saaransh.eth

6) As time has gone on, however, and has been obvious to many of us for years, the prior Administration’s preference for a “vaccine boost, test, treat, repeat” paradigm has critical limitations. COVID-19 vaccination has very real and obvious limitations covered well elsewhere. Those limitations leave all of us in a form of relatively constantvirus transmission, with most of it asymptomatic, just like polio, but with a growing burden of damage in the form of Long COVID and, of course, still too much death,hospitalization, and overall sickness.  Current COVID-19 treatments may not be appropriate for everyone due to drug-drug interactions, approval for short courses only, and/or real potential for virus rebound.

One of the best responses was from an HIV antiviral. The worst response, by far, was "graded exercise".

Air pollution is an emerging risk factor for autism. 🧵1/9

Vitamin D supplementation was associated with a 40% lower risk of dementia over a decade, a relatively recent study shows. After five years, 84% of supplement users were dementia-free compared to just 68% of non-users in a study of over 12,000 people. Vitamin D reduced dementia risk by 33% in adults with mild cognitive impairment or APOE e4, a key genetic risk factor for neurodegenerative diseases. And while vitamin D reduced dementia risk across the board, some groups benefitted more. Women, adults with normal cognition, APOE e4 non-carriers, and those without depression saw the greatest brain-protective effects from vitamin D supplementation. Vitamin D’s brain-protective effects may stem from its unique role as a steroid hormone, structurally akin to estrogen and cortisol. It regulates thousands of genes, many of which govern critical brain processes—an effect consistent with findings from randomized controlled trials showing improvements in cognitive function and IQ scores in older adults. PMID: 36874594

Polybio is supporting several trials of potential #LongCovid treatments. Working with @PutrinoLab & @CoRESinai, Polybio President Dr. Amy Proal is spearheading an investigation of repurposed HIV antivirals Truvada & Maraviroc for treatment of LC, targeting viral reservoirs

Newsday: 'Stony Brook study: Long COVID risk increases with multiple infections' "Long COVID is now the threat," said Dr. Reynold A. Panettiere, Jr., vice chancellor at the Rutgers Institute for Translational Medicine and Science newsday.com/news/health/lo…

New US research Incidence & Prevalence of Post‑COVID‑19 Myalgic Encephalomyelitis:A Report from the Observational RECOVER‑Adult Study link.springer.com/article/10.100… "ME/CFS is a diagnosable sequela that develops at an increased rate following SARS-CoV-2 infection" #MEcfs #LongCovid

@MattPRD @yesnoerror @pmarca @snewmanpv Now this seems like a great use case for both AI and Crypto. Rooting for this!

I started @yesnoerror and $YNE because I saw @pmarca @snewmanpv and @emollick discussing how AI is now good enough to find errors in research papers. So let's go use AI to find all the errors in all research papers? This should totally exist??? So I built it. And it just took off instantly. Mega viral right out the gate. Millions of views, 10k+ token holders, the most viral thing I've ever been involved in. And I dove headfirst into it. What an incredible mission and moment, how could you not? When the world picks you for a mission like this you accept. It's rare that you get to work on something that genuinely can change the world, and this is one of those projects. We've already found errors in over 100 papers, and soon this number is going to go way WAY up. I imagine finding errors isn't the end of this either, I get the sense that it's just the beginning. And it's so interesting, I don't have a background in research or academia, I didn't go to college (I moved to Silicon Valley to join a startup at 19 back in 2007), I just thought this was a really important idea and I knew how to design (and continue to design) and code the AI agentic system that can do this at scale (this I have more experience than 99.99% of people). As a result I have been on a non-stop crash course learning about everything there is to know about researchers, research papers, and the entire process and system behind them. This is all new to me. Turns out a lot of the academic and research system doesn't make any sense at all! And I feel like I'm only beginning to scratch the surface. Incentives are often all wrong, researchers are doing things they don't want to do in order to get funding, journals and other organizations are profiting off of gatekeeping hard work from often times publicly funded research, the list goes on and on. Not only do we need to go find all of the errors in all research ever published, which we are working on, but academia as a whole needs to be completely disrupted. I know how we are tackling the first problem, we've already started, but I feel there may be something we need to do to impact the second one. @yesnoerror may have snapped into existence in an instance, but we're striving for impact that could last forever. I'm saying this out loud, not because we have accomplished this yet, not to make a promise, but because I am manifesting it. This is the goal. If you are involved in academia, if you are at a top university, if you are on the inside of this right now, and you don't think the system is correct, please DM me and tell me the problems we need to fix, tell me what makes you MAD. If you know someone in academia, or who matches the criteria above, tag them here. Spread the word. We're going after this. I don't know who else is? I don't know everything yet, but one thing I promise you is I learn very fast, our team learns very fast, and we know how to build. Let's go.

A healthy man wants a thousand things, a sick man only wants one. #LongCovid

@yesnoerror @bioprotocol @longcovidlabs This is great. Might I suggest scraping papers from this excellent list #gid=0" target="_blank" rel="nofollow noopener">docs.google.com/spreadsheets/d…

OFFICIAL ANNOUNCEMENT: @yesnoerror is joining forces with @BIOProtocol & @LongCovidLabs to help accelerate Long COVID research. For the first time ever, the @yesnoerror AI agent will not only be looking for errors in papers, but will also be analyzing these research papers for information and insights in order to assist researchers in finding treatments for the 100M+ Long COVID patients in the world. This marks an important expansion beyond just error processing. Leveraging our unique AI agent framework, @yesnoerror will be doing research of its own. We are excited about the potential of this type of initiative and are exploring it as a future use case that could be replicated in other areas. The focus of this @yesnoerror research includes: • Reading and analyzing every research paper related to COVID and Long COVID • Identifying errors in Long COVID studies • Discovering trends and common findings across research • Try to identify potential drug targets for treating Long COVID, by looking at compounds treating acute COVID-19 infections that can be re-purposed for Long COVID • Making research data on Long COVID more accessible All of this will be shared publicly as the research is processed, available to anyone in the world who may find it useful. More information will be made available as we roll this out. We continue to focus on initiatives that are possible with today's AI capabilities. Thank you for your support; we are looking forward to sharing more as we build out this system. As AI improves, and as we process more data, the impact potential of @yesnoerror will only grow. Onwards. 👍👎🚫 $YNE

@longcovidlabs Can’t thank you guys enough for this initiative 🙌🏼

We truly appreciate all of your support so far, and look forward to doing everything we can to end this nightmare! 🙏 #longcovid

@longcovidlabs @CatchTheBaby @Stanford @CatchTheBaby my heart goes out to your daughter as a fellow young long covid patient. It’s hard to reconcile with the feeling of lost time when you are supposed to be in the prime of your life. Hope she feels better soon!

In this clip from Friday’s space, LCL cofounder Dr. Ruth Ann Crystal aka @CatchTheBaby discusses her experience as the mother of a severe LC patient, and her vision for Long COVID Labs. As a @Stanford clinical faculty, entrepreneur, and licensed OB/GYN, Dr. Crystal has seen a keen understanding of the limits of the traditional medical model when it comes to treating Long Covid. Like millions of LC patients all over the world, she and her family have been left to experiment with treatments on their own in the lack of concrete medical help for her daughter. Through their own research and communicating with other patients, they’ve managed to find a few interventions which have provided some relief to her daughter - but it’s clear more is needed. She explains, “It’s really hard to watch someone who’s so vibrant and young and doing so many things and now being bedridden… It’s really hard to watch.” Dr. Crystal was moved to work with @rd108 to found LCL because she realized the unique opportunity of a DAO. Her words are: “When I talked with Rohan about the ability to fund research in a different way, in a faster way, that doesn’t have to work with the administration of things like the NIH… we can move much faster, it really appealed to me.” Dr. Crystal noted that the NIH had spent a billion dollars on mostly observation studies, and hadn’t focused on actual treatments. She says, “There are lots of medications that are already available, that could be used in different ways, and we really need good studies on those. “I’m really excited about this project because I really think patients should be involved and have a say in what they want to see happen, as far as research goes, and I think that with their input we can be a lot more successful in finding treatments.” 1/

How easily doctors say things to you or write stuff in your file that isn’t true and full of bias. An hour later, they’ve forgotten all about it, while it haunts you and affects future care for the rest of your life. #MedicalGaslighting

The #COVID pandemic, took more than 20 million lives, cost $16 trillion, and pushed some 130 million people into poverty. And it’s not over: Figures from October 2024 showed at least 1000 people died from #COVID19 each week, 75% of them in the U.S. science.org/content/articl…

⚠️Over-the-counter protein powders may contain disturbing levels of lead and cadmium, with the highest amounts found in plant-based, organic and chocolate-flavored products, according to a new investigation.

⚠️ BREAKING: Mysterious illness kills another in Rajouri Village, India 🇮🇳 Victims Display Symptoms of Fever, Vomiting, Sweating, Dehydration, and Loss of Consciousness as Cause Remains Unknown.

Thinking “these people are just tired and can’t exert themselves” is one of the primary reason ME/CFS research las lead nowhere for decades. If someone were to sit down and really analyze patients symptoms in agonizing detail, they would learn SO much.

Deeply deficient system Medicine is great at saving lives with surgeries, antibiotics and other emergency-type tools But it is ignorant around healing processes required to sustain optimal health We need a proper Science of Healing and a vehicle to deploy the resulting insights to touch and improve lives x.com/newstart_2024/…

Publications in the past week built substantially on our knowledge of the brain's waste disposal system—glymphatics—and the implications on sleep and brain aging. Featuring exceptional work by @NedergaardLab @MaiNedergaard and @jonykipnis Open-access; link below