David Solecki (pronounced so_lets_ki 😉)

Thrilled we finished this 8 yr study w/@NeuroCellPress Wonder what oxygen, blood vessels, Hif1 has to do with cell polarity & neuron migration? Genetics, gaussian & lattice light-sheet crack the case! Cerebellar blood vessels in cyan #cellfie #Science url:cell.com/neuron/fulltex…

Post-graduation jaunt through Santa Fe country. Beautiful enough to make you forget the altitude for a minute. Rattler skin reminder of who really runs the joint 😳

@AschleighJ Definitely but not forever

@So_lets_kiLab70 would you live there if you could live anywhere ?

💥 🚀 New preprint! 🎉🥳 How do hundreds of organelles organize themselves into near-perfect patterns inside a cell, without a blueprint? We dive deep into how basal bodies (BBs) self-organize in MCCs - and how actin actively tunes their dynamics into order 🍪 🧵👇 (1/17)

Celebrating K1 graduating from college 🎉🥳👏🎊🙌🍾

@LiorKir @FedEx That’s next 😉

@So_lets_kiLab70 @FedEx Dendritic spines, axon initial segment, Renvier nodes (:

Mind-blowing cell action alert! Watching vesicle cargo lanes light up like a @FedEx highway in real-time under the #microscope. Who knew that home-brewed phosphatidic acid live cell imaging probe would look so stunning in human fibroblasts? Which organelle do you think its labeling? Drop your guess below! Too late for #FluorescenceFriday but just in time for #MicroscopyMonday #scicomm #sciart #Science

@lreymond2 @FedEx Bingo 🍻

@So_lets_kiLab70 @FedEx plasma membrane and all the internal vesicles that come from membrane recycling.

@Servinlurks @FedEx Could be 🤔

@So_lets_kiLab70 @FedEx Lysosomes.

@HJRBio @HaoYin20 @FedEx Good idea 🤔

@So_lets_kiLab70 @HaoYin20 @FedEx invadopodia / podosome like

@BrankoBrodaric @FedEx Maybe 🤔

@So_lets_kiLab70 @FedEx Mitohondria?

Turns out some virus's get stuck in late endosomes under high membrane tension! Making them unable to infect cells! Congrats to the Tklab Virus Team for our paper @PNASNews. Live 3D LLSM imaging + single cell infection assay! @harvardmed @BostonChildrens pnas.org/doi/10.1073/pn…

We have developed a cysteine-free, highly thermostable tagging system, UTag, that enables single-mRNA translation tracking in live cells. You may wonder how different tagging systems affect translation kinetics—we addressed this by performing a systematic comparison.

📣 Preprint!! Hugely excited for this new direction, an ongoing collaboration with the talented labs of Zoe McElligott and Gina Leinninger. From the McElligott lab - Biased NTSR1 signaling regulates the extended amygdala and suppresses motivated feeding. 🐭 🍩 Check it out 👇

@PDA_PhD It’s better if the solution is blue though lol

Nothing brings a lab together like a 10L volumetric flask being used.

Somite Semaphorin 3A- Endothelial Neuropilin 1 cascade restricts developmental Angiogenesis in Zebrafish Ectopic intersomitic vessel sprouting in mosaic nrp1a/b MO🐟 or nrp1a/b KO🐟 ⏫EC mitosis ⏬EC migration from dorsal aorta/posterior cardinal vein sFlt1-independent Sema3aa/ab more enriched in ventral than in dorsal somites (24-48 hpf) SEMA3A-NRP1▶️EC cell body shrinkage + CD31 loss #Angiogenesis 2026 link.springer.com/article/10.100…

@PhDShaiOvadia @HaoYin20 We use defined reader domains to target a fluorescent proteins to classes of nucleosomes

@So_lets_kiLab70 @HaoYin20 Super cool! How does it works? What do you tag?

Hey y’all 👋 I need a little repost magic. 🔥 The Solecki lab is recruiting MULTIPLE postdocs for a chromatin imaging project at St. Jude. This work sits at the intersection of live-cell imaging, neuronal cell biology, chromatin regulation, and quantitative image analysis — and the eye-popping video below shows exactly why it’s so exciting. This may be for you if you are: • A neurobiologist who wants to become DANGEROUS in cell biology 🧠 • A chromatin biologist who wants to ditch endpoint molecular biology and actually watch nuclear states unfold in living cells 🧬 • An imaging scientist or biophysicist who wants to get messy in real cells, not idealized samples 🔬 A quantitative mindset is required. Prior experience in every area is not. If you ever imagined touring the nucleus like nuclear render and our Pol II biosensor below… reach out because WE can do it. Tag a scientist who needs to see this + RT to help us find them! 🚀 Let’s make chromatin biology history.