Furukawa Lab CSHL

We’re hiring! Our group at CSHL has openings for postdoctoral fellows in structural biology with a focus on ion channels and receptors in neurotransmission and cancer immunology. Join us for unique, cross-disciplinary science to boost your career. jobrxiv.org/job/cold-sprin…

biorxiv.org/content/10.648… New preprint from our lab! Solving antagonist-bound GPCR structures is becoming easier with fusion markers, but linker optimization between GPCR and marker is still a bottleneck. (1/2)

Happy to share our work on conventional and time-resolved cryo-EM studies of NTSR1, now published in Nature! nature.com/articles/s4158… Wonderful collab. w/ Sumino, Mitsutake, Kobilka, & Inoue labs. Congrats to @AlHSJCKtEfpFXtm, @kk_kawakami, Toshiki, Shun & everyone involved!

Join the HF_lab at CSHL for cutting-edge science and advancing your career. #cryo-EM #electrophysiology #neuroscience #cancer-immunology #antibody Postdoctoral Position in Membrane Protein Biology & Ion Channel Physiology @Lab_FURUKAWA Cold Spring Harbor Laboratory See the full job description on jobRxiv: jobrxiv.org/job/cold-sprin… #Antibody #cancerimmunotherapy #electrophysiology #neuropharmacology #structuralbiology #ScienceJobs jobrxiv.org/job/cold-sprin…

Auxiliary subunits reshape structural asymmetry and functional plasticity in heterotetrameric GluA1/A2 AMPA receptor core! Structures of the most abundant AMPA receptor di-heteromer in the brain GluA1/A2 in the closed, open, and desensitized states! nature.com/articles/s4146…

Antibodies Connect Cancer with Autoimmune Brain Disease The connection between cancer response and autoimmune disease in the brain lies with the antibodies deployed to fight cancer @KleemanSam @Lab_FURUKAWA @CSHL #autoimmunity #braindisease #antibodies hubs.li/Q048Dr280

Anticancer antibodies can evolve to cause autoimmune brain disease @Nature nature.com/articles/d4158… nature.com/articles/s4158… @JanowitzTobias @Lab_Furukawa @KleemanSam @cshl

Cool! Ectopic NMDAR expression in cancer unmasks germline-encoded autoimmunity nature.com/articles/s4158…

Delighted to share that my PhD research studying the connection between anti-cancer immunity and autoimmunity, supervised by @JanowitzTobias and @Lab_FURUKAWA @CSHL has been published in @Nature today.

Sometimes cancer seems to have a mind of its own. In #TripleNegativeBreastCancer, that could be a good thing! Read about the latest breakthrough from @JanowitzTobias, @KleemanSam, @Lab_FURUKAWA, and colleagues at @NorthwellHealth published today in @Nature. cshl.edu/immune-respons… #encephalitis #Inspiring Discovery #ScienceMakesLifeBetter  Image background: Felipe Serrano/Illustra SciLab

Pleased to share our new collaborative work on the link between anti-cancer immunity and anti-NMDAR encephalitis. Clinical sample, mouse model, BCR seq, cryo-EM, electrophysiology, behavior, etc. @JanowitzTobias @KleemanSam and more. nature.com/articles/s4158…

We are pleased to share our paper connecting anti-cancer immunity to autoimmune mediated neuropsychiatric disease. @KleemanSam @Lab_FURUKAWA @miriamferrer95 @jpreall @Mayo_AING @CSHL @NorthwellHealth @TBBCF @SimonsFdn @TheMarkFdn @NIH @BarbMarte nature.com/articles/s4158…

The HF Lab postdocs, Hyunook Kang and Ruben Steigerwald, are presenting their posters today at #BPS 1:45 pm~2:45 pm. LB35 (Hyunook) and LB37 (Ruben) Please drop by!!

Alzheimer’s & Dementia Education Week: @Newsday @T_Cusaac spotlights CSHL research—“Alzheimer’s disease discovery: Cold Spring Harbor research with key protein improves memory in mice with symptoms.” CSHL Prof. Nicholas Tonks and team found blocking PTP1B improved learning & memory in an Alzheimer’s mouse model. Link in bio. newsday.com/news/health/al… #Alzheimers #AlzheimersAwareness #InspiringCuriosity #ScienceMakesLifeBetter

Alzheimer’s is often talked about in numbers. But for families, it’s personal. “It’s a slow bereavement,” says CSHL Professor Nicholas Tonks, whose mother lived with Alzheimer’s. “You lose the person piece by piece.” While brain plaques are part of the problem, Tonks and his lab found that another naturally occurring protein, PTP1B, which he discovered back in 1988, drives memory loss, offering a promising new target for future therapies. Targeting PTP1B improved learning and memory — and helped the brain’s immune cells clear harmful plaques. Learn more about this discovery and the early, but hopeful step toward slowing progression and improving quality of life. cshl.edu/researchers-fi… 🔖 Save to return to this story 📥 Share to spread awareness 🧠 Follow for more breakthroughs shaping the future of medicine #Alzheimers #InspiringDiscovery #ScienceMakesLifeBetter

Conformational Remodeling Underlies Activity Loss in Disease-Linked Asparagine Synthetase Variant biorxiv.org/content/10.648… Delighted to share this collaborative work led by Dr. Wen Zhu’s lab, revealing the mechanistic basis of an ASNS disease-associated mutation.

Honored to receive a 2026 Emerging-Generation (E-Gen) Award from @the_asci! I am incredibly grateful to my mentors Tobias Janowitz (@JanowitzTobias) and Hiro Furukawa (@Lab_FURUKAWA) for their support throughout my PhD @CSHL @CSHLsbs.

We have postdoctoral positions available for patch-clampers and structural biologists #cryoEM #electrophysiology #cancerneuroimmunology #neuropharmacology jobrxiv.org/job/cold-sprin…

Our paper on conductance control and neurosteroid binding in NMDAR has been officially published. I have attached a movie that describes a sub-open and a full-open channel. Surprising diversity in neurosteroid binding patterns as well. nature.com/articles/s4158…

Hiro Furukawa @Lab_FURUKAWA @CSHL provides commentary on new work by Lotti et al. (hubs.la/Q03WGByG0) which reports a new #NMDAR subtype-selective allosteric inhibitor with improved potency and elucidate its mechanism of inhibition. hubs.la/Q03WGvcf0