Gut Onc Lab

The Gut Onc Lab podcast now available on Apple Podcasts and Spotify! @GIMedOnc @TimothyJBrownMD @UGrewalMD Spotify- open.spotify.com/show/34O9YdVYy… Apple- podcasts.apple.com/us/podcast/the… Subscribe and tune in! We’re planning to bring many thoughtful discussions to you in forthcoming episodes.

@TheGutOncLab @OncBrothers @ShaalanBeg @NiuSanford Done! Practical questions on common #GIonc issues we face in #community oncology. Looking forward to seeing you all at #ASCO26. Need to collect a full @TheGutOncLab series of selfies @GIMedOnc @TimothyJBrownMD @UGrewalMD

@GIMedOnc @TimothyJBrownMD @UGrewalMD @Onco_Nexus @ASCO Ahhhh… love this! Eagerly look forward to these results and how we can learn/optimize our practice!!

Are you a GI medical oncologist or community hematologist/oncologist routinely seeing patients with GI malignancies?—we’d love to hear from you. Please take 1-2 minutes to answer some simple questions for this survey. redcap.link/5FU

#ASCO26 MSI-H feels like the wild west out there. We have nonoperative management, dual checkpoint inhibitors and everything in between. Key questions remain: How long should we treat for? Is NOM safe? asco.org/abstracts-pres… Observation vs maintenance PD-1 after cCR in dMMR/MSI-H CRC managed with NOM Abstract #3502 Presentation: May 31, 2026, 8:00 AM This multicenter China cohort asks a very practical question: If a patient with dMMR/MSI-H CRC achieves cCR on PD-1 therapy and enters NOM, do they need maintenance PD-1? Quick hits: 📌 318 treated with PD-1 195 achieved cCR 129 analyzed in NOM cohort 🧬NOM Population 58 rectal 61 colon 10 synchronous dual primaries 14 had distant metastases at diagnosis ⏱️ Median PD-1 exposure to cCR 8 cycles in both groups (?cycle length?) 69.8% achieved cCR within 8 cycles 📈 3-year DFS Observation: 96.4% Maintenance: 98.4% p=0.55 🙌 3-year OS Observation: 100% Maintenance: 98.4% p=0.34 🔥 Regrowth was rare ONLY 2 local regrowths with observation No distant metastases ⚠️ Toxicity difference was significant Grade 3 irAEs: 3.0% vs 11.1% One third! My take: if MSI-H CRC achieves cCR on PD-1 and is managed non-operatively, observation looks very reasonable. (And overall this is more evidence that NOM is safe for MSI-H CRC). Maintenance added toxicity without a clear DFS or OS signal. Still a lot we do not know. Almost certainly this depends on patient, disease site, disease burden, and quality of cCR assessment. But this is fascinating data. Honestly, plenary-worthy? @TheGutonclab @UGrewalMD @TimothyJBrownMD @OncoAlert @Onco_Nexus @ASCO @NazliDizman @LauraAlderMD @DVAraujoMD @DrBarbiOnc @LauraEsfeller @FunchainMD @YGaritaonaindia @DrSAHaddad @jgong15 @iandresmeraz @SakditadMD @RamilaShilpakar @RohitBanwar @lungoncdoc

🎬 Nicholas Hornstein, MD, joined us at our home studio for a filming of our studio show Double Blind and podcast Oncology On The Go! Be on the lookout for clips and content! #oncology #crcsm | @GIMedOnc

Thanks for having me @CancerNetwrk ! Excited to come in the footsteps of @BalazsHalmosMD for the second episode of Double Blind! Great timing with #ASCO26 coming up. Stay tuned for more analysis and updates with a focus on GI Oncology! @TheGutOncLab

@GIMedOnc Awesome paper! Great line up of authors!

An amazing team of authors from @TheGutOncLab and @Perlmutter_CC came together to discuss real world doses, toxicity management, and optimizing regimens in GI Oncology. First author Dr. Sabrina Bulancea will be an oncology star, congrats on starting fellowship soon! @OncBrothers

Happy to share our latest pub in Clinical Colorectal Cancer. In this review, we discuss current approaches to optimizing systemic therapy for advanced GI cancers and the need for practical, patient-centered care pathways. @UGrewalMD @GIMedOnc @TimothyJBrownMD @guildsman

Congratulations Sawyer!

Thrilled and honored to be named Junior Chief Fellow for 2026-2027! 🎉 Huge congratulations to my co-fellows: Dr. Rafa Litvin & Dr. Chana Peysin (Senior Chiefs) and Dr. Samatha Ankireddy (Junior Chief) #OncTwitter #MedTwitter #MedX @ClevelandClinic @ccfhemonc @CCF_IMCHIEFS

New paper out now “Optimizing Systemic Therapy in Advanced Gastrointestinal Malignancies: Strategies to Minimize Toxicity and Maximize Tolerability” in Clinical Colorectal Cancer @UGrewalMD @Deebacca @GIMedOnc @guildsman @TheGutOncLab clinical-colorectal-cancer.com/article/S1533-…

Check out this hot off the press publication led by PGY2 Neha Puttagunta @NorthwellHealth, mentored by @GIMedOnc, exploring the prognostic significance and genomic landscape of viral versus non-viral combined hepatocellular–cholangiocarcinoma (cHCC-CCA). link.springer.com/article/10.100…

Yesterday we held our 2nd annual Kicking Colon Cancer’s Butt kickball fundraiser benefiting the @CCAlliance. More teams. More energy. More money raised. In fact, we doubled last year’s total. ⚽💙 Thanks to everyone who came out, played, donated, sponsored, and helped make the day happen. Special thank you to our major sponsors, including @NorthwellHealth, @bmsnews , and @GuardantHealth , for helping support the event. Important to highlight and support an incredible organization in the Colorectal Cancer Alliance, whose work in advocacy, screening, research, and patient support is helping to cure colorectal cancer in our lifetimes. Already looking forward to making it even bigger next year. @TheGutOncLab @Onco_Nexus @OncoAlert

I had never thought this would happen before my first year as faculty came to a close, but here we are. What an honor to have @NCFCancer @lisayentwin come down to Atlanta, GA for this patient and caregiver conference. We had the privilege of hosting 120 patients and caregivers and colleagues from @WinshipAtEmory @UABNews and @VUMCDiscoveries at this hugely successful event. I’m so fortunate to have played a small role in making this happen. Thanks to Lisa, Heather, Kavya and the entire NCF team for your generosity and advocacy- you guys make us all who we are today. @PoHienEar @SethConcorsMD @NANETS1 @CureNETs @TheGutOncLab 🦓 ❤️

@TimothyJBrownMD @TheGutOncLab @Onco_Nexus Looking so official!

Excited to host our first Guest of the Pod @NiuSanford on @TheGutOncLab podcast to discuss organ preservation in upper GI cancers. Available @Onco_Nexus Apple and Spotify oncologynexus.com/podcast/organ-…

🧬Universal germline genetic testing is recommended for all patients with pancreatic cancer, yet a new #OpenAccess study from @UGrewalMD and colleagues suggests many still face barriers to testing access and uptake. Read the study: acsjournals.onlinelibrary.wiley.com/doi/10.1002/cn… @OncoAlert @PanCAN

We had the legendary @NiuSanford on the @TheGutOncLab podcast to talk about non-operative management in upper GI cancers. Great to focus on radiation oncology and highlight an absolutely essential modality. On Apple/Spotify tomorrow, onconexus today. open.spotify.com/show/34O9YdVYy…

On the latest episode of @TheGutOncLab, @NiuSanford joined @GIMedOnc & @TimothyJBrownMD to discuss the dynamics of long-term surveillance after organ preservation in upper GI cancers. They break down how rigorous follow-up, tight multidisciplinary coordination, and smart patient selection make this strategy both safe and sustainable over time. Watch the full episode below: oncologynexus.com/podcast/gut-on… Live on Spotify/Apple Tomorrow!