FRSimonetti 🦋

Epstein-Barr virus–mediated B cell reprogramming may initiate systemic lupus erythematosus science.org/doi/10.1126/sc… Preview @GorochovG science.org/doi/10.1126/sc… @ScienceTM @StanfordMed @younis_sh1

Viral vectors displaying peptide-MHC are versatile tools for activating and reprogramming antitumor CD8 T cells directly in vivo @ScienceAdvances @MEBirnbaum @MITdeptofBE @kochinstitute @ragoninstitute science.org/doi/10.1126/sc…

B lymphocytes that enter the germinal center late preferentially differentiate into memory cells that recognize subdominant epitopes biorxiv.org/content/10.110… #biorxiv_immuno

"I watched my advisor publish 21 papers in 1 year. Meanwhile, I spent 8 months on a single study that might never see daylight. I felt like I was failing at academia." A PhD friend told me yesterday ⤴️ Then she shared what changed her perspective completely. Those 21 papers were strategic collaborations solving critical problems across multiple fields. Her single study? That was preventing outbreaks in rural communities! She realized she was comparing apples to oranges. This and other conversations with my PhD friends taught me something important about research careers: 𝗧𝗵𝗲𝗿𝗲 𝗮𝗿𝗲 𝗺𝘂𝗹𝘁𝗶𝗽𝗹𝗲 𝗽𝗮𝘁𝗵𝘀 𝘁𝗼 𝗶𝗺𝗽𝗮𝗰𝘁: → The deep-dive specialist (months/years on one breakthrough) → The strategic collaborator (connecting dots across projects) → The methodology expert (enabling others' discoveries) → The translator (making research accessible and actionable) Quality research isn't about doing less work. It's about doing purposeful work ⤴️ whether that's deep solo research or strategic collaboration. --------------------- 𝗥𝗲𝗹𝗮𝘁𝗮𝗯𝗹𝗲? 🔄 Retweet (& like) Follow @RaziaAliani to get more useful Research content in your feed. Get FREE exclusive tips on using AI in research: 🔗 link in bio

Out now in @NEJM. Sixteen confirmed human infections with A/#H5N1 between 2023–2024. Six deaths. Most in children. All had contact with sick or dead poultry. On paper, it’s another #flu update. In reality, it’s evolution reminding us it never clocks out. nejm.org/doi/full/10.10…

Congrats to Broad Clinical Labs, Roche and Boston Children's Hospital for making a Guinness record for fastest genome sequencing! They were able to sequence and analyse the whole genome in <4 hrs, surpassing the previous benchmark of 5 hrs and 2 mins. A NEJM paper reports application of this rapid workflow in seven NICU patients that returns genetic diagnosis in < 8 hrs. Amazing! News: broadclinicallabs.org/broad-clinical… NEJM paper: nejm.org/doi/full/10.10…

Most blood proteomics analyses of human disease focus on a single disease endpoint missing assessment of specificity. This analysis of 8,262 individuals across 59 diseases offers an atlas of Olink proteomic signatures across the disease spectrum.

The seminal paper of Shimon Sakaguchi published in 1995 @J_Immunol where he discovered CD4+ CD25+ cells that actively suppress autoimmunity. It was the first time T regulatory cells appeared in the literature. Not all Nobel Prize winning work need to be in glamorous journals.

One of the best pieces of career advice I got was from this book when I was in grad school: write 500 words a day, five days a week. An attainable daily goal that compounds quickly: 10k words/month. Keep track of your progress, reward yourself each week. Positive feedback loop.

The viral accessory protein Nef promotes HIV-1 infectiousness by counteracting the antiviral properties of host protein IFITM3 @NCIFredOutreach @ag_bhodrolok science.org/doi/10.1126/sc…

Autologous neutralizing antibody resistance shapes the HIV reservoir during uninterrupted ART @jclinicalinvest @HopkinsMedicine 🇺🇸 jci.org/articles/view/… jci.org/articles/view/…

Vaccines work for koalas too.

Thanks for having me @ASHMMedia: amazing conference! I had the best time learning about 🇦🇺's response to HIV and SHR, and of course...hiv cure research! Cherry on top, the cross-track round table flawlessly led by @JillianLau1. Such a rockstar!

Out Now! HIV-1 capsid found guilty of breaking and entering bit.ly/45dY3qp #HIV #HIVResearch #Microbiology

Unlocking longevity through the comparative biology of aging nature.com/articles/s4358…

📢 Milestone publication for AHRI's Centre of Excellence for Spatial Omics Research in Africa: ✅ 1st published spatial transcriptomics analysis of HIV-infected human lymph nodes ✅ 1st data published from our omics platform 🔗 cell.com/cell-reports/f… @TheNdhlovuLab

Thanks for having me, @MidwestDCFAR!