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Joris
487 posts
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You're confused. Let me explain:
My student @Y_Ryan_Lu worked for years to find a SAFE way to reprogram cells so they'd only RE-GAIN identity, not LOSE it, as Prof Yamanaka showed
We tried innumerable combos to find the solution
Story is @Nature now
nature.com/articles/d4158…
Parmita Mishra@parmita
Yamanaka factors reprogram somatic cells back to pluripotency. Beautiful technology. Nobel Prize. One problem: the epigenetic reset is so thorough that the Horvath methylation clock reads approximately negative 0.7 years. Doesn’t matter if your donor was 21 or 100. You get a fetal cell. This is simultaneously the greatest strength for regenerative medicine and the most fundamental limitation for disease modeling. Diseases accumulate over decades through aging-related epigenetic changes, environmental exposure, and progressive cellular damage. Reprogramming erases exactly the signatures you need. And yet, it might be the best disease model for dementia that humans have created.
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Yes, pharmaceutical HDAC inhibitors like vorinostat (SAHA), romidepsin, and valproic acid are significantly more potent than butyrate. They're FDA-approved for cancer or neurological uses, but carry side effects such as fatigue, GI issues, and blood count changes. Not available OTC for longevity—requires a prescription and medical monitoring. Butyrate via diet/supps remains the practical, low-risk starting point.
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Nothing dramatic like the experimental OSK gene therapy in the Nature paper— that's not achievable with diet/supps alone.
Boosting butyrate via resistant starch (cooled potatoes/bananas) + butyrate supplements/probiotics could:
- Ramp up gut butyrate production, supporting microbiome diversity and reducing inflammation.
- Act as a mild HDAC inhibitor, aiding epigenetic tweaks that lab studies link to better cell reprogramming efficiency (in vitro).
You'll likely notice better digestion, steadier energy, and possibly lower systemic inflammation over weeks. No full cellular reset or lifespan extension guaranteed, but it's a solid, low-risk longevity hack aligned with Sinclair's work. Track how you feel and chat with a doc before high doses.
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@davidasinclair @Y_Ryan_Lu @Nature @sinclairfriends @grok @grok If I take those supplements, and eat cold bananas and potatoes, what will happen?
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@Wasquen @davidasinclair @Y_Ryan_Lu @Nature @sinclairfriends @grok Refined starch and probiotics to boost butyrate production. Butyrate boosts all those factors. Read up on it.
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@grok @Adhd_Hana Do i need prescription for melatonin? So long the lux lamp?
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ADHD가 밤에 말똥말똥하고 아침에 유독 몽롱한 이유가 밝혀짐.. 단순 도파민 부족이 아니라, 만성적으로 뇌가 시차를 겪고있다는 연구결과야! 그래서 자야할 때 못자고 일어나야할 때 안일어나진대
핵심은 뇌의 생체 시계가 일반인보다 몇 시간씩 뒤로 밀려 있다는 거야. 밤 12시가 넘어도 멜라토닌이 안 나와서 뇌가 쌩쌩하고, 반대로 아침엔 코르티솔이 안 나와서 마취된 것처럼 계속 졸린거래. 사회적 시간이랑 우리 뇌의 시간대가 달라서 시차 적응을 못한채로 시달리고 있는 셈인거지..
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Introducing Quality mode on Grok Imagine – powered by our most advanced image generation model.
Quality mode gives you enhanced details, stronger text rendering, and higher levels of creative control.
Now available on web and mobile.
Try it at grok.com/imagine
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Farm client showing me the yield map today.
Can you see where the manure was applied? …
Here’s what’s cool! The manure was applied 20 years ago!
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@levelsio I think this one is okay:
koehlerpaper.com/en/products/Th…
That’s what I am gonna use for my kid
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I don't wanna say but I told you guys
Touching receipts -> BPA enters your bloodstream
High BPA levels in adolescents -> 50% reduction in Testosterone levels
Maddie Evans@EstieMaddie
🧾 BE CAREFUL HANDLING THERMAL RECEIPTS!! 😳 DID YOU KNOW THIS???
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I heard you guys like useful Pretext stuff
Can you keep up?
Vlad@VladArtym
Okay I think I finally found a good use for @_chenglou 's Pretext. A resume builder that always fits on one page with realtime rendering.
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We're introducing laws today to crack down on sneaky hidden fees when you pay.
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