METANOVA

@brian_armstrong Next-gen human enhancement drug screening @metanova_labs in progress

Some of the most underinvested areas in frontier biology that could accelerate civilizational progress: - Cheap, large-scale DNA synthesis (writing entire chromosomes or full organisms) - Real-time, non-destructive RNA sequencing in living cells - Highly accurate AI-powered polygenic scores for complex traits (disease risk, cognition, longevity) → enabling full genome design - Ultra-precise, multiplex genome editing (far beyond CRISPR) with minimal off-target effects, scalable across millions of cells - Safe, efficient, tissue-specific in vivo delivery systems - Safe and effective human germline engineering - Accelerated clinical trials via testing on decedents (with consent) - Next-gen human enhancement: muscle, cognition, mood — beyond GLP-1s - Ectogenesis / artificial wombs Who’s actually building in these areas? Drop names, companies, or researchers below 👇

Next-gen human enhancement: muscle, cognition, mood — beyond GLP-1s @metanova_labs metanova-labs.ai/dashboard

Great conversation, well worth listening to this episode of the @supercyclepod Subnet 68 (Metanova) compresses the typical discovery stage; another aspect of Bittensor that's reshaping traditional industries I'll link the full @KhalaResearch report below

on @bittensor and @metanova_labs 👇

@supercyclepod 🫡🫡🫡

Jack on Metanova SN68

First NOVA Blueprint bounty paid out since upgrade New winner: 1. Learned which reactants actually produce signal 2. Biased generation toward what works 3. Increased memory (150 → 500) 4. Coordinated global search (DJA) with local search (tabu) 5. Added anti-plateau dynamics Net result: A more adaptive, memory-rich, and directed search process. Blueprint is working as intended: Optimizers themselves are evolving under competition 🔗 metanova-labs.ai/dashboard #Bittensor #SN68 #DrugDiscovery

You don't need a biology degree to help find new drugs anymore. @metanova_labs turned drug discovery into a search and optimization challenge. Engineers, researchers, and AI agents can compete globally to find new candidates. How Bittensor Subnet 68 works 👇

NOVA Blueprint incentives are evolving. We’re moving to a bounty-based payout model: - No improvement → no reward - Real breakthroughs → full bounty Emissions now accumulate and are only paid out when a new submission meaningfully beats the current best. Our rewards will scale with difficulty. Learn more in our channel: discord.com/invite/bittens… #Bittensor #SN68 #DrugDiscovery #DeAI #DeSci

$TAO sn68 CEO explains NOVA system 2 mechanisms for NOVA miners 💊 ⛏️ > submit molecules of interest > power chemical search algorithms drug discovery is leveling up 🧪

How do decentralized networks build resilience? There’s a "warm-up" phase when new subnet get created. It isn't just a learning curve—it's an adversarial stress test. By trying to game the system, miners expose critical areas of low confidence in in these models. This behavior creates a mechanism that forces constant iteration to align incentives toward more valuable outputs.

ICYMI: @micaelabazo and @pennapdr on @twistartups talking about NOVA and decentralized drug discovery with @MaxScore from @webuildscore and @Tom_dot_b from @Bitcast_network thanks for having us @alex @Lons

see you soon

the final frontier for AI is science that’s where the most consequential value will be created and captured in this new era companies will compete to build continuously improving systems that drive breakthroughs in human health and experience we got a head start @metanova_labs powered by #bittensor and open for anyone to participate stake, mine, or partner with us to accelerate decentralized drug discovery we got a role for you and your agents

Learn more about our growing agent ecosystem in @opentensor Novelty Search: 1. Clyd: subnet ops + miner submissions analytics 2. Novalyst: subnet discord user guide 3. ArboNOVA: chemical analysis + hit picking assistant 4. ArboPatents: autoresearch for patent-molecule matching 34:25 min -> youtube.com/watch?v=d1_u8E…

For anyone trying to understand Bittensor from first principles, this lecture is a useful place to start. Presented by Bittensor co-founder @const_reborn. Learn Bittensor > Start with Bitcoin, distributed systems, incentives, > How Bitcoin leads to Bittensor Subnets coordinating AI infrastructure. Topics: // Start - Bitcoin as more than a digital currency // Risks of AI centralization + closed systems // "The incentive computer" // How Bittensor subnets work (mining, validating) // How distributed AI infrastructure could scale globally // Impact on students, builders & future founders Recorded at the National University of Singapore Computer Science Club. @NUSComputing Chapters - Bitcoin, AI, and Bittensor - Bitcoin history and decentralization - AI changes how engineers work - The danger of centralized AI power - Why most crypto visions fail - Bitcoin as the world’s largest compute network - Bitcoin as a market for compute - The idea of an “incentive computer” - Bitcoin compared to Bittensor - Classroom example of decentralized scoring - A simple subnet example - SN62 :: @ridges_ai SWE agents - SN3 @tplr_ai :: Distributed AI Training - SN52 @lium_io :: GPU rentals on Bittensor 128 subnets, some examples Why this matters for the future of work Q&A Subnet examples mentioned @ SN64 - Serverless + TEE Compute :: @chutes_ai SN8 - Prop firm @VantaTrading SN52 - AutoML :: @gradients_ai SN62 - SWE agents :: @ridges_ai SN51 - Compute / GPU rental @lium_io SN4 - TEE compute for enterprise :: @TargonCompute SN3 - 72B Distributed Training run :: @tplr_ai SN41 - Prediction markets :: @almanac_market SN44 - Computer Vision @webuildscore SN68 - Drug discovery :: @metanova_labs SN18 - Weather Forecasting @zeussubnet SN50 - Bitcoin prediction data :: @SynthdataCo SN61 - Quantum computing :: @qBitTensorLabs SN14 - Bitcoin mining pool :: @taohash SN34 - Perp Dex :: @0x_Markets SN17 - 3D model generation :: @404gen_ SN33 - Data analytics :: @ReadyAI_ SN19 - [Since relaunched] RPC infrastructure :

ArboNOVA: our Patent-Molecule loop ft👇

Welcome to all our new followers! or if you’ve been sidelined, this is your entry point to NOVA Meet Novalyst: our on-demand guide (by @urdof07) Ask it anything: • How scoring, emissions, and competitions work • Who’s winning and why • How to read the leaderboard + track your submissions • What a metric, API response, or config actually means • How miner strategies differ under the hood It can also: • Break down code + algorithms into plain english • Trace submission history and behavior across epochs • Summarize what’s actually happening in the subnet in real time And more! Come learn, explore, and start mining today: discord.com/invite/bittens… #Bittensor #SN68 #DrugDiscovery #Agents #DeSci

ArboNOVA: Patent–Molecule matching loop We’ve been experimenting with an agent that maps molecules → prior art using only open data + tools Benchmark: ~1500 molecules across ADHD-related patents (since 2012) In ~12 hours: 18 iterations of the loop → Best hit rate: 85.4% How this is usually done: Pharma intelligence teams + expensive proprietary databases + manual workflows + even conference attendance Early, but promising. Moving one step closer toward automating drug discovery and identifying which molecules are most strategic to advance in the wet lab. Based on @const_reborn (github.com/unconst/Arbos) and @karpathy autoresearch framework #Bittensor #SN68 #ralphloop #agents #DrugDiscovery #Desci #DeAI

6 months ago I lost my father to complications from chemotherapy. he beat pancreatic cancer against all odds, but the treatment ironically ended up killing him. I never stopped working on @metanova_labs because I believe *we* can do better. if you’ve ever struggled to direct your life, if you’ve ever felt powerless in the face of disease, if you’ve ever lost someone, then you understand there is nothing more important than medical innovation. for the first time in history we have the technological primitives to tackle the world’s most important problems. I would argue health is #1 on that list. with #bittensor you can fund and co-own these solutions. it's an opportunity to participate in and help shape the building of a new world. join us today.