Yu (Ray) Zuo

Grateful for amazing mentors/collaborators @jasonsknight @YogenKanthi @JHMorrissey. Thanks to @ScienceTM 👀Prothrombotic antiphospholipid antibodies and neutrophils🕸️conspire to promote a thromboinflammatory storm in some individuals with severe #COVID19 stm.sciencemag.org/content/early/…

Check out our latest 🎙️w/@BharatKumarMD ! We dive into APS, AI 🤖, and the future of rheum research—plus an interesting APS case and a few (questionably good) jokes along the way 😄@jasonsknight @umichmedicine @APSFA #APS

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#Medscape medical news reporting on our @TheLancetRheum manuscript for #cardiovascular risk control in #Antiphospholipid syndrome with a great discussion by @RayZuoMD medscape.com/viewarticle/to…

RNA-seq study of aPL-positive patients identified 4 distinct clusters defined by gene expression modules & predicted immune cell compositions, offering potential to stratify APS & aPL-positive patients based on whole-blood transcriptomic profiles A&R doi.org/10.1002/art.70…

@APSsupportUK Another fruitful collaboration with @AliDuarteMD

🔥NETosis, mTOR, Hippo/IL-6 signaling distinguish APS subgroups. 🧬🕸️Molecular stratification may guide risk prediction and targeted therapy beyond antibodies alone. @APSsupportUK

🌟APS ≠ one disease. 👀New🔬from my lab: Whole-blood RNA-seq + unsupervised machine learning in 174 aPL+ patients revealed 4 distinct molecular endotypes. 🧬@jasonsknight @UMIntMed @APSFA #APS acrjournals.onlinelibrary.wiley.com/doi/10.1002/ar…

❤️👀 @CircAHA Microvascular Endothelial Cells License APS Vasculopathy Through YAP1- and CCN2-Mediated Signaling ahajournals.org/doi/10.1161/CI…

#CatastrophicAPS affects <1% of #APS patients, causing rapid multi-organ #thrombosis. Mark’s story shows the value of coordinated care, incl. @RayZuoMD (@umichmedicine). We’ve previously shared his work; we thank him for his work helping the APS community. cutt.ly/8rG4mPQT

Calprotectin may serve as a mechanistically informed biomarker for atherosclerotic cardiovascular disease, independent of traditional and contemporary cardiovascular risk factors and biomarkers. ja.ma/4054WbW @dranandrohatgi

🩸👀 We wrote a paper for @BloodAdvances about antiphospholipid syndrome (APS), platelets, and purinergic signaling, with an eye toward potential therapeutic targets. See the Replies for a link to the article...

NEW EPISODE! @jasonsknight joins the podcast to break down the evolving science of antiphospholipid syndrome & its treatment. From antibodies to clinical trials—this is #APS like you’ve never heard it before. LISTEN NOW → acr.tw/3GxkWg8 @ACR_Journals

A great story showcasing the cutting-edge work coming out of the #APS Program and the APS Research Labs, led by Dr. @jasonsknight and Dr. @RayZuoMD.

Catastrophic antiphospholipid syndrome completely transformed Mark Hall’s daily life. But access to comprehensive care at U-M Health has been pivotal in treating his condition and redefining what it means to live with APS. Read Mark's story on our blog: michmed.org/JDkYV

June is #APSAwareness Month! Check out the latest APS Program Update, featuring our investigators in a special article with @APSFA, add'l news & achievements, a patient's story about living with APS & What I’m Reading in APS Research by Dr. Ajay Tambralli. conta.cc/4jUou9U

Research shows #calprotectin, a marker of #NeutrophilActivation, as a potential early indicator of #AtheroscleroticCardiovascularDisease. Elevated calprotectin levels were shown to predict future #HeartDisease risk, even in individuals without symptoms: cutt.ly/arx5jbId

🚨 New from our lab! 🚨 Neutrophil calprotectin—once just a NET marker—is now unmasked as a powerful predictor of future heart disease 💔🧬@UMIntMed @APSsupportUK @TaubmanInstitut @jasonsknight ➡️ michiganmedicine.org/health-lab/how… #CardioTwitter #RheumTwitter #Atherosclerosis 🫀🧪

@AliDuarteMD @jeffsparks @DanielHSolomon @lauraandreoli80 @MariaTektonidou @Kahlenberglab @RheumNow @MithuRheum Another 🔬fruitful🍇 collaboration w/@utswheart Grateful for the teamwork and scientific synergy🙌💡

🤔 Could it help predict CVD risk in lupus or RA too? @AliDuarteMD @jeffsparks @DanielHSolomon @lauraandreoli80 @MariaTektonidou @Kahlenberglab @RheumNow @MithuRheum

🧪New from our lab @JAMACardio: Calprotectin, a 🕸️marker, predicts future heart disease even in healthy people. 🫀It damages coronary walls & promotes scarring. 🔥“Mild” inflammation ≠ harmless. #HeartHealth @jasonsknight @UMIntMed jamanetwork.com/journals/jamac…