Matt Buckley

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Matt Buckley

Matt Buckley

@MatttBuckley

neuro, aging, therapeutics building... Past - Cofounder @RetroBio_; PhD @BrunetLab

Bay Area, California Katılım Temmuz 2019
997 Takip Edilen1.2K Takipçiler
Matt Buckley
Matt Buckley@MatttBuckley·
Unusual & powerful move by @CellularIntelHQ: One of the most advanced cell replacement assets will continue it's path to full approval and improving humanity in the hands of AI-centric biotech rather than big pharma @novonordisk. Congrats @MichaBreakstone and the Cellular Intelligence crew. Fire video too!
Micha Breakstone@MichaBreakstone

Today we’re sharing a defining moment for @CellularIntelHQ, for cell therapy, and hopefully one day for patients with Parkinson’s. We’re acquiring STEM-PD, a Phase 2-ready allogeneic cell therapy program for Parkinson’s from @novonordisk, who'll also be investing in CI.

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Matt Buckley
Matt Buckley@MatttBuckley·
so curious to see how, for example, GLP1 peptides, consumer-driven blood work, fitness culture, next-gen AD antibodies, embryo selection, & advanced replacement therapies all combine to extend this plot and continue to defy the pink-dashed predictions of human stasis
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Joshua Kushner
Joshua Kushner@JoshuaKushner·
C.S. Lewis: The Inner Ring
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Matt Buckley
Matt Buckley@MatttBuckley·
Artemis II, Dark Side of the Moon
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Matt Buckley
Matt Buckley@MatttBuckley·
Unique and hard won vertebrate aging dataset and analysis aging by duo @clairebedbrook and @ravi_nath from my alma mater @BrunetLab. Less inflamed animals separated in behavior space early on and lived much longer.
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Claire Bedbrook@clairebedbrook

Aging may feel gradual… but what if it’s not? In our paper out today, we tracked fish continuously from puberty until death. This gave us a unique view of how aging unfolds across the adult lifespan. 🧵

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Marc Andreessen 🇺🇸
Marc Andreessen 🇺🇸@pmarca·
My information consumption is now 1/4 X, 1/4 podcast interviews of the smartest practitioners, 1/4 talking to the leading AI models, and 1/4 reading old books. The opportunity cost of anything else is far too high, and rising daily.
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Matt Buckley
Matt Buckley@MatttBuckley·
100 day supply of low dose statins, no insurance: $11.30 on Amazon. Sometimes the system works.
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🦆@ninetysevenjag·
@enbyslayer one must imagine Sisyphus chill asf
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Matt Buckley
Matt Buckley@MatttBuckley·
An interesting part of this not remarked on much was when elon struggled to defend SpaceX's mission to "extend consciousness to the stars." This hasn't happened in prior talks. He now fears that SpaceX might end up only extending (AI) intelligence to the stars. AI will be the vast majority of total intelligence, and the relationship to consciousness remains unclear. His humanism and truth-seeking drives are in painful tension now.
Dwarkesh Patel@dwarkesh_sp

.@collision and I interviewed @elonmusk. 0:00:00 - Orbital data centers 0:36:46 - Grok and alignment 0:59:56 - xAI’s business plan 1:17:21 - Optimus and humanoid manufacturing 1:30:22 - Does China win by default? 1:44:16 - Lessons from running SpaceX 2:20:08 - DOGE 2:38:28 - TeraFab

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Matt Buckley
Matt Buckley@MatttBuckley·
2-3) Lack of correlation to other industries AND lack of correlation WITHIN the industry itself
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Matt Buckley
Matt Buckley@MatttBuckley·
enjoyed this @verdadcap biotech whitepaper top 3 figures: 1) bio performance after periods of S&P-relative underperformance
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Elliot Hershberg
Elliot Hershberg@ElliotHershberg·
Welcome to the world, Rosalind Hershberg 🧬💜
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allen institute
allen institute@AllenInstitute·
Microglia feet are highly dynamic and can be in contact with dense networks of axons. In this video by our #ElectronMicroscopy team using MICrONS data, a microglia (purple) contacts with an excitatory pyramidal neuron (gold). Slowly the axons under the feet are revealed.
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Matt Buckley
Matt Buckley@MatttBuckley·
The relationship between educational attainment (a proxy) and plasma pTau being over a threshold is SO MUCH STRONGER than I would have guessed. Basically no increase with age if you had some college. N>10,000.
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Richard Fuisz
Richard Fuisz@richardfuisz·
Some exciting news to share — we've made the world's first magnetically controlled antibody! What is a magnetically controlled antibody? It's an antibody drug that you can turn on and off, wherever you want in the body. (1/9) x.com/ashleevance/st…
Ashlee Vance@ashleevance

Big scoop this morning on the site from @eryney_ok. We destealth @richardfuisz's new company @NonfictionBio, which is working on more precise cancer therapies that don't kill you as they treat you. corememory.com/p/exclusive-fr…

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Keşfet

@CellularIntelHQ @novonordisk @MichaBreakstone @JonathanAnomaly @herasight @clairebedbrook @ravi_nath @BrunetLab