Rosetta@Home

The COVID-19 projects on our platform are headed into human clinical trials! Our amazing online volunteers have played a role in the development of a promising new vaccine as well as candidate antiviral treatments. From the whole team at @UWproteindesign, THANK YOU! (1/2)

Our biggest change EVER! On Sept 7, we're launching new A.I. tools and a feature-packed website. • Level up your profile • Easily share your solutions • Enjoy up to 200x faster gameplay thanks to machine learning After 14 years, Foldit is still FREE and not-for-profit!

protein design

Today our admin team met with @RepJayapal to celebrate new Federal investments in 10 key projects across the Seattle area. Our request will enable the purchase of advanced laboratory equipment that will help us discover new cures for current and future pandemics.

Today we report new #deeplearning approaches for functional #proteindesign. We use these to generate immunogens, receptor traps, metalloproteins, enzymes, and binder proteins. We validate the designs using in silico and lab tests. science.org/doi/10.1126/sc…

The COVID19 vaccine developed by @KingLabIPD & @VeeslerLab has met its Phase 3 trial goals and is now under review for full authorization in Korea. SK bioscience, the company leading clinical development abroad, found the vaccine outperformed Oxford/AstraZeneca’s in the clinic.

@sahajsarup Hey Sahaj! The job queue is on and off depending on lab demand. When there are Rosetta jobs in the queue like forward folding, they should also get sent to willing arm64 clients. Thanks.

Hi @RosettaAtHome are arm64 tasks gone?

"Baker and his colleagues tested their strategy on 12 target proteins. [T]he researchers wound up with miniproteins that bound as strongly as, if not stronger than, most antibodies do." science.org/content/articl…

IPD director David Baker, together w John Jumper and @DemisHassabis of DeepMind, will receive the 2022 Wiley Prize in Biomedical Sciences for pioneering work on protein structure prediction. Their award lectures will be streamed April 1. Learn more at: newsroom.wiley.com/press-releases…

New in the feed! EBRC In Translation's @Andrew_C_Hunt and Kevin Reed interview Dr. David Baker, professor at @UW and director of @UWproteindesign, about the practical and philosophical of #proteindesign and using video games for #science. Check it out at ebrc.org/InTranslation

@TheBoinc @RosettaCommons @UWproteindesign We'll look into this. Thanks for flagging!

Please, stop the "movingstub" wus from the server!! (and test it on Ralph). @RosettaAtHome @RosettaCommons @UWproteindesign

Applications are open for our Undergraduate Summer Research Fellowships! Fellows will receive stipends as they attend seminars & conduct cutting-edge research in one of our affiliate labs in Seattle. Program Dates: Jun 21 – Aug 19, 2022 Learn more: ipd.uw.edu/join-us/

Interested in structure-based drug design? ICYMI, this news article in the October issue discusses the implications for drug discovery of the recent major advances in protein structure prediction from AlphaFold and RoseTTAFold go.nature.com/3F6vHjV

In this new video, the team at @SciShow explains how A.I. is transforming protein science. "The future of biology is starting to take shape." — @hankgreen WATCH: youtube.com/watch?v=gVzPMZ… #RoseTTAFold #AlphaFold #AlphaFold2

S. Korea has just approved a Phase 3 trial of the COVID nanoparticle vaccine we reported last year in Cell: cell.com/cell/fulltext/… All Phase 1/2 trial participants induced neutralizing antibodies. @KingLabIPD @veeslerlab @UWMedicine reuters.com/world/asia-pac…

Did you know that you (yes you) can now use the world's most advanced AI software to improve your gameplay inside Foldit? Alphafold is in Foldit❗️ Learn more in this month's Lab Report: youtube.com/watch?v=zjZJR4…

Just out in @ScienceMagazine: @UWproteindesign-led researchers present RoseTTAFold – a neural network approach for protein modeling with accuracies near those of what DeepMind’s AlphaFold2 has achieved. The tool’s code is freely available. science.sciencemag.org/lookup/doi/10.…

A big day for 3D protein structure prediction via #AI deep learning. Down to atomic accuracy w/ open-source code, methodology @nature @ScienceMagazine @DeepMind @UWproteindesign @demishassabis @UWBiochemistry nature.com/articles/s4158… science.sciencemag.org/content/early/…

In this month's Lab Report video, we share some unexpected results from the lab. + New protein structure + Puzzle updates + Design of the Month WATCH: youtu.be/dxfE3A05rzA

You too can help advance medicine and science by running Rosetta@Home to use spare computing capacity of your computer