Sam Barritt

UVM, partnering with @biolabs, will join an elite group of universities which currently house on-campus incubators, with the launch of a startup incubator for life science research at UVM’s Colchester facility. ⬇️ uvm.edu/news/ovpr/univ…

@SarahPerlee @whitefishlab Congrats, Sarah!!

Thanks to everyone who made this PhD possible! So grateful for my amazing mentor @whitefishlab, committee members, and the entire White lab for all their support these past 5 years! #PhDone

We think this one is groundbreaking: Do you wonder how #SGLT2 inhibitors protect from heart failure? We show that #empagliflozen directly activates PANK1, rate-limiting for CoA synthesis, in human hearts. You read it here first! biorxiv.org/content/10.110…

My first author paper from my thesis work has been uploaded to BioRxiv! We identified Mecr as important for T cell fitness in in vivo CRISPR screens. I have further worked with Mecr and am the first to show it regulates T cell function and metabolism. biorxiv.org/content/10.110…

New study from our lab and Hans Widlund in @CellReports mapping the metabolic routes of the sulfur amino acid cysteine establishing melanoma epigenetic states maintained by lysosome function, conferring resistance to ferroptosis and metastasis shorturl.at/29erU

New preprint from the lab is online! The product of a stellar collaboration with @Muir_Lab, we explore a chemically defined physiologic media formulation based of the metabolite of tumor interstitial fluid (TIF, or “tumor juice”) and its effects on T cell function! A brief 🧵1/

FOR THE LOVE OF PURINES: We are truly excited to share our latest work @CellPressNews on mapping the routes of purine nucleotide synthesis in vivo-De novo and Salvage Purine Synthesis Pathways Across Tissues and Tumors.cell.com/cell/fulltext/…

*New paper alert* I’m happy to share our latest study, out this week in @NatureComms. Led by former postdoc Nate Ward (who now leads his own lab at @MoffittNews), we asked how mitochondria cope with cystine starvation. nature.com/articles/s4146…

Updated preprint up - direct supplementation with the metabolic cofactor Coenzyme A reverses macrophage immunosuppression + promotes pro-inflammatory & anti-microbial macrophage phenotypes via positive influence on CoA-dependent glucose metabolism (1/x) biorxiv.org/content/10.110…

@eclien Congrats Evan!

Happy to share the first preprint from the lab! We describe how extracellular lipid availability regulates a polyunsaturated fatty acid trafficking pathway in cancer cells that influences ferroptosis sensitivity. Check it out! 👇 biorxiv.org/content/10.110…

We are delighted to share the #tyrosine @KinaseLibrary, now in @Nature: nature.com/articles/s4158… Tyrosine predictions and enrichment analysis are now available: kinase-library.phosphosite.org #TheKinaseLibrary #KL #part2 🧵 1/9

Genetically encoding negatively charged lysine PTMs succinylation/glutarylation and studying their funcional roles! Great team effort by first authors @ML_Jokisch and @Maria_Weyh! Congrats @Maria_Weyh @ML_Jokisch @MaxFottner and Anh! 🥳🤩🙌👨‍🔬🧑‍🔬 @klanglab nature.com/articles/s4155…

Excited to share our latest work revealing the requirements of pyrimidine nucleotides in the control of glucose oxidation and lipogenesis published in @ScienceMagazine. Huge congratulations to co-first authors Umakant Sahu and @VillaElodie! science.org/doi/10.1126/sc…

A second-generation degrader of the enzyme AKT—a key supporter of cancer cell proliferation and survival—can deplete AKT and halts breast cancer cell growth, especially in cells with basal JNK kinase activity. @alex_toker @BIDMChealth scim.ag/6a1

Excited to share our new paper out in @PNASNews pnas.org/doi/10.1073/pn… on cysteine susceptibility in #glioma. This was a long effort over years with @CantleyLab @Lnpalma @isaiah_yim Nayah Bullen @barnettd37 @JanKrumsiek @ElementoLab among others @WCMCNeurology @WCM_MeyerCancer

Thrilled to share a new lab preprint spearheaded by superstar postdoc @ApoorvaUboveja in collaboration with @mzspectrum! We discovered something totally unexpected – aKG is important for histone acetylation! biorxiv.org/content/10.110…

@KanarekNaama @KanarekLab @amaynard * @amaynard_

@KanarekNaama @KanarekLab Congrats @amaynard and Naama!! I loved watching this story progress in our monthly "vita-meeting" ❤️

***New Paper***** @KanarekLab: Is this early, aberrant erythroid differentiation induced by folate depletion part of a molecular mechanism of nutritional anemia? check it out - Out today in Science Advances science.org/doi/10.1126/sc…