Sam Kleeman, MD PhD

Thrilled to announce I have matched into the Internal Medicine-Research Track Program at @WeillCornell! #Match2026 @TheNRMP 🎉

Arguably the most boring step in genomics is the first one: normalization. Settled science. Scale + log. Move on. Except that here's been a huge blind spot in the field. And it matters for AIxBio. A 🧵about what I think may be one of the most important papers I've written. 1/

Excited to present the first pre-print from our group, an investigation the human bone marrow microenvironments in patients with myelodysplastic syndromes (MDS) and normal age-matched subjects using Xenium genotype-informed spatial transcriptomics: biorxiv.org/content/10.648…

Autoantibodies cause autoimmune disease, shape infection outcomes, and alter cancer immunotherapy. But what role might they play in neuropsychiatric disease? In our new preprint, Katlyn Nemani and @JillianRJaycox take on this question in schizophrenia. 🧵 biorxiv.org/content/10.648…

@aaronmring @JillianRJaycox Congratulations, very nice!

Register today for the next @WCMEnglanderIPM #PrecisionMedicine Research Conference, featuring Drs. Sam Oscar Kleeman (@KleemanSam) from @CSHL and Vered Stearns (@VeredStearns) from Weill Cornell Medicine! #BreastCancer #Biomarkers

Immune surveillance can be a double-edged sword. ⚔️ In @Nature, Endeavor Awardee @JanowitzTobias shows that the same B cell response targeting NMDAR-expressing breast cancer tumors can mature into antibodies that trigger autoimmune disease. #Sec9" target="_blank" rel="nofollow noopener">nature.com/articles/s4158…

Delighted to share that my PhD research studying the connection between anti-cancer immunity and autoimmunity, supervised by @JanowitzTobias and @Lab_FURUKAWA @CSHL has been published in @Nature today.

Pleased to share our new collaborative work on the link between anti-cancer immunity and anti-NMDAR encephalitis. Clinical sample, mouse model, BCR seq, cryo-EM, electrophysiology, behavior, etc. @JanowitzTobias @KleemanSam and more. nature.com/articles/s4158…

We are pleased to share our paper connecting anti-cancer immunity to autoimmune mediated neuropsychiatric disease. @KleemanSam @Lab_FURUKAWA @miriamferrer95 @jpreall @Mayo_AING @CSHL @NorthwellHealth @TBBCF @SimonsFdn @TheMarkFdn @NIH @BarbMarte nature.com/articles/s4158…

Early-career researchers thrive at CSHL! From the Janowitz lab, Sam Kleeman (@KleemanSam) has been selected for the 2026 Emerging-Generation Award, and Alice Wang has received a Predoctoral Fellowship award. Read more here! cshl.edu/janowitz-lab-m…

Spatial transcriptomics is powerful—but fragile. Our new @NatureGenet paper shows that cell-segmentation errors are widespread and can obscure much of what we think we’re learning. nature.com/articles/s4158…

Honored to receive a 2026 Emerging-Generation (E-Gen) Award from @the_asci! I am incredibly grateful to my mentors Tobias Janowitz (@JanowitzTobias) and Hiro Furukawa (@Lab_FURUKAWA) for their support throughout my PhD @CSHL @CSHLsbs.

Our new paper in @TheLancetPsych NMDAR-antibody is very different from most forms of psychosis. - Rapid Onset - Complex, Polysymptomatic features - Often starts with mood - Dynamic over a short timescale - plus some more specific characteristics url-shortener.me/2XKW

Where do cancers start? In the liver, not all cells are the same. The liver is divided into 3 “zones,” and each specializes in different metabolic tasks. We show in @Science that where a mutation occurs in a liver lobule can determine a cell’s fate. science.org/doi/10.1126/sc… (1/9)

Proud to share @niseto’s (new PI @TheCrick) paper: As a postdoc (@CSHL/@HopkinsMedicine), he found #NETs in necrotic tumors—I shrugged. But he looked closer: NETs block tumor vessel perfusion, causing necrosis, hypoxia, EMT & #Metastasis. nature.com/articles/s4158… @JHU_BDP @Nature

@CKBrierley @NatureGenet @ArbachHratch Congratulations!!!!

🚨🚨Paper out! 🚨🚨 Delighted to share our work, now published in @NatureGenet 🧬! shorturl.at/94s5S We identified a targetable, chromothripsis-associated genetic event in blast phase (BP) MPN, a particularly poor prognostic subtype of acute leukaemia. 1/n 🧵👇

This is a really important paper - immunogenic tumour associated antigens seem to be more associated with aberrantly expressed extragenic RNA than the classical mutations nature.com/articles/s4301…

"Why do I no longer enjoy my favorite food and activities?" - an important question from our patients with cancer and cachexia! Cancer is a disease of the whole body, including the brain. @KepecsLab @Pignatelli_Lab @miriamferrer95 @CancerGrand @CSHL science.org/doi/10.1126/sc…