Russell Siebert
1.9K posts

Russell Siebert
@RussellSiebert
Committed husband & father, tenured healthcare tech leader, real estate, crypto, multiple streams, health/wellness, racing cars, whiskey



Legitimately now considering driving 14.5 hours to Ft. Lauderdale this coming weekend vs. flying. Drive is brutal, but my worst nightmare is getting caught in this TSA mess flying with 3 young kids Question to those who've been flying. Is it really that bad right now?






Note: I am referring to a real thing. Early use of simvastatin comes with considerable life extension: x.com/cremieuxrecuei… And meager weight gain: x.com/cremieuxrecuei…




Muscle is going to be the new status symbol now that everyone’s on Ozempic. You better hit the gym!!


You are correct that the SV40 promoter is not a gene. However, it is incorrect to say that it cannot affect gene transcription. The SV40 promoter is one of the most potent viral promoter/enhancer elements used in molecular biology and is routinely employed to drive high levels of gene expression in mammalian cells. That is precisely why it is used in all sorts of applications. If such a promoter were integrated into the genome, particularly upstream of a gene, it could easily influence transcriptional activity. This is a well-established property of strong viral promoter/enhancer elements. And DNA integration does not require more than reverse transcription. Integration of exogenous DNA (especially linearized DNA fragments) can occur through normal DNA damage repair pathways (eg. NHEJ), particularly in the presence of double-strand breaks (DSB). These breaks arise routinely during DNA replication and can also be induced by cellular stress, inflammation, or oxidative damage. Laboratory experiments have quantified integration to be ~1-10% of cells when DNA is encapsulated in LNPs. LNP-delivered DNA is the bedrock for transgene expression after integration. This is actually the basis for gene-therapy that is used in people. Measurable integration has been demonstrated in vivo when the system is explicitly designed to create or exploit DNA breaks (i.e., genome editing contexts). For example, there are in vivo LNP-enabled DNA knock-in studies where integration is a goal and is driven by genome editing/repair processes rather than “spontaneous” integration of plasmid DNA in the absence of targeted breaks. The key scientific issue is therefore not whether integration is theoretically possible as the molecular mechanisms for it are well established. But whether it occurs from the byproducts found in the vaccines and, if so, at what frequency. We do not know the fate of the DNA present in the vaccines. No safety data has been provided on LNP-encapsulated DNA . Not having data on this 6 years after deploying the technology in people is a regulatory failure.






🔴 Senior White House Offical: Treasury expected to announce measure as soon as thursday to combat rising energy prices that includes using oil futures market.












You’re lying, either to yourself, to us, or both. Many things cause cancer. The introduction of the mRNA shots in 2021 unleashed an unprecedented wave. You and other doctors need to come clean. People have an absolute right to know what was done to them. Remember your oath.










