Maria Elena Melica

Our new study is out! By STED microscopy on kidney biopsy and ELISA assays we show 1/3 of pediatric and half of adult patients (more in primary FSGS) have autoantibodies against slit antigens different from nephrin. i.e. anti-slit Abs kidney-international.org/action/showPdf…

Look how much more important is to know if a patient is genetic or has anti-slit antibodies than if has MCD or FSGS at kidney biopsy. We have finally come to the era of autoimmune, genetic and adaptive podocytopathies. No more MCD or FSGS used as diagnosis!

Now online in @NDTsocial Global epidemiology of kidney cancer @FrancescaBeche @cirluigi academic.oup.com/ndt/advance-ar…

Excited to share our new work: Simulated microgravity to investigate glomerular mechanobiology 👇👇 One small step towards #kidney progenitor in #Space🌌🚀 stemcellres.biomedcentral.com/articles/10.11…

We just published detailed protocols for preparation of human kidney progenitor cultures and their differentiation into podocytes, a very useful tool for study their biology bio-protocol.org/e4757

I'm excited to share my work in constructing single-cell atlas of glomerular parietal epithelial cells.

8/ Melica, @PRomagnani and colleagues found that parietal epithelial cells (PECs) are renal progenitor cells with similarities to the bone marrow stem cell niche. science.org/doi/10.1126/sc…

@rita_s_almeida @IOPscience @InterlynkH @COMPASS_RG @joaofmano Congrats Rita!

Happy to share our newest review paper on #Biomaterials of human source for #3Dprinting strategies 🧪⚡️ Check it out! 👀➡️ doi.org/10.1088/2515-7… via @IOPscience Work performed under the scope of a @InterlynkH #H2020 master thesis! 👨🏽‍🎓Well done! @COMPASS_RG @joaofmano

Proud and humbled to share our recent paper on @NatureComms!It's such a thrill to see the paper finally out! Huge thanks to my PI @PRomagnani and to @ElenaLazzeri2 How does the kidney adapt to AKI? #polyploidy #AKI #CKD 👇 nature.com/articles/s4146…

This review demonstrates that many signaling pathways such as Wnt-Ctnnb1, Hippo, Pi3K-Akt, Rb-E2f or p53-Mdm2 are involved in the regulation of cell cycle re-entry and progression in adult mammalian cardiomyocytes. doi.org/10.1042/CS2021…

This week's new issue of Science Translational Medicine has arrived! fcld.ly/v0fdjvb

And also many thanks to our amazing collaborators and mentors from LMU Munich @hjanders_hans and @StefanieSteige6

What a journey @MarEleMelica!!! This project was a life-changing experience. Congrats to you and to our fantastic team, we are all so incredibly proud 💪

Many thanks to my amazing and hard-working colleagues! @GiuAntonelli12 @RobeSemeraro @AngelottiLucia @giammylugli @samuela_land @ RavagliaF @gildalaregina @CarolinaConte5 @letiziadechiara @AnnaPeired @BeneMazzinghi @alice_molli @RagliantiV @GuzziFrancesco @ElenaLazzeri2

Thrilled to share our recent work. Differentiation of crescent-forming kidney progenitor cells into podocytes attenuates severe glomerulonephritis in mice is now available on @ScienceTM, and it made the journal cover! Thanks to my mentors @PRomagnani and @LasagniLaura_1!

Turning crescents into podocytes: the podocyte marker synaptopodin in purple and the renal progenitors in green. Our new study the cover story of Sci Transl Med this week science.org/doi/10.1126/sc…

The crescent is a clonal lesion generated by expansion of a single progenitor cell reminding stem-cell mediated diseases of the bone marrow. Shown in our new study by lineage tracing of single renal progenitors science.org/doi/10.1126/sc…

What is a crescent? An abnormal response of renal progenitors while trying to replace lost podocytes. Our new study shows reversal of crescents into podocytes is anyway possible and changes disease outcome science.org/doi/10.1126/sc…

Congratulations to the top 30 Young Nephrologist Platform (YNP) abstracts in this year’s European Renal Association Congress!! 🤓🇪🇺 @ERAkidney @ynptweets @franzfontanello @MariaEl30357435