Pablo Munoz

¨Fui a los bosques porque quería vivir deliberadamente, de frente sólo a los hechos esenciales de la vida...¨

Are you checking out all the ‘heading’ of the ball in the World Cup? What happens to p-tau after a header? What is p-tau217? p-tau217 is a blood biomarker linked to the tau protein, which plays an important role in brain cells. It has attracted attention because it can reflect brain injury and is also being studied in neurodegenerative diseases such as Alzheimer's disease. Hoppen and colleagues describe in a new paper in JAMA Neurology how heading a soccer ball during real-world amateur matches was associated w/ short-term increases in blood biomarkers linked to neural injury. Key points: - Amateur soccer players who headed the ball showed greater immediate increases in the blood biomarker S100B compared to players who did not head the ball. - More headers, and especially high-impact headers, were associated w/ greater increases in both p-tau217 and S100B, suggesting a dose-response relationship. - These biomarker elevations returned to baseline within 24 to 48 hours, however the long-term implications remain unknown. My take: This is an important study because it moves the discussion beyond speculation. The investigators carefully accounted for the effects of exercise itself and still observed measurable changes in blood biomarkers after real-world soccer heading. That does not mean that every header causes permanent brain damage or that soccer is unsafe. It does mean that repetitive heading leaves a measurable biological fingerprint that deserves further study. The biggest unanswered question is whether these temporary changes accumulate over years and contribute to later neurodegeneration. We simply do not know yet. Studies like this help us ask better questions, identify who may be at greatest risk, and hopefully develop smarter strategies that preserve both the joy of the game and long-term brain health. Here are 5 points that resonated w/ me: 1- Repetitive heading appears capable of producing measurable short-term biological changes in the brain, even during amateur competition. 2- The number and force of headers matter. This study supports the idea that cumulative exposure is important. 3- Blood biomarkers such as p-tau217 may become useful tools for studying brain health in athletes, though they are not ready for routine clinical decision making. 4- Temporary normalization of a blood test does not necessarily mean the brain has completely recovered. More research is needed to understand repeated exposures. 5- The future should focus on making sports safer through better science, smarter coaching, improved techniques and thoughtful policies that protect athletes while preserving the many benefits of participation. cutt.ly/4yecT3wP

Scientists isolate a bacteriophage that switches off a key virulence mechanism in adherent #Ecoli that drive Crohn’s disease, and can attenuate colitis in mice and augment the efficacy of low doses of budesonide. @ScienceTM scim.ag/4aOAd8l

New research examined the evolutionary history of #Parkinsons-associated LRRK2 & PRKN in primates & human populations, finding evidence of positive selection on both genes; LRRK2 G2019S rose in neolithic era due to ancient infectious pressures (Salmonella) nature.com/articles/s4152…

Physicists say they have successfully demonstrated via high-resolution simulations that a DNA molecule can in principle behave like an Archimedes screw in nanoscale. Learn more: scim.ag/3TerI0d

Yo no me lo perdería, y a 1,5 € menos

Striatal neuron dysfunction in C9ORF72-FTD/ALS is driven by AIS and potassium channel dysregulation sciencedirect.com/science/articl…

吉田さちねさん @sachine_yoshidaの背中を撫でて寝かせる研究が各所で紹介されていますが、実際に眠る動画です。 　撫でて寝るようになるには母親からの養育経験が必要です。人工哺育でも体のサイズは遅れなく育ちますが、撫でても眠るようになりません

Exigir grado de Doctor/a, publicaciones y experiencia en investigación para ofrecer $500.000 brutos no es una oportunidad, es precarización de l@s investigador@s en ciencia. Así no se fortalece la investigación en Chile.

Therapeutic targeting of the conserved region within the low-complexity domain of TDP-43 is neuroprotective and extends survival in amyotrophic lateral sclerosis mice nature.com/articles/s4358…

c-MYC is an aggregation-prone, amyloidogenic protein: biorxiv.org/content/10.648…

Ñuñoínos descubren la limonada:

For promoting evidence-based patient care, I receive countless hateful messages daily. I receive death threats. I’ve dealt with frivolous complaints. I’ve been called the "face of evil." I’m lied about and constantly harassed. I’m also not alone.😊✌️ nature.com/articles/d4158…

Y bueno como queremos que se valore la ciencia y al académico que se dedica a ella cuando la @UdeAysen valora el sueldo de un postdoc en 500.000 brutos???? Lo encuentro de vergüenza ajena…

And this is why men should get the HPV vaccine too

Total Eclipse of the Heart en versión de Raffaella Carrà

A 10.5 day old mouse embryo, whole mount immunofluorescence, neurofilament (green 💚) and TFAP2a (red ❤️) 📸 Image credit: Riley McMahon (Children's Medical Research Institute) #FluorescenceFriday #DevelopmentalBiology #Immunofluorescence #Microscopy #ScienceArt✨ 🧬

Delivery of an in vivo–selected AAV into the glymphatics achieves broad transduction of human glial cells in chimeric mice @NatureBiotech 🇨🇳 nature.com/articles/s4158… nature.com/articles/s4158…

Embryo models as experiments in self-organization: The logic of produc... sciencedirect.com/science/articl…

Elephant iPSC !!! And of course they had to suppress p53 since elephants have a lot more of this tumor suppressor than other species. nature.com/articles/s4159…