International Natural Product Sciences Taskforce

The excellent outcome of #INPST-based collaborative work #NaturalProducts #DrugDiscovery By: @_INPST @_atanas_ @univienna @LBG_research @FrancescaGiamp5 @Bio_Lab_UNIVPM @DHPSP @maciejbanach @ilkay_E_ORHAN @BgSciencesBAS @docmmiller @UNI_FIRENZE @NatRevDrugDisc @MedUni_Wien

@_MCRicardo_ Reductionist nutrition failed because humans do not metabolize isolated compounds

“Epigenetic fingerprints link early-onset colon and rectal cancer to pesticide exposure.” Published April 21, 2026, Nature Medicine nature.com/articles/s4159…

Encouraging a move toward precision geromedicine 🔑"Only by embracing heterogeneity as signal rather than noise can aging biology be translated into effective, preventive, and truly personalized medicine." 🔗sciexplor.com/geromedicine/a… Commentary by Luigi Ferrucci, Stefano Donega, @AndreaBMaier, Guido Kroemer | @geromedicine

Effectiveness of exercise snacks on physical function: a systematic reviews with meta-analysis of randomized controlled trials 👉Exercise snacks absolute peak power, max oxygen uptake, the number of sit-to-stand test in the 60-second + reducing body fat. sciencedirect.com/science/articl…

Microbiome-Linked Metabolic Architecture of Accelerated Biological Aging in Humans "These findings support an exploratory, hypothesis-generating framework in which methylamine-related metabolism and chronic inflammatory signaling are associated with biological aging in ASD. Because of the cross-sectional design, these results should be interpreted as associative rather than causal." aginganddisease.org/EN/10.14336/AD…

New urine test for lung 🫁 health? Scientists have developed an injectable nanoprobe that detects therapy-induced cellular senescence and pC- simply by peeing in a cup. The probe releases gold nanoclusters when cut by MMP-7, an enzyme elevated in senescent lung #cancer cells and fibrotic tissue. These tiny clusters pass into urine, where a simple colorimetric assay reveals disease activity. In mouse models, the test tracked chemotherapy-induced senescence, monitored senolytic drug effects, and spotted early #lung fibrosis - noninvasively and longitudinally. nature.com/articles/s4358…

You can flip your biological stress switch in under 30 seconds. It’s called the Physiological Sigh. Do this: 1️⃣ Take a long inhale through your nose. 2️⃣ At the very top, take a second, shorter "top-up" inhale. 3️⃣ Let out a long, slow exhale through your mouth. Why it works: The double inhale re-inflates the tiny air sacs (alveoli) in your lungs. This allows you to offload carbon dioxide more efficiently, which is a signal for your brain to "calm down." A 2023 study in Cell Reports Medicine found that just 5 minutes of daily cyclic sighing improved mood and reduced anxiety more effectively than mindfulness meditation. Try it for 5 minutes a day — or 1 to 3 sighs in the moment when stress spikes. The benefits build over time if you're consistent. Source: Balban, M. Y., et al. (2023). Brief breathwork vs. meditation for mood & arousal. Cell Rep Med, 4(1).

A Multiomics Framework to Unlock the Relationships between Wine, Food, and Gut Health ▶️ This review explores current evidence regarding the impact of moderate wine consumption on human health, w/a focus on its interactions w/gut physiology & metabolism. It provides an innovative framework, leveraging advancements in multiomics to enable research to decipher the understudied interplay between wine’s bioactive compounds, food matrices, gut functions, & health. sciencedirect.com/science/articl… @HealthyFellow @drfherediaz @DrKristieLeong @Mangan150 @DrRPalmquist @_atanas_ @LoriShemek @tatiann69922625 @louisanicola_ @DrGrimaldesJ There is a growing interest in wine and health research across the major physiological systems, including the gastrointestinal tract. (A) Tree map highlighting publication numbers for the search terms “wine AND” [the major physiological system], including the gastrointestinal tract with 105 articles related to microbiota (refer to Supplemental Table 1). (B) An illustration of a trend in publications reporting on wine and the gut compared with wine and the cardiovascular system. Data shown are the number of research articles on PubMed using the search terms “wine AND cardiovascular” and “wine AND gut” between 1957 and 2025. (C) A proposed multiomics framework to decipher molecularly defined 3-way relationships among wine, food, and gut health.

Association of Circulating Vitamin D in Midlife With Increased Tau-PET Burden in Dementia-Free Adults 💊"Low vitamin D in midlife may represent a potentially modifiable target to mitigate the risk of neuroimaging signs of preclinical dementia." neurology.org/doi/10.1212/WN…

Obesity has risen in all countries - but at a faster pace in poorer ones. New global study of 232 million people reveals a dramatic split in the #obesity epidemic: In high-income Western countries, the rise in obesity has plateaued or even begun to reverse, especially among children, with countries like Japan, France, and Denmark stabilizing at low prevalence levels (3–6%). But in most low- and middle-income nations, obesity is accelerating faster than ever, with 2024 velocities hitting record highs across Asia, Africa, Latin America, and the Pacific Islands. The study, analyzing four decades of data from 200 countries, shows that while some wealthier nations have curbed the rise (likely due to food policies, social norms, and health awareness), developing regions are seeing obesity surge - even where prevalence already exceeds wealthy countries. nature.com/articles/s4158…

Early-onset colorectal cancer was linked to epigenetic fingerprints of pesticide exposure.

AI drug prescribing may arrive before safety evidence and legal guardrails catch up.

“Ultraprocessed Food Consumption and Behavioral Outcomes in Canadian Children.” Published March 3, 2026, JAMA Network Open jamanetwork.com/journals/jaman…

@_atanas_ And that's why I am stressed all the time.

@_atanas_ If these results hold up in larger trials, we may be witnessing a turning point in depression treatment. A single-day inhaled psychedelic therapy achieving rapid remission with sustained benefits months later is something psychiatry has been searching for for decades.

📌 Social Media and References: #INPST #DHPSP #CRBIOTECH and #ExplorDHT 🔗linkedin.com/pulse/social-m…

@_atanas_ x.com/clayton_ulm/st…

AlphaFold 3 predicts the structure and interactions of all of life’s molecules "By accurately predicting the structure of proteins, DNA, RNA, ligands and more, and how they interact, we hope it will help to transform our understanding of the biological world and drug discovery." isomorphiclabs.com/articles/alpha…

Longevity expert shares his daily routine for wellness: I’m ‘really intentional’ about applying my research to my life @CNBC with @mkaeberlein🌟 🔗cnbc.com/2026/02/06/lon…

Sleep chart of biological ageing clocks in middle and late life ⚠️ Short (<6 h) & long (>8 h) sleep duration, compared w/a normal sleep duration (6–8 h), are associated w/increased risk of systemic diseases beyond the brain & all-cause mortality, w/evidence from genetic correlations & time-to-incident survival predictions, such as depression & diabetes. ▶️ The findings of this article suggest a U-shaped, multi-omics, & multi-organ relationship between sleep duration & biological clocks of aging, highlighting the potential of sleep optimization to promote healthy aging, reduce disease risk, & extend longevity. nature.com/articles/s4158… @HealthyFellow @Mangan150 @tatiann69922625 Clinical evidence for a systemic involvement of abnormal sleep duration patterns compared w/normal sleep duration.