Lucas Philip Sindlev

Huge breakthrough…generation of human sperm from stem cells ! sciencedirect.com/science/articl…

People having heart attacks have far more microplastics in their blood. A recent study found micro- and nanoplastics in 84% of heart attack patients, versus 40% of patients with stable coronary disease and 32% of healthy controls. The plastics were often accompanied by higher inflammation, including IL-6 and TNF-alpha, and were more common in people exposed to higher air pollution and smoking. We still don’t know whether microplastics are contributing to heart attacks, but this association is very alarming to me.

A study suggests Creatine doesn't just build muscle, it may help supercharge the immune system's fight against cancer ow.ly/K1TJ50ZlX1k

People now speak 28% fewer words a day than they did in 2005 That's ~338 fewer words every year, or ~120,000+ fewer words a year, gone

@michaelzlin Michael, thoughts on this allogeneic gene-enhanced HSC-derived DC cancer vaccine approach: #article-metrics-citations" target="_blank" rel="nofollow noopener">mdpi.com/2076-393X/13/1…

cancer is an engineering problem

Old mice regained stronger blood-forming and immune systems after receiving young blood stem cells, and the transplant worked without chemotherapy or radiation. @NatureComms medicalxpress.com/news/2026-07-y…

Perfusing donor human retinas with blood and oxygen meant they continued to respond to light for up to 10 hours after death, marking a significant step towards eye transplants that restore vision #Echobox=1783726088" target="_blank" rel="nofollow noopener">newscientist.com/article/253367…

A 24-hour fast primed the small intestine to recover from radiation, but only when the gut bacterium Akkermansia muciniphila was present. @PNASNews medicalxpress.com/news/2026-07-f…

@bryan_johnson CAR-T?

My plan to cure autoimmune gastritis To our knowledge, no one has ever done this to try and cure an autoimmune disease. Context: In May, I got diagnosed with autoimmune gastritis (AIG). We found it by taking a tissue biopsy of my stomach. My immune cells are confused, causing my stomach to eat itself. AIG stops your body from absorbing nutrients like iron and B12, and can eventually lead to cancer. It likely started decades ago when I was diagnosed with hypothyroidism when 21 years old. The thyroid and stomach are closely linked in your immune system. I feel fortunate that I've been taking such good care of my body for the past five years as my condition would otherwise be much more severe. Millions of people are affected by this disease and are undiagnosed. Standard of care tells you that you can’t do anything about it. That’s old fashioned. Here is how we are going to try and cure it: Step 0: find and diagnose the disease ✅ AIG is rarely caught early because symptoms are subtle. Early warnings are low iron and B12, but when hemoglobin and hematocrit look normal, doctors routinely miss it because there are no obvious signs of anemia. A standard colonoscopy won't find it either, because it only checks the lower digestive tract, not the stomach. It was only through a highly targeted stomach biopsy that we found it. Even biopsies can miss it if they don't sample the exact right spots. Most people with AIG go undiagnosed. Step 1: Map my immune system ✅ Last Thursday, I had a blood draw to isolate and decode 1 million of my immune cells. Think of your immune cells as trillions of soldiers. Each carries a unique key designed to unlock and destroy a specific threat, like a virus or bacteria. A standard blood test allows you to see how many soldiers you have, but not their keys. Sequencing one million individual immune cells allows us to read the exact pattern of the teeth on every single key. This is important for my autoimmune gastritis (AIG) because a specific platoon of rogue soldiers has developed keys that unlock an attack on my stomach lining. Right now, we don’t know who they are. This test will inform us of which soldiers have gone rogue and are attacking me from within. Once we know the soldier and key, we know what therapy path to pursue to shut them down. Step 2: Catch the rogue soldiers I will be getting a second biopsy from my stomach because we need to collect live tissue. We are currently planning out the logistics of getting the sample from my stomach to the lab. We need these live cells because the initial blood tests showed the antibodies, which prove that an attack is happening, but doesn’t show us the actual rogue soldier doing the damage which is a T-cell. The live sample will allow us to match the immune system mapping we did to the live T-cells. Step 3: Build an early warning system To keep an eye on the disease as we work towards a therapy, we’re building an early warning system. I'll have my blood drawn every two weeks and we’ll pair that information with wearable data to look for flare ups. This is important because the attack happens without producing symptoms that I can easily feel. Step 4: Create a “Bryan in a dish” testing model, a miniature of my immune system At the same time, we are taking a massive sample of my immune cells and deep freezing them (cryopreservation) for two reasons: a) we’ll create a living lab: using these cells to replicate my immune environment in a lab dish. This allows us to test experimental drugs and therapies on my actual live cells before putting them into my body. b) it creates a back up plan for me by preserving the raw cellular material needed for targeted rejuvenation therapies in the future. Step 5: Build precision guided therapies to end the attack Once we know who the rogue soldiers are, we will engineer a therapy designed uniquely for them. The trick is only turning off the rogue soldiers while leaving all the other healthy ones functioning as they are. For safety checks, we’ll do two test runs: 1) we’ll run the therapy through a computer model that has my biology to evaluate how my molecules interact. 2) We will take my actual cells that we froze in Step 4 and watch them interact for real. If both are successful, we’ll pursue one of four therapies: a) fix the mistake my cells are making, restoring my immune system's natural off switches b) teach the rogue cells to tolerate my stomach instead of attacking it c) design smart molecules that physically plug into the rogue cells and turn them off d) build soldiers who will track down and eliminate the rogue soldiers causing the damage

Five servings of fruits and vegetables per day may not be enough for heart health benefits. Only 20% of people who meet these guidelines have an estimated flavanol intake of 500 mg/day, a level associated with lower cardiovascular disease risk in randomized controlled studies.

Protection across three Parkinson’s models points to 15-PGDH inhibition as a potential way to slow neurodegeneration, even though one model’s α-synuclein buildup did not change @UHhospitals medicalxpress.com/news/2026-07-p…

Nine gut bacteria were tied to future type 2 diabetes risk up to five years before diagnosis, including an unexpected pattern in Akkermansia muciniphila that may depend on fiber intake. @CellRepMed medicalxpress.com/news/2026-07-g…

Four injections over six weeks sharply improved a rare autoimmune neuropathy in two patients, with pathogenic IgM antibodies no longer detectable after a short time. @NatureComms medicalxpress.com/news/2026-07-r…

What comes first — the constipation or the chronic disease? Everybody poops, but how often people go could reveal a lot about their long-term health, new research suggests. nbcnews.com/health/health-…

Killer T cells were still present in breast tissue 10 years after pregnancy, a long-lived immune shift that may help explain childbirth’s protection against breast cancer. @petermaccc @natimmunol medicalxpress.com/news/2026-07-p…

Lifetime Estrogen Exposure Shields Women from Brain Atrophy ow.ly/714r50Zgaep

20 yrs of research says protein restriction extends lifespan across a wide variety of systems totally ignored by influencers doing proteinmaxxing

Blocking a small region of TDP-43 protected ALS-damaged nerve cells, and an experimental drug extended median survival in mice by about a week while crossing into the brain. @NatureAging medicalxpress.com/news/2026-07-e…

A form of fibre that boosts the release of the hunger-reducing hormone GLP-1 has been approved as safe by a European regulator, and could be added to foods within a year #Echobox=1783013681" target="_blank" rel="nofollow noopener">newscientist.com/article/253233…

Glucosamine supplements may speed memory loss from Alzheimer’s, new research shows theconversation.com/glucosamine-su…