Romain L. Valette

Big news: Rare back-to-back studies @Nature provide evidence a bile acid called LCA mediates the health & age slowing benefits of low-calorie diets, and may be the elusive endogenous SIRT1 activator that resveratrol mimics. Details below 🧵 tinyurl.com/55dxb859

The capability for producing "mirror life" is out there and poses danger. When some scientists who worked on this became aware, they stopped pursuing it, and co-authored this piece, along with over 30 leading scientists—a @ScienceMagazine policy forum that lays out the risks science.org/doi/10.1126/sc…

What if you could target brain regions important for recovery after spinal cord injury with DBS? Can you say hypothamamus? Guess what Cho and colleagues from Switzerland did just that in a brilliant new paper @NatureMedicine. Key Points: - People don't think about it, but guess what, spinal cord injury 'disrupts the neuronal projections from the brain to the region of the spinal cord that produces walking.' - The authors wanted to know what brain regions would steer recovery following spinal injury. - They cleverly made a space–time brain-wide atlas of 'transcriptionally active and spinal cord-projecting neurons.' - What region lit up? The lateral hypothalamus. - Specifically glutamatergic neurons. - They tested in mice and it helped. - They tested in two humans and it immediately improved walking. My take: WOW. A little serendipity in that no one expected that the lateral hypothalamus was important for mediating recovery of walking in incomplete spinal injury. We have been in the lateral hypothalamus for DBS in humans for obesity and other symptoms and, we will need in future experiments to monitor body weight, psychological status, hormonal profiles, and of course autonomic functions. What I love about this study was the path the scientists and clinicians from Lausanne took. A space–time brain-wide atlas, followed by mice, and then two actual humans. BRAVO! Excited to see what comes next. nature.com/articles/s4159… #deepbrainstimulation #neuromodulation

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Livestream of @Neuralink demonstrating “Telepathy” – controlling a computer and playing video games just by thinking

A new #MachineLearning framework enables robots to self-learn their morphology, kinematics, and topology. Learn more in Science Robotics: scim.ag/5b6

Our review on the use of electromyography (EMG) signals for the control of lower limbs prostheses that was recently published at IEEE Transactions on Medical Robotics and Bionics: doi.org/10.1109/TMRB.2….

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The SimBionic fellows did a great job communicating their work in Pint of Science Göttingen!!!! @MSCActions @HorizonEU @SimBionicsEU @SabinaManz @DamonteFederica @rlvalette @MassimoSartori8 @UTwente

What a great experience to share #SimBionics research with fellow scientists at @pintofscienceDE in Goettingen! Thanks to the organizers for three nights of #science.

🥳 @akaijsa & @pranavm42 et al introduce task-driven modelling of the proprioceptive system, now out in @eLife! Our work  combines deep learning & biomechanics to test theories of💪sensory representations elifesciences.org/articles/81499

We are excited to present the study protocol for the largest international randomized controlled clinical trial (RCT) ever conducted on surgical procedures for post-amputation pain. You can read the full article at doi.org/10.1186/s13063…

Huge collaborative effort with @Huawei_Wang_ , @Vikashplus, @MassimoSartori8, @SeungmoonS and @CaggianoVitt and many others🦵🙌We are not finished yet more to come😁

🔥MyoSuite 1.5 released🔥sites.google.com/view/myosuite Introducing 𝗠𝘆𝗼𝗟𝗲𝗴𝘀 (most requested feature) 🦵80 muscles, 20 degrees of freedom 💢Accurate muscle+contact+inertial dynamics ✅Locomotion baselines coming soon 👉1click-webdemo myohub.github.io/myosuite_demo

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Thank you for sharing our work! ☺️ If you did not see it yet, it is in open access at: jneuroengrehab.biomedcentral.com/articles/10.11…

This is also #phdlife! :-) @pranavm42 @SabinaManz @rlvalette

I packed-up a full-text paper scraper, vector database, and LLM into a CLI to answer questions from only highly-cited peer-reviewed papers. Feels unreal to be able instantly get answers by an LLM "reading" dozens of papers. 1/2