Mercy Mazurek

an important and exciting direction to answer a clinical need!

“Only reading or observing can’t match! “ Mastering it means being able to draw it from memory. If you can visualize it, you truly understand it! ⬇️ My sketch of ACDF

We’re excited to share our study looking at molecular classification and survival of 4,400 #gliomas @NeuroOnc A huge team effort over the years @MGBNeurosurgery @BWHNeurosurgery @DanaFarber, here’s what we found. 1/10 academic.oup.com/neuro-oncology…

Reversible opening of blood-brain barrier is here. @NEJM study showed that low-intensity focused ultrasound can temporarily open the blood-brain barrier to augment antibody-based removal of amyloid plaque in patients with Alzheimer’s disease by up to 63%. nejm.org/doi/full/10.10…

Cool study in @ScienceMagazine shows that stimulation of the human primary sensory cortex can produce reliable finger sensation, thus combining stimulation in different locations, amplitude, and duration can restore feelings of shape and motion. science.org/doi/10.1126/sc…

What if you could target brain regions important for recovery after spinal cord injury with DBS? Can you say hypothamamus? Guess what Cho and colleagues from Switzerland did just that in a brilliant new paper @NatureMedicine. Key Points: - People don't think about it, but guess what, spinal cord injury 'disrupts the neuronal projections from the brain to the region of the spinal cord that produces walking.' - The authors wanted to know what brain regions would steer recovery following spinal injury. - They cleverly made a space–time brain-wide atlas of 'transcriptionally active and spinal cord-projecting neurons.' - What region lit up? The lateral hypothalamus. - Specifically glutamatergic neurons. - They tested in mice and it helped. - They tested in two humans and it immediately improved walking. My take: WOW. A little serendipity in that no one expected that the lateral hypothalamus was important for mediating recovery of walking in incomplete spinal injury. We have been in the lateral hypothalamus for DBS in humans for obesity and other symptoms and, we will need in future experiments to monitor body weight, psychological status, hormonal profiles, and of course autonomic functions. What I love about this study was the path the scientists and clinicians from Lausanne took. A space–time brain-wide atlas, followed by mice, and then two actual humans. BRAVO! Excited to see what comes next. nature.com/articles/s4159… #deepbrainstimulation #neuromodulation

In a new @NatureComms study, researchers from the lab of @wtkimberly at @MGHNeuroICU demonstrated that a portable MRI shows promise for expanding brain imaging for #Alzheimer's disease. Read more: massgeneralbrigham.org/en/about/newsr… doi.org/10.1038/s41467…

New research demonstrates that DBS of the motor thalamus improves arm and hand function in individuals affected by #TBI and #strokes, offering a potential breakthrough in neurorehabilitation. @AANSNeuro @CNS_Update #ASSFN #neurosurgery #medtwitter #MedX nature.com/articles/s4146…

Fantastic, authoritative & comprehensive ‘roadmap’ article out in @NatRevNeurosci by Segobin et al. about in vivo segmentation of the thalamus. nature.com/articles/s4158…

Excited to share my lastPhD publication! We discovered non-inherited mutational patterns in schizophrenia occurring before birth. Huge collaborative effort w/ @seplyarskiy @jones_attila science.org/doi/10.1126/sc…

I am super excited by this figure just published by @MalloryHacker et al. – why? Let’s unpack… 🧵 #citeas" target="_blank" rel="nofollow noopener">link.springer.com/article/10.100…

Thanks to @ERadSociety for having me— was great to present some of the work we’re doing @meshincubator to implement AI in ED workflows!

Anatomy of the internal capsule... the internal capsule is a white matter structure located between the caudate nucleus & thalamus (medially) and the lentiform nucleus (laterally) and is traversed by several important white matter tracts... #MedEd #RADEd #FOAMed #Radres #FOAMrad

Are we too cortex exclusive? 🧠 We found that perceptual decisions depend on a cortical pathway through thalamus (transthalamic), even though corticocortical projections are intact. Transthalamic pathways thus play a major but underappreciated role in perception. 1/5

New @YaleRadiology low-field MRI review! 🧲 Great summary of hardware/software advances behind today's innovative scanner designs & applications. 📰: doi.org/10.1146/annure… 👏 @samardzija_anja @kartiga_selva @HoraceZ_Zhang @HSun981 @chenhaosun22 @GigiGaliana @constable_todd

Beautifully-written article about @BryanDChoi @MGHCancerCenter @MGHNeurosurg 's CAR T-cell trial for GBM. Proud to be working in the Choi lab during this exciting time! nymag.com/intelligencer/…

Such an incredible piece! I am so lucky to have the privilege to learn medicine alongside @michellembosche and am very thankful for you sharing these reflections

Think you know brain vascular anatomy? How many brain vascular circles do you know? Everyone knows the Circle of Willis, but few know its venous counterpart: Venous Circle of Trolard! Can you see the polygon on top of a❤️?? Venous Circle of Trolard is the midline connection between the right & left venous networks. Peduncular veins form the so-called “mesencephalic heart.” It provides venous collaterals in both the transvesrse & AP directions It could potentially compensate in contralateral basal occlusion from tumor or surgical injury. On the flip side--in a dural AVF, it could result in hemorrhage on the contralateral side! Hopefully now when it comes to venous anatomy, you will always bee in the right vein!

The supplementary material of this study is a hidden gem for anyone interested in neuroanatomy of subcortical tracts! This should be a textbook. nature.com/articles/s4146… static-content.springer.com/esm/art%3A10.1…