Subhrajit Banerjee

Updated preprint! Here, we identify an SREBP-dependent fatty acid sensing metabolic switch in Drosophila, enabling dramatic metabolic rewiring within adipose tissue that boosts carbohydrate metabolism in the absence of fat. Read more here: biorxiv.org/content/10.110…

@amtya21 @HenneLab Fantastic! Congratulations Amit and team!

Excited to share new preprint from the lab. Here we show that Pex30 reticulon homology domains generate membrane curvature and increase membrane thickness at ER subdomains that affects LD biogenesis. biorxiv.org/content/10.648…

1/3 Thrilled to see our paper led by Kirandeep Deol is out! We used CRISPR screens to uncover regulators of the ferroptosis suppressor FSP1. key discovery: vitamin B2 metabolism stabilizes FSP1 via FAD, revealing a new way vitamins regulate ferroptosis. nature.com/articles/s4159…

Thrilled to have contributed to this work led by Jesse Garcia Castillo during his PhD at UC Berkeley w/ Michel DuPage. Targeting FSP1 in T cells boosts anti-tumor immunity by relieving Treg suppression, revealing a new immunomodulatory therapeutic axis. science.org/doi/10.1126/sc…

With so many great reviews on LDs already out, do we need another? Sarah @cohenlaboratory & I were approached by @NatRevMCB to organize a review on LD heterogeneity and inter-organelle contacts...topics often in reviews, but not a focus. Fun project! nature.com/articles/s4158…

In the latest issue! Sequencing-free whole-genome spatial transcriptomics at single-molecule resolution dlvr.it/TPXDNq

Thrilled to share our work showing that the bridge lipid transport protein ATG2A transfers diacylglycerol (DAG), and TAG/PA, from the ER to LDs, thereby recruiting DGAT2 to drive local TAG synthesis, promoting LD expansion while protecting ER membranes. nature.com/articles/s4159…

DDHD2, tied to hereditary spastic paraplegia, acts as both a triglyceride lipase and transacylase. While #lipiddroplets don't accumulate in neurons, this raises key questions about fatty acid content and LD dynamics in neurons. 👏 Canals & @airola_lab! pnas.org/doi/10.1073/pn…

Read our latest #research "A heterotrimeric protein complex assembles the metazoan V-ATPase upon dissipation of proton gradients", published with @SpringerNature in @NatureSMB nature.com/articles/s4159…

David Baker, the 2024 #NobelPrize laureate in chemistry, has achieved the seemingly impossible feat of building entirely new kinds of proteins. In recent years, one incredible protein creation after the other has emerged from Baker’s laboratory. They range from new nanomaterials where up to 120 proteins spontaneously link together (see animation) to proteins that function as a type of molecular rotor. Animation: ©Terezia Kovalova/The Royal Swedish Academy of Sciences

New paper in @ScienceMagazine identifying adipogenin as a critical seipin regulator in LD biogenesis. So glad our lab could help a little in this monumental study. Congrats to all authors! science.org/doi/10.1126/sc…

Excited to share our new study out in @NatureCellBio! Led by postdoc @MikeLangePhD, we identify the first #LipidDroplet lipid quality control pathway: LD-localized FSP1 protects stored lipids from oxidative damage and prevents LD-initiated #ferroptosis. nature.com/articles/s4155…

@HijaiShin @pewtrusts @RobertoZoncu @SJMorrison_ Congratulations Regina!!

Thrilled and deeply honored to be named a 2025 Pew Biomedical Scholar! Huge thanks to @pewtrusts for believing in our science and supporting our vision. Grateful to my mentors—@RobertoZoncu, @SJMorrison_ and many more—for their guidance, inspiration, and unwavering support.

Excited to share our new preprint led by Kirandeep Deol! Genetic screens uncover mechanisms regulating FSP1 abundance in cancer. Vitamin B2 metabolism promotes FSP1 stability via FAD synth / binding, further linking nutrient metabolism to #ferroptosis. biorxiv.org/content/10.110…

We are proud to be a founding contributor to lipidinteractome.org, a repository developed by @TheTafesseLab & Schultz lab to increase accessibility to proteomics data from multi-functionalized lipid analogs! Check out the website & preprint: arxiv.org/abs/2507.23101 #lipidtime

If you're tired of AI and stuff...we published CRISPR-based protocols that you can actually use to delete alpha-synuclein (~100% efficiency) or knock it into endogenous locus (~53% eff) in cultured neurons: star-protocols.cell.com/protocols/4339

Dennison and Baldridge @UMichMedScience reveal how the #Golgi-localized Tul1 #ubiquitin ligase complex targets substrates to the #proteasome versus the vacuole in S. cerevisiae. hubs.la/Q03yh31t0 #Biochemistry #ProteinHomeostasis

@HenneLab Thank you Mike!

Exciting new work from the Prinz lab examining a role for BLTP2 lipid transporter in cancer cell biology.

@limcy1_cellbio Thanks Chun-Yan!

@Subhrasparadigm Beautiful work! Congratulations Subhra! 🙌😊

Excited to announce my publication from my research in the Prinz lab in Nature Cell Biology! 🌟 We've uncovered a new pathway regulated by the tube-like lipid transport protein BLTP2, which cancer cells utilize to control their plasma membrane fluidity. nature.com/articles/s4155…

@amtya21 Thanks Amit!

@Subhrasparadigm Congrats Subhra!!