NetaRosezweig

Thrilled to share our invited Nature Reviews Neuroscience review on the role of peripheral immunity in Alzheimer’s disease. Honored to write this piece with outstanding colleagues @KuchrooLab, @RudyTanzi, @weinerlabhms, Mehdi Jorfi and rising stars from my lab Neta Rosenzweig and Kilian Kleemann. My sincere thanks to Editor Katherine Whalley for the invitation. The time has come to deeply investigate peripheral immunity in AD.

organoids, while a powerful tool for studying human biology, lack immune systems, which is a significant limitation. NIH prioritized organoids to model human tissues and diseases in vitro. However, their lack of an immune system hinders their ability to fully recapitulate human physiology, especially for studying immune-related processes or diseases involving immune responses, like Alzheimer’s and Cancer

Thrilled to share invited review with the brilliant @NetaRose11! in the @ImmunityCP special issue on neuroimmune interactions. We explore shared immune pathways in Alzheimer’s & AMD, and chart new directions for cross-disease therapeutic strategies. cell.com/immunity/fullt…

Online now: Alzheimer’s disease and age-related macular degeneration: Shared and distinct immune mechanisms dlvr.it/TKZSH4

Common immune system mediated threads of Alzheimer's disease and age-related macular degeneration, a new open-access review cell.com/immunity/abstr… @ImmunityCP

APOE4-dependent neutrophil-microglia interactions drive cognitive impairment in female individuals with Alzheimer’s disease via IL17F @ButovskyLab, @OlegButovsky, @NetaRose11, @KilianKleemann #neutrophils, #microglia, #IL-17 nature.com/articles/s4159…

@BrighamResearch @ButovskyLab @OlegButovsky @KilianKleemann @OlegButovsky

Research Spotlight: Uncovering How a Cellular Miscommunication Leads to Cognitive Impairment in Female Patients with Alzheimer’s Disease buff.ly/4d1NmJT @ButovskyLab @OlegButovsky @NetaRose11 @KilianKleemann

@NatureNeuro Looks like eyes 🧿

Our July issue is now live! nature.com/neuro/volumes/…

Sex-Dependent APOE4 Neutrophil–Microglia Interactions Drive Cognitive Impairment in Alzheimer’s Disease stemcellsciencenews.com/newsletter/228… via @Science News

This work led by Neta Rosenzweig (@NetaRose11), @KilianKleemann, & Thomas Rust provides a translational basis to target IL-17F in APOE ε4 female carriers with cognitive impairment. 🧠 Congratulations to all the authors! @OlegButovsky @EggenBart go.nature.com/4eZef2H

@NatureMedicine @ButovskyLab @OlegButovsky @NetaRose11 @KilianKleemann Any Clinical development incoming of bimekizumab for Alzheimer Disease @UCB_France ?

@NatRevNeurol @OlegButovsky

Sex-dependent APOE4 neutrophil–microglia interactions drive cognitive impairment in Alzheimer disease nature.com/articles/s4159…

APOE4-dependent neutrophil-microglia interactions drive cognitive impairment in female individuals with Alzheimer’s disease via IL17F @ButovskyLab, @OlegButovsky, @NetaRose11, @KilianKleemann #neutrophils, #microglia, #IL-17 nature.com/articles/s4159…

@PAULJLAMONT @OlegButovsky @KilianKleemann @EggenBart @BlurtonJonesLab @weinerlabhms @NowarskiLab Very interesting point! I’ll read this in details. We did not look at astrocytes specifically in APOE4 carriers, but it makes sense to me in light of previous findings that APOE4 impairs mitophagy in astrocytes.

Our new work published today @NatrureMedicine nature.com/articles/s4159… The work led by Neta Rosenzweig (@NetaRose11) and Kilian Kleemann (@KilianKleemann). Thanks to our collaborators @EggenBart, @BlurtonJonesLab, @ReisaSperling @weinerlabhms @NowarskiLab

Our new work published today @NatrureMedicine nature.com/articles/s4159… The work led by Neta Rosenzweig (@NetaRose11) and Kilian Kleemann (@KilianKleemann). Thanks to our collaborators @EggenBart, @BlurtonJonesLab, @ReisaSperling @weinerlabhms @NowarskiLab

Another tour de force from @OlegButovsky lab further expanding our understanding of the APOE biology in Alzheimer’s disease. Congrats to the entire team of authors!