Jacqueline Oliva

MHC-II-restricted neoantigen vaccine reverses immune microenvironment and overcomes resistance to immune-checkpoint inhibitors in cold tumors @MedCellPress #AAI2026 hubs.li/Q04c5wVs0

A new LC–MS/MS method captures key epigenetic metabolites (SCFAs, SAM, acetyl-CoA), advancing studies of metabolic control in #epigenetics. 🏛️@yaneslab @jmirobla @universitatURV 🔗sciencedirect.com/science/articl…

Online now: Memory T cell aging and rejuvenation dlvr.it/TRpM36

uPAR CAR T cells eradicate primary and metastatic solid tumors with minimal myelodepletion by targeting both tumor cells and the stroma in preclinical models @CellCellPress @LoweLabMSKCC @Columbia cell.com/cell/fulltext/…

Age-related NF-κB activation in fibroblasts remodels the lung resident immune system and promotes the emergence of pro-inflammatory Gzmk+ T cells @ImmunityCP @UCSF cell.com/immunity/fullt…

Cole et al. used HCW9206 – a soluble tissue factor fusion protein that links IL-7, IL-15/IL-15Rα superagonist, and IL-21 – for the generation of T stem cell memory (TSCM)-enriched polyfunctional CAR T cells, without requiring anti-CD3/CD28 activation. In a humanized mouse model of HIV infection, HCW9206-stimulated duoCAR T cells (simultaneously targeting two HIV epitopes) showed superior viremia suppression compared to duoCAR TαCD3/CD28 cells. CD19 CAR THCW9206 cells exhibited increased functional persistence and elimination of an initial and subsequent rechallenge with NALM-6 leukemia cells in vivo compared to CD19 CAR TαCD3/CD28 cells. bit.ly/4sHTkYv

Preprint: BMAL1 dependent and independent CLOCK functions that program naïve CD4⁺ T cell fate, restrain Th17 differentiation, and preserve immune homeostasis researchsquare.com/article/rs-910… @MayoClinic

For decades, we taught a simple rule: MHC I → CD8 T cells, MHC II → CD4 T cells. Turns out, that’s incomplete. MHC I doesn’t just help CD8s “see” cells — it also protects cells from CD4 T cell–driven killing.nature.com/articles/s4159…

#Throwback CORRESPONDENCE | @KatiHanhineva et al. Harmonizing human plasma metabolite annotation with Plasma Benchmark nature.com/articles/s4225…

Nature research paper: Exposed phosphatidylserine is an inhibitory molecule in T cell exhaustion go.nature.com/4dINEsy

Principles of lymph node organization reveal lymphoma-induced reprogramming of stroma-derived chemokine networks and loss of tissue organization in nodal B cell lymphoma @NatureCancer @AnnaMathioudak1 @DKFZ @JoppSaile @zauggj @haas_lab nature.com/articles/s4301…

nature.com/articles/s4158… rdcu.be/e928r @Chris_B_Medina work in @rafiahmed_lab is out. If you are interested in PS-mediated immune suppression this is worth checking out.

Repair condensates and lipid domains in lysosome integrity dlvr.it/TRjjL5

Exposed phosphatidylserine is an inhibitory molecule in T cell exhaustion @Nature @EmoryUniversity @rafiahmed_lab nature.com/articles/s4158…

nature.com/articles/s4158… memories of inflammation!

Hot Nature Paper ! Boosting CAR-T by proteosome inhibition. Exhausted T cells have depolarized mitochondria which causes increased proteosome activity. Increased proteosome activity causes regulatory heam which stimulates more T cell exhaustion. nature.com/articles/s4158…

New! Online now: Mitochondrial lactate venting limits oxidative stress dlvr.it/TRgqtQ

#SpatialTranscriptomics #CellSegmentation FastReseg github.com/Nanostring-Bio… Using transcript scoring +"spatial doublet" test to rectify segmentation errors🥸 vs transcript-dominant approaches: Baysor Proseg @brukerspatial @SciReports 2025 nature.com/articles/s4159…

Type I IFN drives #neutrophil swarming, impeding lung T cell–#macrophage interactions and #TB control. From William Branchett, Anne O’Garra et al. hubs.la/Q046WpkP0 📘 Updates on the Immune Responses to #Tuberculosis and #HIV: hubs.la/Q046Wr7Y0 #KSTB26 #KSHIVVax26

#Macrophages can restrict immune infiltration of #tumors by inhibiting the formation of collagen III-rich networks that permit T cell and neutrophil entry. @heleneDmoreau @LennonLab Learn more in Science #Immunology: scim.ag/4shqkGL