Maxime Meylan

Excited to share our latest study published in @CellCellPress !! We uncovered that a single oncolytic virus injection can ignite deep, persistent T cell immunity in glioblastoma, lasting months to years. sciencedirect.com/science/articl…

PICI researcher Kai Wucherpfennig, MD, PhD, of @DanaFarber’s research shows a single injection of an oncolytic virus can trigger lasting T cell immunity against glioblastoma. Read more about the study and its impact here: bit.ly/4suBcRe

Nice summary of our study by @ACIR_org ! Read it here : shorturl.at/jj4Vj

Now online! Persistent T cell activation and cytotoxicity against glioblastoma following single oncolytic virus treatment in a clinical trial dlvr.it/TQvdv2

A new study led by @DanaFarber’s Dr. Kai Wucherpfennig and colleagues shows that an injection of a genetically modified virus that selectively infects and destroys cancer cells can recruit immune cells to penetrate and persist deep within brain tumors. ➡️ bit.ly/4atTuee

🚨Paper alert 🚨 Check out our latest paper: We identified SPP1 as a key regulator of mesenchymal cell fate. Together with GREM1, SPP1 regulates reciprocal epithelial and mesenchymal PDAC cell fate. 📚Read more about this @Nature paper below ⬇️: nature.com/articles/s4158…

@aaronmring @Yile_Dai @Nature @fredhutch @FH_IRC @YaleCancer @YaleIBIO @Seranova Amazing work congrats @aaronmring @yile_dai and team! Was dying to know more about these AAB targets and functions!

T cells do the heavy lifting when it comes to the anti-tumor action of checkpoint immunotherapy. But do antibodies play a role too? That’s the question @yile_dai looked to answer in his thesis work, out today in @Nature! 🧵below nature.com/articles/s4158…

@SizunJ @GuillaumeJaume @AI4Pathology @mshaban_ai @Yuzhou_Chang @yeoyaoyu Awesome @SizunJ looking forward to trying it out!

Chuffed to share KRONOS: A foundation model for Spatial Proteomics! arxiv.org/abs/2506.03373 Exciting work with the indomitable @AI4Pathology, led by the amazing @mshaban_ai, @Yuzhou_Chang, with Huaying, @yeoyaoyu, @GuillaumeJaume, Andrew Song, and our collaborators

@LukasValihrach Amazing paper! Which method is your favorite?

Cell-type deconvolution methods for spatial transcriptomics🤟 nature.com/articles/s4157…

1/ 🧵Excited to share our latest study published in @NatureCancer co-led with amazing co-first authors and friends @TJammihal and @ChrisLabaki under the exceptional mentorship of @DrChoueiri @BraunMDPhD @ShuklaSachet nature.com/articles/s4301…

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In a new Science study, researchers report that cancer cells can be reprogrammed in vivo into dendritic cells that can activate T cells and promote antitumor immunity. Learn more ⬇️ 📄: bit.ly/4eS9Y0L #SciencePerspective: bit.ly/4eUiHPW

I haven’t posted much since Twitter is X, but I have a good reason today☺️ if you like #cancerstemcells #stemcells and #immunotherapy, this is for you! With partner in crime Phoenix Miao😎 nature.com/articles/s4156…

Exiting new method, looking forward to trying it!

Check out our new article in @NatureRevCancer where we take a deep dive into early myeloma and discuss the potential of T cell-redirecting therapies! nature.com/articles/s4156… @IrenemGhobrial @JbAlberge @LucaBertamini and Rosa Toenges @DanaFarberNews #mmsm

Happy publication day for us! Labor of love with @CoffmanLab #TLS #ovariancancer @UPMCHillmanCC @PittTweet The activity of tertiary lymphoid structures in high grade serous ovar... sciencedirect.com/science/articl…

CAST enables physical alignment of spatial omics data across replicates, techs, modalities at single-cell resolution. Such accurate alignment enables spatial atlas searching, unbiased DEG identification, and reconstruction of spatial multi-omics. DM for questions and collabs!

Happy to share Novae, our new foundation model for spatial transcriptomics data 💫 Load a pre-trained model and start using Novae in two lines of code! biorxiv.org/content/10.110… github.com/MICS-Lab/novae

Benchmarking clustering, alignment, and integration methods for spatial transcriptomic. #SpatialTranscriptomics #MethodsBenchmarking @GenomeBiology genomebiology.biomedcentral.com/articles/10.11…

How is CRI-Mike Goguen Immuno-Informatics Postdoctoral Fellow @MaximeMeylan @DanaFarber discovering a world #Immune2Cancer? Fuel the future of cancer research, and double your impact today! All donations will be matched up to $300,000 only until June 30: bit.ly/3UGAKjy