Anguraj Sadanandam

Congrats to @cives_mauro, a recipient of a 2025 NETRF Investigator Award for his work with Co-Investigator @LabSadanandam, PhD to advance #immunotherapy for pancreatic #neuroendocrine tumors (#PanNETs)! Learn more ➡️ ow.ly/oWTS50YekyL @unibait @icrlondon

@AndreaSottoriva @EszterLakatos42 @LuisglsZ @gcresswell @cmaley @jansen_marnix @trevoragraham Congratulations!

How does the evolution of the cancer epigenome contribute to immune evasion? We investigated this in colorectal cancer, where we found that immune evasion follows a ‘Big Bang’ evolutionary pattern, initiated right at transformation: nature.com/articles/s4158…

Pediatric and Rare Cancers: @FilbinMariella, Rodrigo de Almeida Toledo, & Anguraj Sadanadam will address this topic in a session at the AACR-NCI-EORTC Conference on Molecular Targets and Cancer Therapeutics (Oct 22-26; Boston). brnw.ch/21wVIn8 #Targets25 @LabSadanandam

I am delighted to share that I have been elected as a Fellow of the Royal Society of Biology (FRSB). My thanks to colleagues, mentors, lab members, collaborators, and my family. #Biology #LifeSciences #RSB #FRSB @ICR_London

𝗜𝗖𝗚𝗔 𝗩𝗼𝗶𝗰𝗲𝘀 𝘛𝘩𝘦 𝘏𝘪𝘥𝘥𝘦𝘯 𝘊𝘳𝘪𝘴𝘪𝘴 𝘪𝘯 𝘕𝘰𝘳𝘵𝘩-𝘌𝘢𝘴𝘵 𝘐𝘯𝘥𝘪𝘢 𝗙𝗲𝗮𝘁𝘂𝗿𝗶𝗻𝗴: 𝗣𝗿𝗼𝗳. 𝗔.𝗖. 𝗞𝗮𝘁𝗮𝗸𝗶 Former Director, Dr. B. Borooah Cancer Institute 🎥 𝗜𝗻𝗱𝗶𝗮’𝘀 𝗖𝗮𝗻𝗰𝗲𝗿 𝗛𝗼𝘁𝘀𝗽𝗼𝘁 — 𝗕𝘂𝘁 𝗡𝗼 𝗢𝗻𝗲’𝘀 𝗪𝗮𝘁𝗰𝗵𝗶𝗻𝗴 “Cancer rates in Mizoram are nearly three times the national average — and still, we don’t fully understand why.” In this episode of #ICGAVoices, 𝗣𝗿𝗼𝗳. 𝗔.𝗖. 𝗞𝗮𝘁𝗮𝗸𝗶 spotlights a silent emergency unfolding in India’s North-East: 🔹 The region has the 𝗵𝗶𝗴𝗵𝗲𝘀𝘁 𝗰𝗮𝗻𝗰𝗲𝗿 𝗯𝘂𝗿𝗱𝗲𝗻 in the country 🔹 Unusual cancers — 𝗴𝗮𝗹𝗹𝗯𝗹𝗮𝗱𝗱𝗲𝗿, 𝗲𝘀𝗼𝗽𝗵𝗮𝗴𝗲𝗮𝗹, 𝗻𝗮𝘀𝗼𝗽𝗵𝗮𝗿𝘆𝗻𝗴𝗲𝗮𝗹 — dominate 🔹 But there’s a critical missing piece: 𝗴𝗲𝗻𝗼𝗺𝗶𝗰 𝗱𝗮𝘁𝗮 Without it, we are left treating symptoms — not causes. 🧬 𝗜𝗖𝗚𝗔 𝗶𝘀 𝘄𝗼𝗿𝗸𝗶𝗻𝗴 𝘁𝗼 𝗰𝗵𝗮𝗻𝗴𝗲 𝘁𝗵𝗮𝘁 — by building India’s first nationwide cancer genome map, designed to include underrepresented regions like the North-East. 📈 While ICGA’s data is currently under controlled access — 𝗶𝘁 𝗶𝘀 𝗯𝗲𝗶𝗻𝗴 𝗯𝘂𝗶𝗹𝘁 𝗳𝗼𝗿 𝗽𝘂𝗯𝗹𝗶𝗰 𝗴𝗼𝗼𝗱 𝗮𝗻𝗱 𝗼𝗽𝗲𝗻 𝗮𝗰𝗰𝗲𝘀𝘀, with equity and scientific transparency at its core. 💡 𝘐𝘧 𝘺𝘰𝘶 𝘢𝘳𝘦 𝘢 𝘤𝘭𝘪𝘯𝘪𝘤𝘪𝘢𝘯, 𝘳𝘦𝘴𝘦𝘢𝘳𝘤𝘩𝘦𝘳, 𝘰𝘳 𝘤𝘢𝘯𝘤𝘦𝘳 𝘤𝘦𝘯𝘵𝘦𝘳 𝘧𝘳𝘰𝘮 𝘵𝘩𝘦 𝘳𝘦𝘨𝘪𝘰𝘯 — 𝘸𝘦 𝘪𝘯𝘷𝘪𝘵𝘦 𝘺𝘰𝘶 𝘵𝘰 𝘫𝘰𝘪𝘯 𝘵𝘩𝘦 𝘮𝘪𝘴𝘴𝘪𝘰𝘯. 📌 Featuring: Prof. A.C. Kataki 🎬 Watch the reel: The Hidden Crisis in North-East India youtu.be/QU5MxG6-ooU #ICGAVoices Playlist: youtube.com/playlist?list=… 🔗 icga.in | Join us at hashtag#ICGA2025 @BorooahDr @ICMRDELHI @IndiaDST @DBTIndia @DrJitendraSingh @karandi65 @anandesh @KoppikerCb @StopCancerDoc @shekhar_mande @LabSadanandam @arvindkmurthy @deb030903 @AnuragAgrawalMD @suveeradhup #ICGAVoices #CancerInIndia #HealthEquity #CancerGenomics #NorthEastIndia #ICGA2025 #DataForGood #OpenAccessByDesign

#ICGAVoices 🎥 Rare Subtypes. Big Opportunity “A patient in Tamil Nadu might have a completely different subtype than one in Punjab — yet we treat them the same.” India’s vast genetic diversity holds clues to rare cancer subtypes that global datasets often overlook. In this #ICGAVoices reel, Prof. Anguraj Sadanandam @LabSadanandam explains why this diversity is not a challenge — it is a chance to innovate. 🔬 New subtypes. Better classifications. Localized trials. With the right data, India can lead in designing treatments tailored to its population. ICGA is building that data — a national resource to power discovery, diagnostics, and equity in cancer care. 📌 Featuring: Prof. Anguraj Sadanandam 🎬 Watch the reel: youtube.com/watch?v=twKYAK… -“Rare Subtypes. Big Opportunity” #ICGAVoices: youtube.com/playlist?list=… 🔗icga.in | Join us at #ICGA2025 @ICR_London | @wellcometrust | @gatesfoundation | @BIRAC_2012 | @DBTIndia | @IndiaDST | @ICMRDELHI | @ANRFIndia @DrJitendraSingh | @rajesh_gokhale | @karandi65 | @shivkuma_k | @anandesh | @StopCancerDoc | @KoppikerCb | @shekhar_mande | @stellensatz | @suveeradhup #CancerSubtypes #ICGAVoices #CancerGenomics #PrecisionMedicine #DrugDiscoveryIndia #GenomicDiversity #DataDrivenCare #ICGA

📢Just published!!! ◇Molecular Oncology Reporting Guidelines from ISMPO for India Thank you all for this amazing joint initiative💯 doi.org/10.1055/s-0045… #NGS #oncology #molecularoncology #pathology #precisionmedicine #clinicaltrials #targeteddrug

Original Article: Perioperative Chemotherapy or Preoperative Chemoradiotherapy in Esophageal Cancer (ESOPEC trial) nej.md/4apWlo5 Editorial: Multimodal Treatment in Locally Advanced Esophageal Adenocarcinoma — Two Interventions Better Than Three? nej.md/40rpHhl #Oncology

"Fall in love with your life. Wake up early, buy your favorite coffee, go for walks, eat good food, wear what makes you feel confident, and listen to your favorite music. Purposefully create these small moments that make you fall in love with your life." ~Unknown

Cheers to new beginnings! Let’s make 2025 a year of growth, resilience, and shared success. Embrace the challenges, celebrate the wins, and keep moving forward. Wishing everyone a prosperous and fulfilling New Year! 🎉✨ #HappyNewYear2025 #PancreaticCancer #colorectalcancer

I'm thrilled to announce that @ChanthirikaRagulan has successfully passed her PhD viva from my lab @ICR_London! Please join me in congratulating her on this fantastic achievement!

Sad news for all current graduate students out there. ChatGPT pretrained on scientific papers of the last two decades can now predict the results of your study. Oops. nature.com/articles/s4156…

With support from @PancreaticCanUK, a  team of ICR researchers led by Professor Sadanandam (@LabSadanandam) are exploring new methods to match each patient's specific cancer and genetic profile, harnessing the body's immune system and unique cancer markers called neoantigens.

We’re delighted to announce that we’ve funded five innovative new #PancreaticCancer research awards which all aim to take us a step closer to being able to detect early, treat better and save more lives.

ecDNA are rogue genetic material that amplify genes, contribute to treatment resistance and drive genomic heterogeneity. We report on the Origins and impact of extrachromosomal DNA today in @Nature nature.com/articles/s4158…

John Neoptolemos gave a great talk on the role of good clinical trials in #PancreaticCancer, beginning with the example of tuberculosis where Bradford Hill showed the importance of a randomized controlled trial. Also a shoutout to the immortal words of Karl Popper on scientific theory (refutable, falsifiable, testable). @ChampalimaudF

Incredibly honored to see our work on #uridine metabolism featured in the Cancer Metabolism 2.0 collection @SpringerNature , next to work from @LyssiotisLab and @LabSadanandam ! @owensskinner19 @joanblanco14 @VamsiMootha nature.com/collections/dj…

Media Partner:@Biopatrika Outreach Partner:@ClusterPune @anandesh @ravimehro @KoppikerCb @LabSadanandam @bushraiitk @shekhar_mande @aneeshkag @baral_tweets @Banya_Kar @suveeradhup @ShekharGrover84 #AasthaAggarwal #AnkitaSingh @akshaychit #NarendraKumar @UjjainiDasgupt2

Press Release: @NewsX by Lavanya R. : newsx.com/national/india… @anandesh @ravimehro @KoppikerCb @LabSadanandam @bushraiitk @shekhar_mande @aneeshkag @baral_tweets @Banya_Kar @suveeradhup @ShekharGrover84 #AasthaAggarwal #AnkitaSingh @akshaychit #NarendraKumar @UjjainiDasgupt2

@bushraiitk Congratulations!

Grateful to National Academy of Medical Science (India) for recognizing our research efforts in the fight against cancer. A big shout-out to the present and former members of my group. Many thanks to my clinical collaborators for their continuous support and collaborative spirit.