MrCharless

I’m a heartbreaker, my name’s Charles

Make friends with your inner demons✨ 🎨 lumierebelge

real super-intelligence starts at the ability to decode animal language without training data. I want to talk with my pets. now we know how to do it. it's in-context grammar induction, which is also policy induction. dynamic weight revision is nerd snipe. the context window is already your buffer for memory. the actual problem is that english is not optimized for density or representation, it's optimized for discussion and chatting. it's not a language of storage and representation. the weights should be thought of as a perceptual kernel, a rule set for inference. the more rules you can pack the better. I would actually try to evacuate as much of the knowledge out of the weights, into exchangeable illegible non-english representations that are maximally packed, the zip file equivalent in context as tokens. for this you need to apply RL in a way that grows and mutates language autonomously. what you actually want is in-context compression. that's mesa optimization. you want to redo the whole base model training section in RLVR. your weights can shrink massively, and your world model is simply a huge text substance prepended to the context window. now your model is disentangling. microscopic model that remains efficient to opus 5 level at least. but it churns tokens at light speed. you probably don't even do conversation turns anymore, you pack the last user/assistant turn immediately into a representation, remove the messages, and the model replies as though it was still there, because the packing can encode recent packs at a higher resolution. or it can maintain separate representations if that's easier to engineer for now, maintain a long-term memory representation. but actually not really-it gets even better when you transition this into dLLM-obviously not causal sequential inference pattern but more like RLVRed for perpetual representation search and defragmentation. now you have a live self-mutating memory substrate that is alien and magical x.com/ryunuck/status…

When you breathe in, the longer you hold that breath, you destroy Daily Repeating Patterns on those seconds of the night/day That's how easy it is to begin changing your reality — Destroy the repeating patterns with Breathing Practice simply by holding your breath longer Regularly. The more focus you put on your Breathing, you gain more power/control over your reality. The more you practice the Breathing Arts, you will begin seeing Geometric patterns and shapes in your mind (your Eye). When destroying repeating life patterns, the spinning shapes go counter-clockwise. This is how you reverse negative astrological chart patterns. Rather than teach astrology, I find it more powerful to tell you the one technique that allows you to control Everything (holding your breath).

Gintama is the only anime to have a failed opening 😂

🗳️📌 DERRAME DE PETRÓLEO YA RECORRE 630 KM… Y NADIE SE HACE RESPONSABLE El derrame de petróleo en el Golfo ya alcanzó 630 kilómetros. Va desde Veracruz hasta Tabasco. Hay 51 puntos con chapopote reportados. Y afectación directa a ecosistemas y comunidades. Se reporta la muerte múltiple de: - Tortugas. - Delfines. - Manatíes. También hay daño en manglares y zonas protegidas. Para empeorar, hay daños económicos. Pescadores llevan demasiados días sin poder trabajar. Y no hay indemnizaciones, porque nadie asume la responsabilidad. La información y mapa es de @proceso

"When you study natural science and the miracles of creation, if you don't turn into a mystic you are not a natural scientist. Outside is pure energy and colorless substance." ~ Albert Hofmann

Pavo Que le dijo un pavo a otro pavo?

I don’t know what that show is about but it seems to have a weird Trump and a geisha I am more interested in the geisha 🤣

If I intentionally don't examine my life, does that mean I don't have to be responsible for the results of my actions? Or does it just mean I don't reflect long enough to care?

@whyarethis Second Option, intentionality is the key factor here. At least the second one does not remove responsability 🤣

A perfect partnership

👁️ South Korea’s Breakthrough in Eye Regeneration — A New Hope for Blindness South Korean scientists are making remarkable progress in restoring vision through cutting-edge bioprinting, stem-cell therapy, and advanced neuro-integration technologies. Researchers at KAIST and other top institutes are developing eye tissues and visual systems that could transform the future of blindness treatment. Here’s what the teams have achieved so far: 🔬 3D-printed corneal tissue created with human cells and advanced bio-ink 🌈 Lab-grown retinal layers that can sense light and transmit neural signals 🧬 Bioengineered scaffolds supporting optic-nerve repair in cutting-edge experiments 💧 Smart hydrogels designed to mimic the natural lens and corneal surface ⚡ Next-generation bionic retinal implants enabling perception of shapes, contrast, and motion These innovations are opening the door to powerful new therapies for conditions such as retinal degeneration, corneal injury, macular disease, and inherited vision disorders. South Korea’s work is building a strong scientific foundation for future treatments that blend bioprinting, stem-cell regeneration, and neural connection technologies — offering genuine hope for millions living with vision loss.

Classic Hunter S Thompson quote 🦇

En Washington, me reuní con el director del @FBI @FBIDirectorKash Kash Patel, en representación del Gabinete de Seguridad. Reafirmamos que la cooperación bilateral, basada en la reciprocidad, el respeto a nuestra soberanía y la responsabilidad compartida, permite avanzar con resultados concretos. Derivado de este intercambio de información, autoridades mexicanas han detenido en nuestro país a varios objetivos incluidos en la lista de los más buscados del FBI, así como la detención de otros generadores de violencia que afectan a nuestro país. Seguiremos trabajando para reducir la violencia en México, en cumplimiento de la instrucción de nuestra Presidenta @Claudiashein .

The word woke literally doesn’t mean a thing any more. It probably never did.

🚨MAJOR NEW PAPER 🚨 just out in @JAMAPsych : Psychedelic Therapy vs Antidepressants for the Treatment of Depression Under Equal Unblinding Conditions (tinyurl.com/yu2rbtaf). I am very proud of this one, was a lot of work for me - both co-first and last author! Eternal gratitude to co-first @QuantPsychiatry and twitterless Hannah Barnett! The premise is that it is biased to compare open-label trials (=where patients know what treatment they are getting) to blind trials (=where patients do NOT know what they are getting). Open-label trials would gain an unfair advantage by higher placebo response. Even formally blinded psychedelic trials are practically open-label as its obvious to distinguish placebo from 25mg of #psilocybin. In contrast, traditional antidepressants (SSRIs/SNRIs) trials are are close to be truly blind (Lin 2022). Given the bias of open-label vs. blinded comparison, we compared the efficacy of psychedelic-therapy (which is practically always open-label) vs. open-label antidepressants for the treatment of major depression. We tested 3 prior hypothesis: - There will be a significant difference between psychedelic-therapy vs. open-label antidepressants, favoring psychedelic-therapy. - There will be a significant difference between blinded and open-label antidepressants trials, favoring open-label. - There will NOT be a significant difference between blinded and open-label psychedelic-therapy, as practically they are always open-label. In contrast with our prior hypothesis, we did not find psychedelic-therapy to be more effective than open-label antidepressants (H1). Not only was the difference not clinically meaningful, but practically there was no difference at all. This finding means that antidepressants administered knowingly to patients, which is the case in real-life medical practice, is as effective as psychedelic-therapy. This result was robust across variations in study selection, including when we removed psychedelic-therapy trials on treatment-resistant depression. We also assessed the impact of blinding in both psychedelic-therapy and antidepressants trials. We found that for antidepressants (H2), but not for psychedelic-therapy (H3), open label is associated with better outcomes than blinded treatment. However, even in the case of antidepressants, the difference was practically small (~1.3 HAMD units). How come hypothesis 1 failed, i.e. that psychedelic-therapy is no ore effective than open-label antidepressants, given that antidepressants trials are famous for small drug-placebo difference (~2.4 HAMD units), while psychedelic-therapy trials reported large effects (~7.3)? The key factor is that in psychedelic trials the placebo response is about 50% relative to antidepressants, ~ 4 vs 8 HAMD units (Hsu 2024, Hieronymus 2025). This suppressed placebo response leads to an inflated between-arm difference, as the treatment arm is measured against a lower floor. The suppressed placebo response in psychedelic-therapy trials is likely attributable to the ‘know-cebo’ effect, i.e. the disappointment when patients realize they are in the control group. In psychedelic-therapy trials, this placebo suppression accounts for 4.0 / 7.3 ~ 55% of the specific treatment effect. In other words, ~55% of psychedelic-therapy’s effect is not explained by patient improvement after the treatment, but rather by the lack of improvement in the placebo group. In summary, we found that for the treatment of depression, psychedelic-therapy is no more effective than open-label SSRIs/SNRIs. Our results for psychedelics are twofold: psychedelic-therapy demonstrated a robust and large therapeutic effects (~12 HAMD units), which justifies optimism. On the other hand, psychedelic-therapy’s lack of superiority compared to open-label SSRIs/SNRIs highlights the influence of blinding integrity and argues against overly optimistic narrative's about psychedelic-therapy's potential.

Monster Burger

Visiting the island of Socotra in Yemen can seem like you’re on another planet. 307 out of the 825 or 37% of the plant species found on the island isn’t found anywhere else on Earth, including these dragon blood trees.

“Honey there’s a bug on the bathroom floor can you kill it?” The bug: