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In vitro and in vivo derived macrophages occupy distinct phenotypic states biorxiv.org/content/10.110… #biorxiv_immuno

RESEARCH | AD Rao, L Cai, RJ DeBerardinis, @JenniferGillMD et al (@UTSWMedCenter) A detailed metabolic comparison between primary #tumours from #patients and their matching #xenografts, which identifies conserved as well as divergent #MetabolicPatterns nature.com/articles/s4225…

An age-related decrease in leptin contributes to CD8+ T cell aging in the tumor microenvironment @CellRepMed cell.com/cell-reports-m… 🇨🇳

My lab @MBIsg and @NUSMedicine is recruiting a fully-funded postdoc to start in Jan 2026! Interested in cell and tissue mechanics, transcriptional regulation of tissue health, or AI/ML for disease mechanobiology? Come join us in Singapore! mechano-medicine-lab.com/positions

🚨 REVIEW 🚨 #Ageing alters immune function and cancer outcomes. McAllister et al. explore how age-resolved immunoprofiling and models of ageing haematopoiesis reveal immune dynamics and new paths to optimize cancer therapy across age groups. bit.ly/41R6Qxt

The goal of a PhD is not to learn some facts or read a few papers or learn a bunch of techniques. The goal of a PhD is to learn independence, problem solving, how to finish things you start, resilience, & gain the ability to adapt & think creatively. Learning these things is hard

NEW content online! Ageing, immune fitness and cancer bit.ly/3JdVu0c

NEW content online! Stromal senescence contributes to age-related increases in cancer bit.ly/40NxWFw

Part Three of a series of investigations from my lab (ttelab.com) looking at how we can recapitulate cancer-associated fibroblast (CAF) heterogeneity in vitro, is now out in Advanced Healthcare Materials! 👉 lnkd.in/g2nKGvWH

Temporal dynamics of CLDN18.2 expression following zolbetuximab treatment in advanced gastric cancer - ESMO Gastrointestinal Oncology esmogastro.org/article/S2949-…

Online Now: Macropinocytosis maintains CAF subtype identity under metabolic stress in pancreatic cancer dlvr.it/TM5hVJ

💡 Scientists at @unil found that glutamine synthesis by CAFs promotes the polarization of pro-tumorigenic TAMs and supports tumor growth by altering TAM composition, highlighting the pivotal role of CAFs in shaping the immunosuppressive TME. @JExpMed | bit.ly/4lFVTXt

Everyone working in a STEM field should read this - ‘writing is thinking’ nature.com/articles/s4422…

Foam cells are dysfunctional, lipid-laden macrophages. Data indicate that the events underlying foam cell formation are disease- and microenvironment-specific, opening new avenues for disease-specific biomedical research. Learn more: ow.ly/Ah0k50WlLiQ.

Cisplatin and temozolomide combinatorial treatment triggers hypermutability and immune surveillance in experimental cancer models dlvr.it/TM0Npb

I’m happy to share our latest work on tumour necrosis! During my time in the @megeblad lab, we found that tumour necrosis is not a passive phenomenon secondary to tumour growth, but an active phenomenon driven by neutrophils and NETs! Thread below: (1/13) nature.com/articles/s4158…

Enjoy! 🧩 openbookpublishers.com/books/10.11647…

Lars Kemp (@kemp_lars) and a team in the @GloerichLab analyzed gastric tumors to identify the molecular changes that contribute to the progression of indolent to aggressive diffuse-type #GastricCancer legions. 🔖 @Gut_BMJ: bit.ly/44SiD0r

"No one’s Ph.D. journey is the same, and no one deserves to be shamed for how long it takes." #ScienceMagArchives scim.ag/3PjwJzf