Simon Breidert

"WASF3 disrupts mitochondrial respiration and may mediate exercise intolerance in myalgic encephalomyelitis/chronic fatigue syndrome" pnas.org/doi/10.1073/pn… Induction of ER stress could play a role in several diseases that include fatigue. @MEcfsTogether @dg_mecfs #MECFS

Great and easy to understand post by @DrRuscioDC on gut dysbiosis and neuroinflammation. drruscio.com/neuroinflammat… I would like to add that fasting and caloric restriction is also effective for dampening inflammation. cell.com/cell/fulltext/…

@CosimoMelcangi mdpi.com/2218-273X/12/1…

3.) Interstingly, a recent study by @CosimoMelcangi found inflammation in the gut of rats after 1 month after withdrawal of finasteride (increase of IL-1β and TNF-α). Leaky gut has not been confirmed in these animals - although I personally find it likely happens in PFS.

1.) Interesting article on the possible cause of post-exercises malaise in ME/CFS healthrising.org/blog/2023/07/1… @dg_mecfs @MECFS_Freiburg @MECFS_Bayern Interstingly, many Post-Finasteride Syndrome patients also report Post-exercises malaise...

@anmol462791 It's my personal opinion. But I think yes, neuroinflammation, might take place in PSSD with downstream consequences on SRD5A2. But everything here - even for ME/CFS should be taken with a grain of salt.

@SimonBreidert Could this be same applied to PSSD I have insane fatigue brain fog and physical tightness in my head.Definitely feels like some kind of inflammation

@iatrogenic_harm - Interaction with ACE2 - changes of sex hormones or LH I personally can think of that withdrawal of these medications could cause inflammation in certain organs (gut lining, reproductive system, brain) with inflammation leading to epigenetics changes.

@SimonBreidert Really need to keep this thread going. Do we know where ADs and fin (& accutane) overlap? Gut for sure. Any evidence of ADs being androgen blockers, or depleting T? Do they hit similar CYP enzymes? I think there’s something to CYP2C9 but I can’t get anyone to look into it.

We see that often in PFS, PSSD and PAS that re-exposure or cross-exposure of finasteride, SSRIs or isotretinoine even after many years of pause can lead to a sudden onset of these diseases - after just a single pill. Big question: Why?

@PSSDSimon @FinasterideInfo I think there might be a trap looking to closely on the main pharmacological actions of SSRIs. There might be thousands of other things that SSRIs can do. I think it's important to look left & right which other compounds (fin, iso) can cause similar symptoms & find commonalities

CW: Male sexual dysfunction New: In search of medical tests for genital numbness finasterideinfo.org/tests-for-geni… #finasteride #dutasteride #sawpalmetto #sexmed

@JuhanaSakari @FinasterideInfo @Max94Cold

5.) Note that some PFS patients report to have a window of improvement after use of antibiotics or inuspheresis before usually relapsing. The bacteria could theoretically also cause autoimmune antibodies when getting in contact with the immune cells in the blood.

@anmol462791 @s4m4rn0ld @Denis_protocol @NoahRyanCo I haven't seen much hypothyroidism yet. It's also pretty common in the general population. Would love to see numbers from both groups

@SimonBreidert @s4m4rn0ld @Denis_protocol @NoahRyanCo I know at least 5 people who took finasteride 4 of them took over 6 months to recover 2 of them now have hypothyroidism because of fin and one of them still has pfs it’s been over 2 years

Pros of Taking DHT blockers: - Maybe save your hairline Cons: - Penile Shrinkage - Low Libido - Erective Dysfunction - Insomnia - Memory Loss - Flatlined androgens - Anhedonia They forget to mention that these side effects can continue after you get off the drug Over 300 people have killed themselves as a result of persistent side effects from Finasteride Look up some forum posts on Post-Finasteride Syndrome (PFS) if you're thinking about trying it

@SadxLady @Leona_Moore95 @ROSIE_PSSD True. But discussion should be 80% about research and 20% about what to try. Not the other way around. Otherwise these diseases might never get fixed.

@SimonBreidert @Leona_Moore95 @ROSIE_PSSD Kinda hard not to when you’re desperate for recovery.

What research tool is the best for getting the best understanding of a the pathomechanism of a disease?

@ROSIE_PSSD @Leona_Moore95 At least a month I would suggest

@SimonBreidert @Leona_Moore95 How much time?

@Leona_Moore95 @ROSIE_PSSD In my opinion the right question. I would say it needs a comparable control group with similar age and lifestyle. Problem is that many in the PFS and PSSD communities are popping supplements and hormones like smarties. Ideally they pause them some time before such a study

@ROSIE_PSSD @SimonBreidert Sounds interesting. But in case of #PSSD and #PFS, how to say which changes come from the disease and which from other influences (even sports, sun etc. can induce epigenetic changes)? We are living in 2023, I don't get why nobody has investigated genital sensitivity yet.

@SirCrypto19 @HLcure2020 @Hairtransplant_ @AlopeciaNoMore @ddg_derma @DermatologyNews @HairLossInWomen @HairlossUK @Merck @AmyPearlman1 @CatherineSNamMD @stopharmingus When that will be treatable depends mainly on the efforts of the patient communitites.

@SimonBreidert @HLcure2020 @Hairtransplant_ @AlopeciaNoMore @ddg_derma @DermatologyNews @HairLossInWomen @HairlossUK @Merck @AmyPearlman1 @CatherineSNamMD @stopharmingus Any update on how we can treat it? I cant go on like this?

@lifeanalytics @cherylbenson Maybe neuroinflammation as initial cause.

@cherylbenson Of course, I am speaking regarding my case here. However, there are some really interesting associations. I had no idea about this but a head trauma can also result to liver injury : ncbi.nlm.nih.gov/pmc/articles/P…

1/ This is a 🧵 for being in remission from #MECFS since 2015. Below, is the email I sent to selected #MECFS researchers (Dec. 2015) which I would like to provide as evidence, as this hypothesis is unpublished (Some parts omitted including recipients and specific regimen steps).