Gut microbiota-derived metabolites as immune modulators in aging and a... sciencedirect.com/science/articl…
Nearly everything you need to know on gut microbiome metabolites, immunity and aging in a single review!
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Dan and Shawn Winer
63 posts
Dan and Shawn Winer
@Winer_Imm_Lab
Immunology, Laboratory Medicine and Pathobiology Lab | UofT/USC/UHN/St Michael's/Buck Institute | Immunometabolism, Mechanoimmunology, Astroimmunology, Aging
Marin County, CA Katılım Mart 2023
256 Takip Edilen137 Takipçiler
Dan and Shawn Winer retweetledi
B cells promote CD4 T cell aging and decline in health-span parameters through intercellular communication and nutrient sensing @SciImmunology @Winer_Imm_Lab @UofT
science.org/doi/10.1126/sc…
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Dan and Shawn Winer retweetledi
🚨 New publication alert! Research from @UHN reveals a mechanism behind why the immune system declines with age.
B cells—best known for producing antibodies—play a critical role in driving the aging of T cells, fighters of infection.
🔗 Read more: uhnresearch.ca/news/aging-and…
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B cells drive CD4 T cell immunosenescence and age-associated health decline | Science Immunology science.org/doi/10.1126/sc…
More than 10years of work from our lab showing that B cells are major players in T cell aging. Thank you to the team!
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Dan and Shawn Winer retweetledi
🚀 Excited to share our new Nature Reviews Immunology paper: “Astroimmunology: the effects of spaceflight and its associated stressors on the immune system.” We explore how space environment impacts impacts immunity, vital for Moon & Mars missions.
doi.org/10.1038/s41577…
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Dan and Shawn Winer retweetledi
Review out in Nature Reviews Immunology: Astroimmunology—how spaceflight reshapes immunity. I’m a co-first author. Co-firsts: Daniel Winer & Huixun Du. Corresponding/senior: Winer, Mason, Choukér & Crucian. @mason_lab doi.org/10.1038/s41577… #Astroimmunology
Nature Rev Immunol@NatRevImmunol
Astroimmunology: the effects of spaceflight and its associated stressors on the immune system bit.ly/3J9Oodi
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Dan and Shawn Winer retweetledi
"Astroimmunology: the effects of spaceflight and its associated stressors on the immune system." Excited for this @Nature Reviews Immunology paper! Summarizes the past few decades of spaceflight and immunology and next steps: nature.com/articles/s4157… bravo @KJangkeun @Marissa_R_Burke from our lab and Winer, Choukér & Crucian
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Dan and Shawn Winer retweetledi
It is my pleasure to share this in-depth investigation of the gut-brain axis. Hope you will enjoy this humble exploration of new hypotheses--a process I truly enjoyed.
Buck Institute@BuckInstitute
Is brain/gut axis a superhighway for immune response to #Alzheimers? Study @CellReports shows immune cells use that route in mouse models. Feeding animals a high fiber diet reduced AD-related frailty. Congrats @Winer_Imm_Lab @pmakhijani16 @JKAndersenBuck buckinstitute.org/news/the-gut-i…
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Dan and Shawn Winer retweetledi
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Dan and Shawn Winer retweetledi
Is brain/gut axis a superhighway for immune response to #Alzheimers? Study @CellReports shows immune cells use that route in mouse models. Feeding animals a high fiber diet reduced AD-related frailty. Congrats @Winer_Imm_Lab @pmakhijani16 @JKAndersenBuck
buckinstitute.org/news/the-gut-i…
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Dan and Shawn Winer retweetledi
📢New Recommended Reading📖
Substrate stiffness dictates unique doxorubicin-induced senescence-associated secretory phenotypes and transcriptomic signatures in human pulmonary fibroblasts Huixun Du & Daniel A. Winer (@Winer_Imm_Lab) et al.
link.springer.com/article/10.100…
#tissuestiffness #doxorubicin #transcriptomics #senescentcells #senescenceassociatedsecretoryphenotype
Buck Institute@BuckInstitute
Many age-related diseases involve fibrosis. Study in @GeroScienceAGE shows mechanical forces shape #cellularsenescence and related secretory phenotypes. Researchers in Winer lab ID’d unique high-stiffness-driven secretory protein profiles link.springer.com/article/10.100…
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doi.org/10.1186/s12979… Great review on the role of antibodies in obesity and aging pathology.
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Substrate Stiffness Dictates Unique Doxorubicin-induced Senescence-associated Secretory Phenotypes and Transcriptomic Signatures in Human Pulmonary Fibroblasts biorxiv.org/content/10.110…
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Dan and Shawn Winer retweetledi
The inflammaging clock strikes IL-11! @ImmunityCP @Winer_Imm_Lab
cell.com/immunity/fullt…
Spotlight on @Nature
nature.com/articles/s4158…
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The inflammaging clock strikes IL-11!: Immunity cell.com/immunity/fullt…
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Dan and Shawn Winer retweetledi
This is our first major paper of the lab showing early life modulation of T1D development, linked to maternal IgA deficiency. Super proud of the work twitterless Erinnand Luisa have done!
Waggoner Lab@LabWaggoner
Maternal humoral factors modulate offspring gut immune homeostasis to mitigate diabetes development @SueYTsai1 doi.org/10.1101/2024.0…
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@dr_makhijani_ @BuckInstitute Slaying Dragons...... and Defying Gravity - literally😀
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Another gorgeous day in Marin county, slaying science dragons with the #dreamteam
@buckinstitute @Winer_Imm_Lab
Check out what we have been upto: buckinstitute.org/lab/winer-lab/
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@MattYousefzadeh @Furman_Lab @AfshinBeheshti @mason_lab @SpaceX @elonmusk @NASA hey Matt, hope all is well. I'll email you but posted that other paper as well which sort of answers your question.
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@Winer_Imm_Lab @Furman_Lab @AfshinBeheshti @mason_lab @SpaceX @elonmusk @NASA Very cool work, congratulations! Any chance you see increased expression of telomerase? Just wondering if that was the cause of the expanded telomeres observed in the NASA Twin Study.
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One of the most detailed analyses of immune system in microgravity and spaceflight ever done. Via AI, we found space nutraceuticals for future space travel. Thanks @Furman_Lab @AfshinBeheshti @mason_lab @SpaceX @elonmusk @NASA #citeas" target="_blank" rel="nofollow noopener">nature.com/articles/s4146…
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Dan and Shawn Winer retweetledi
Papers from our Space Omics and Medical Atlas (SOMA) package, built upon the extraordinary data from the @inspiration4x mission with @SpaceX are now coming online. With more civilian crews going to space, this is truly the opening of the Second Space Age: nature.com/articles/s4158…
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