Patrick Renner

@briannekimmel Might also slow you down if you raise from the wrong investors

Raising money is a core part of your GTM strategy because it buys the ability to move faster than your competition - discount the product to win competitive deals & steal market share - pay resellers a higher commission - comp sales aggressively to build a talent density

@danturrentine @MarkHalperin @2waytvapp @PressSec @WhiteHouse @whca So happy for you guys! Well deserved - big fan of the show!

Well done @MarkHalperin @2waytvapp ! I have said it a few times on the show: I applaud what the @PressSec @WhiteHouse have done taking over the @whca and opening up the briefing room to new media, like ours. I wish my party would stop defending yesterday and embrace the future. Mark Halperin Makes 2WAY's Debut at White House Press Briefing youtu.be/ggn-Usi-NHw?si… via @YouTube

@brady_h Best everyday training show I’ve been running in in a while!

Boston prep Week 2/Day 5 Easy 12 miles. Zoom Fly 6 might be the most fun training shoe I’ve ever worn. I didn’t want to stop running today.

@beckylitv Nope! Doesn’t cost a dime.

The Forbes 30 under 30 costs about 15-20k if anyone was curious. Have friends that inquired.

@CanesDavid @thesamparr Same logic would apply to the what-if scenario where the nodule would have been something serious. The scan would have saved her life in this instance.

From a doctor’s perspective, these scans have many more downsides than sitting in a loud machine False positives lead to demonstratable harm There’s a reason why doctors don’t recommend full body scans and it’s not because we want cancer to go undiagnosed Screening for each cancer is a very specific calculation of risks versus benefits For some cancers, population wide screening leads to far more harm than benefit It’s very hard for people to grasp why certain things are better undiagnosed. These types of scans are pure money grab from wealthy people who can afford them. I’ll give you an example. A friend of mine who is about early 30s got one of these. It showed a nodule behind her eye. This led to a biopsy. This is a really tricky, kind of biopsy where a needle has to go behind the eyeball. The biopsy showed a benign finding. Now, what if the biopsy caused a hematoma and she became permanently blind? For something that would absolutely never have caused harm in her lifetime? Now she’s perpetually worried about this benign thing behind her eye that would never have caused a problem. Iatrogenesis is real. These scans are a terrible idea. I won’t get one nor will anyone in my family. Medicine isn’t a conspiracy theory depriving people of diagnoses. It’s data driven calculations about risk vs benefit for every potential threat. Curiosity is a dangerous thing.

Got a Prenuvo scan last month. Its a full body MRI scan. Do you remember how you used to be able to smoke in restaurants? Seems crazy today. I think in 20,40,50 years we'll look back and be like "wasn't it insane that years ago you could have cancer or something else in your body and not even know about it...and had you known, it would have been cured?" I've been obsessed with that idea for a few years now. So I love testing out products that address that. Prenuvo was pretty cool. You get a fancy waiting room, dot eh scan, then login after and see the results. Downside is that you have to sit in a loud MRI machine for like 45 minutes. Was scary waiting for the results. But thankfully, all was good. But overall, was super cool. Am thinking about getting them down annually (or something like that).

@thesamparr Have been doing a Prenuvo scan for the last 3 years. Big fan and great peace of mind. Extra points for combining this with the Galleri cancer screening.

@AriaLV what’s the deal with closing the gym at 6pm? Not really something you expect from a 24/7 town. Loads of angry guests!

@KristerKauppi Proud to have been one of his 1500 patients. RIP Dr. Green. Thanks for all the things you’ve done for the longevity community!

It is with great sadness that Dr Alan Green died last week. In 2015 he made a big change in his life because his health was declining rapidly. He started to learn more about longevity and got shocked when he could not find anything around the topic in his medical books. So instead of looking in medical books he started to read more around the research and came across the Rapamycin researcher Mikhail Blagosklonny theory of aging. This theory is about that mTOR dysregulation drives age-related diseases and that Rapamycin is a potential way of slowing this process down (pubmed: 17012837, 37477535). Based on this, Alan decided to be one of the first people to start self-experimenting with Rapamycin 6mg/weekly in January 2016 and he started to feel better. In 2017 he started a small home based clinic to prescribe Rapamycin off-label to other people and by 2024 he had 1500 patients. So Alan was not just the first pioneer physician in the field but also the person who ended up with the biggest clinical experience around off-label Rapamycin. A really big thanks for all that you have done in speeding up the research in the field, Alan! One reason why I started the Rapamycin Longevity Series podcast was to document down valuable knowledge from different physicians, researchers and other experts around Rapamycin. I’m grateful that I got the chance to have a conversation with Alan and it meant much, especially now, that he liked it (“Listened to the entire tape. You did a great job and excellent slides”). The sad thing was that Alan did not want to die. This is one reason why death really sucks because it’s currently not a choice. It’s a random event that is just forced upon us one day. Together with other dedicated people I will really try to change this and give us this choice in life 🙏 PS. The podcast was my attempt to create a digital maui statue of Alan so that he will never be forgotten. Below in the comment section you can find also others interviews with him throughout the years. Miss you my friend!

@billionsmustliv @eperlste Nothing major but my main focus is really on prevention/slower aging. I always tell people that this is not a wonder pill but a nice add-on to exercise and eating healthy.

@PatrickORenner @eperlste have you noticed anything

Meeting more and more biotech founders in their 30s and 40s who are taking low-dose rapamycin.

@eperlste I actually started with a lower dose (3mg) the first 3 months to see how things go. Never heard someone starting higher and then taper.

@PatrickORenner 5-7mg weekly seems to be the consensus. Did you go higher and then taper?

@eperlste I take 5mg/weekly.

@PatrickORenner what's your dosing regiment if I may ask?

@biogerontology @EricTopol Would love to contribute!

Nice mention by @EricTopol . My take on Rapamycin and rapalogs - unlike other drugs, there is evidence of life extension in pretty much every other species. In humans, the effect may be even stronger, there may be no effect, or it may be mildly harmful (seems reasonably safe considering the size of the community of users). The fact that there is a community of scientists using it on themselves is a good thing. We just need to see them publishing self-experimentation data. Otherwise, they will just die without leaving any data and we will never find out. In 2014, I proposed establishing a Journal of Self Experimentation (JoSE) and made a very cool video to kick-start it. Unfortunately, I am now in a position where I can no longer do crazy things that the pharma companies and conservative investment community would condemn. But I hope that someone launches a journal like this. Maybe @EricVerdin @NirBarzilaiMD @davidasinclair @ScheibyeKnudsen know someone who would be interested in launching a journal in this area. Good idea to discuss at the @ARDD_Meeting

@CoachKastor @lamarathon Good luck 💪

Looking forward to running my second L.A. Marathon!

@zachperret Did the Techstars NYC program in 2016! Amazing memories!!

In Jan 2012, I left my consulting job to go work for Techstars NYC. Techstars was like “YC of New York” — but instead of batch dinners and partner office hours, they gave the companies full-time office space and brought in a cadre of well-known founders + investors as "mentors".

@whoop would be awesome if one could link the @MyFitnessPal app to track nutrition automatically. Using the journal at the moment but an integration might make this a lot easier.

Thank you @citrus_labs for sponsoring 10 families from Ukraine 💙💛

Thank you to Drummond Road Capital, @citruslabs, and @superworldapp for donating $10,000 each! These donations will go directly to help 30 families affected by the war in 🇺🇦. Join dozens of other Startups and VCs to help 🇺🇦 families: 1kproject.org/startups #StartupsForUkraine

Proud to support the @1kprojectorg with @citrus_labs! Please consider sponsoring a family if you can. Such an important cause!

@Literal_Beast @jlaz7890 @CaesarsRewards @LasVegasLocally @VitalVegas @VisitAC Did you resubmit or just waited for the match to go through?

@PatrickORenner @jlaz7890 @CaesarsRewards @LasVegasLocally @VitalVegas @VisitAC There is hope after all. I checked this morning and I'm now diamond status with them.

@CaesarsRewards doesn’t care about loyalty. Took away my Diamond status without a real answer and refuses to work with me like professionals. @LasVegasLocally @VitalVegas @VisitAC