tell everyone how miserable they are

@Iwendtster I don’t know if this would be slow and painful enough I kinda want to see them slowly bleed to death while being tortured

@Iwendtster That will definitely throw people off the scent

@DefiantLs "The far right"

Liberal on TikTok: “I made a stupid video about the president, the far right found it and posted it on Twitter, and then got me fired from my job”

@MayorOfLA Oh boy

I ran for Mayor to break away from the City’s broken system that has left us with deteriorating streets and backlogs of repairs that piled up for years.

@MMAFighting Are we still doing these desperate soap opera clips?

Khamzat Chimaev does not care about Sean Strickland's threats before #UFC328: "The guy says he's going to shoot me. So, let's go. Do that. … [Security] is not for me. It's for his safety."

@MattWalshBlog Plus porn

According to this, 30 percent of 7 year olds have a smart phone. By 11, over 60 percent have one. This is total madness. If you’re giving a smart phone to your 7 year old, you’re a moron, an incompetent parent, and when your kid turns into a screen addled zombie with no personality or goals in life, it will be your fault completely, you absolute dumbass.

@datruth_01 Idk how to do it on purpose but everyone always tells me I am.

Men, do y’all know how to flirt… or do y’all just stare, like posts, and hope we figure it out?

It's weird when bros can't talk politics without broadcasting their homoerotic fantasies.

@BorrachinhaMMA Let's go bro 🤙

I’m going to get what’s mine, just wait, I’m on my way! #paulocosta #ufc #secretjuice