Will Bailis @metaBailism trying to figure out the inner works of our beloved mentor Richard Flavell @FlavellLab using two exceptionally handsome scientists
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Roni Nowarski
47 posts
Roni Nowarski
@NowarskiLab
Studying how interactions between tissue and immune cells shape immunity and inflammation @harvardmed and @BrighamWomens
Katılım Mayıs 2023
87 Takip Edilen202 Takipçiler
Beyond excited to share our #NewPaper in @CellCellPress! Inflamed environments acidify intracellular pH. BRD4 senses this via transcriptional condensates, tuning #macrophage responses to match demand and consequences of inflammation. #inflammation #pH authors.elsevier.com/sd/article/S00…
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48h since lab destroyed 😭😭 People safe, thx god. Deeply thankful @_MichaelBaumann @DKFZ & Otmar_Wiestler @helmholtz_en for reaching out to us w leadership & support. Will continue updating on support and leadership, while considering w colleagues our next chapter- suggestions?
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Roni Nowarski retweetledi
Speakers from @BrighamWomens/@harvardmed, @cwru, @cinvestav will provide insights into various aspects of innate and adoptive #immunity in #inflammation. Check out the full #Pathobiology2025 program bit.ly/3yOeuxu
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Imagine there's no treatment
It's easy if you see
Nothing to fight your cancer
Or autoimmunity
Imagine all the research
Ceasing to exist
Woo-hoo hoooo
Elon Musk@elonmusk
Can you believe that universities with tens of billions in endowments were siphoning off 60% of research award money for “overhead”? What a ripoff!
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Astrocytes are ‘lovely’, right?
@NowarskiLab @QuintanaLabHMS
In vitro astrocytes labelled with GFAP (purple) imaged on an LSM880 confocal through the NeuroTech Studio @BWHNeurology
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@elonmusk Academia is also the place where we unlock the secrets of life and the universe, harness our immune system to fight disease, and advance all aspects of life. It really all comes down to personal motivation and integrity. "The scientist is the true warrior" - Aaron Ciechanover
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Academia and some “think tanks” are the origin of the extinctionist mind viruses
Gad Saad@GadSaad
Every single dreadful parasitic idea that is destroying the West stems from academia. It begins there but then these ideas escape the Ivory Tower and parasitize everything. @realDonaldTrump's victory on Tuesday is good news in that the majority of decent people reject this nonsense BUT the battle won't be won until all of these ideas are permanently eradicated along with the reflex for suicidal empathy. Hence, the current victory is great but step 1 of a very long process of de-lobotomizing all of academia and its offshoot intelligentsia.
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@Dr_ImmunoMan_D @ImmunityCP Congrats on the beautiful work Davide! 👏
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Our work is finally out in @ImmunityCP !
Here you can download it:
authors.elsevier.com/a/1j%7E9A3qNrU…
A thread of our findings 🧵....
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Celebrating a paper accepted from a talented Postdoc @PiccoloEnzo and in colab with a good friend and colleague @thorplab neutrophil Hifs in heart injury
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A terrific synopsis of bistability in innate immune signaling by Jayajit Das and Giuseppe Giuliani, previewing our paper on macrophage tolerogenic memory published today @Immunity cell.com/immunity/abstr…
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@WiringTheBrain Very useful framework to think about proteins. Perhaps we can put another layer onto it - structural flexibility. Enzymes and receptors should fall on the right side of this axis, while unstructured proteins should fall on the left, and potentially display more properties
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A lot of molecular and cell and developmental biology is concerned with figuring out the "functions" of various proteins. I'm starting to distrust that formulation...
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Happy to announce that I am officially promoted to Full Professor at Harvard Medical School! A very special thank you to my mentor @KuchrooLab and my trainees who trusted me with their careers!
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A Cellular Atlas of Gut Inflammation the-scientist.com/a-cellular-atl…
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Roni Nowarski retweetledi
Our new work published today @NatrureMedicine nature.com/articles/s4159…
The work led by Neta Rosenzweig (@NetaRose11) and Kilian Kleemann (@KilianKleemann).
Thanks to our collaborators @EggenBart, @BlurtonJonesLab, @ReisaSperling @weinerlabhms @NowarskiLab
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@MoffittLab @AriSarfatis Extremely cool Jeff!! Congrats to the team!
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So excited to announce our new method for multiplexed RNA imaging in bacterial cells: bacterial-MERFISH! A huge congratulations to the team of @AriSarfatis, Yuanyou Wang, and Nana Twumasi-Ankrah! Check out the following thread or our bioRxiv (biorxiv.org/content/10.110…) 1/12
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Roni Nowarski retweetledi
Why are there so few drugs that target innate immune signaling pathways? Maybe bc we know so little about the natural protein interactions (and dynamics) that mediate innate immunity. A bottleneck for drug discovery may be understanding endogenous innate immune cell biology.
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@jkagan1 The pLot thickens! Congrats Lauren and team Kagan for this important discovery introducing new innate immune warriors!
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Move over STING, TRIF and MAVS. IRSp53 and GMIP join the club of pLxIS proteins that stimulate interferons. So pleased to share our new study, which used synthetic biology to reveal multiple mechanisms that lead to anti-viral immunity. With a surprising link to metabolism.
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Roni Nowarski retweetledi
New research from @NowarskiLab uncovers a 'switch' in the gut that can provide protection against harmful intestinal inflammation. The work was published in @ImmunityCP buff.ly/3z8n35V
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Very excited to share our paper showing that IL-18 activation of the salt transporter NCC programs durable immune tolerance in the gut! We found that NCC induces a metabolic switch in macrophages that stabilizes fatty acid oxidation and prevents glycolytic reprogramming ⬇️
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