LuLin Jiang

Now online, the main paper from my postdoc! A huge thank you to my coauthors, the Adams lab, and Peter @AdamsBioAging nature.com/articles/s4146…

APEX peroxidase is a versatile tool for proximity labeling and electron microscopy (EM) but its requirement for toxic H2O2 is a liability. We now report LaccID, a multicopper oxidase evolved from an ancestral fungal laccase that oxidizes aromatic substrates using non-toxic O2 instead of H2O2. We use LaccID for EM imaging of cultured cells and fly brains, and for proteomic mapping of the changing surface composition of T cells that engage with tumor cells via antigen-specific T cell receptors.

ISMND's Publication & Science Programs Officer and @MolNeuro Senior Editor Dr. Hongmei Li is at the ISMND booth (#1848) at #SfN2024 as part of our 'Meet the Editor' sessions! Catch her from 2pm-3pm today 🤓

Wonderful collaboration with @MichaelvdWeijer and the Carvalho group! We identify a new substrate, Tapasin, for RNF185-Membralin ERAD complex and a novel role of the complex in regulating the antigen presentation 🎉🎉🎉

A new study by Nirmalya Dasgupta in the lab 10.1016/j.molcel.2024.08.006 Nirmalya shows that histone chaperone HIRA and PML collaborate to control the SASP of senescent cells via cGAS/STING. Great work and congratulations, Nirmalya! sbpdiscovery.org/press/the-secr…

We are excited to announce Dr. Aaron D. Gitler @Stanford as our next ISMND Science Webinar speaker! Title: Expanding mechanisms and therapeutic targets for neurodegenerative disease August 15, 2024 1pm-2pm (ET) Host: Philip Wong, Ph.D. Register: bit.ly/4fpzfjD

Registration closes August 12 for this great meeting!

New study led by talented post doc in the lab @Aaron_Havas : 1) aged tissues at increased risk of cancer due to "precarious balance"; 2) age-activated IFN signaling is an adaptive response to prevent cancer in older tissues, but w/ maladaptive consequence. tinyurl.com/2k4nzs49

@kumsta @Nia Congratulations 🎉🎊🍾!!!

The Kumsta Lab is now funded by the @NIA! It was a long road to get here with the first submission in Oct 2020, then July 2021, then Oct 2022 and finally Nov 2023!!! I kept on working on it, strengthened the preliminary data, simplified the writing and got lucky in the end!

Microglial-derived C1q integrates into neuronal ribonucleoprotein complexes and impacts protein homeostasis in the aging brain. @CellCellPress cell.com/cell/fulltext/…

Very insightful study! What are the non-genetic non-environmental causes of variation in lifespan? This is well-documented in genetically identical worms living in identical environment (same dish). The don’t all die at the same time. Why not? cell.com/cell/abstract/…

T cell-mediated microglial activation triggers myelin pathology in a mouse model of amyloidosis @NatureNeuro nature.com/articles/s4159…

Super excited to announce our latest work in @MolNeuro! We generated new anti-acetylated-tau-K174 antibodies that effectively mitigate neurobehavioral impairments and reduce pathology in PS19 mice— alone and in conjunction with TBI. (1/5) Details here: bit.ly/4bbKokA

After focal CNS injury, local mature #astrocytes dedifferentiate, proliferate and become transcriptionally reprogrammed; these wound repair astrocytes are the predominant source of neuroprotective borders that re-establish CNS integrity around lesions nature.com/articles/s4159…

I am honoured to coauthor one of my favourite papers of all times when it comes to #mitochondria #ageing and #senescence! cell.com/developmental-… So things are not always as we dogmatically assume. Mitochondrial and "-phagy" dysfunctions are reported to occur with ageing...

Happy to share our new publication: Fate-mapping and functional dissection reveal perilous influence of type I interferon signaling in mouse brain aging | Molecular Neurodegeneration | Full Text …arneurodegeneration.biomedcentral.com/articles/10.11…

Neurodegeneration and demyelination in multiple sclerosis: @NeuroCellPress cell.com/neuron/fulltex…

💫NEW: Feng & co show that the major nucleoid protein TFAM interacts with cytoplasmic LC3B during oxidative or inflammatory stress to attenuate #mitochondria DNA-induced #inflammation via the #cGASSTING pathway. 👉rdcu.be/dKH7Z nature.com/articles/s4155…

STING orchestrates the neuronal inflammatory stress response in multiple sclerosis: @cell cell.com/cell/fulltext/…

Astrocytes remember...from @QuintanaLabHMS @KeystoneSymp #KSNeuroImmune24 discussing his @Nature paper nature.com/articles/s4158…. Read the @ImmunityCP Spotlight of his work here "Astrocytes remember inflammation" authors.elsevier.com/a/1j5C93qNrUxt…