Aaron Saunders

@mattpocockuk thank you. I have learned them. The suggestion was to spell them out in his materials and videos for first timers.

@mattpocockuk I get a lot out of your work, teaching and skills. AI is democratising software. I am a scientist now a dev with the help of AI. Please spell out the terms: eg. ADR, RFC, PRD, more clearly & often for us coming from other fields. 🙏

/grill-me is my most popular skill ever. I get 5-10 messages a day about how it’s changed people’s workflows for the better But… I’ve stopped using it for code. Here’s the improved version:

@ItsKingSlime You're not going to like it but mine is that you can't be a great singer and a competent thinker. You just can't be both. 😂

Billie Eilish says eating meat is WRONG and people can’t claim to love animals if they eat meat 😳👀

@CosmicSkeptic I think the other work Ricky's story does is point out to the believer of a specific God that their belief is due to the contingency of where they were born. But your point about the difference between zero and one is well taken.

I’m getting a lot of hate for this reel. What do you think? (P.S.: if you say “but we have evidence for dads I believe you have missed the point.)

@NLRG_it There are some fascinating insights in scientific disciplines that go against common wisdom or intuitions. This is one of the exciting things about gaining an expertise. If you think the statement is weird, be curious about it and learn.

scientific american, ladies and gentlemen

Most of coding was never about writing code. AI is just making this more obvious. You no longer need to recall syntax, function structure, boilerplate code, or even API endpoints. That’s the easy part and AI is very good at it. The hard part was never typing. It was always thinking. And it still is.

Still typing on Android? Fix that. Join the Flow waitlist. Win stuff 🚀‍wisprflow.ai/waitlist?AARON…

@0FreeRadical0 @NikoMcCarty the multisub system looks pretty nice. Different run lengths and 96 wells plus markers thistlescientific.co.uk/product/multis…

@NikoMcCarty It's still crazy that we don't have 96w vertical gels to combine with pcr plate setups. Anyone working on it?

It is really remarkable how so many things in biology, which we take completely for granted, were adopted by accident. One example: When scientists run a gel to separate DNA molecules, they usually add ethidium bromide to the agar. Ethidium bromide is a fluorescent dye that locks into the DNA grooves and emits a red-ish color when you shine a UV light on it. It's an easy way to see where DNA ends up in the gel. But the only reason Ethidium Bromide staining even happened is because of a broken centrifuge. In 1972, two Dutch scientists (Cees Aaij and Piet Borst) were trying to separate DNA isolated from mitochondria. They were spinning down the DNA inside of a big centrifuge, and the machine broke. Undeterred, the duo decided to separate their DNA using gels instead. Agarose gel electrophoresis had been used since the 1960s to separate radiolabeled DNA. The DNA molecules were modified to carry a radioactive isotope (usually heavy phosphorus) and then scientists would move them through the gel and use a radiation detector to figure out where the DNA went. This was obviously both tedious and dangerous. The brilliant insight that Aaij and Borst had was, instead, to just add ethidium bromide to the gel so that the DNA would "light up" instead. No radiation needed. The Dutch scientists stopped using their centrifuge entirely and began separating DNA molecules using this new approach instead. Their discovery spread quickly. (The first gels looked like garbage, though!)

@0FreeRadical0 @NikoMcCarty thistlescientific.co.uk/product/multis…

@rshereme To Trump fear equals respect. So these data do not contridict his statement.

Trump’s Approval Rating in Europe First, Trump’s approval rating in Europe is at a historic low - the lowest of any American president on record. Today, he is one of the most hated figures in Europe, second only to Putin. Second, the disapproval is nearly universal (Romania and Kosovo are surprising outliers). Countries that were historically close U.S. allies now view the United States as a potential adversary. Third, the propaganda coming from Trump’s administration claiming that “everyone now respects” the U.S. is exactly that - propaganda and lies. The data show the opposite.

Alexander Fleming's discovery of penicillin is unlikely to have happened in the way he described. It's almost certainly a myth. For decades, scientists and historians have puzzled over inconsistencies in Fleming’s story. The window to Fleming’s lab was rarely (if ever) left open, precisely to prevent the kind of contamination that supposedly led to penicillin’s discovery. Second, the story is strikingly similar to Fleming’s earlier discovery of lysozyme, another antibacterial substance, which also featured lucky contamination from an open window. Third, Fleming claimed to have discovered the historic culture plate on September 3rd, but the first entry in his lab notebook isn’t dated until October 30th, nearly two months later. Last, and most important: penicillin only works if it’s present before the staphylococci. Fleming did not know it at the time, but penicillin interferes with bacterial cell wall synthesis, which only happens when bacteria are actively growing. Visible colonies, however, are composed mostly of mature or dead cells. By the time a colony can be seen, it is often too late for penicillin to have any effect. In fact, the Penicillium mold typically won’t even grow on a plate already filled with staphylococcus colonies. For years, scientists have attempted to replicate Fleming’s original discovery. All have met with failure. Our latest essay, by writer @kevinsblake, explains these inconsistencies and points to what likely happened instead.

@often20000 @grok what is the actress's nme

Why do you keep pushing me away

@clairlemon The economic assessment is not about what they can do with the product in the near term, but the possibility of them achieving AGI intelligence explosion. This is seen as a winner takes all development that justifies investment with outlandish losses short term.

Ten billion dollars a quarter. 🫠 x.com/sethharpesq/st…

@CodeByPoonam Firefox 🦊

Which browser will you use now? - ChatGPT Atlas - Perplexity Comet - Copilot Mode in Edge - Google Chrome - Safari

@alex_prompter Guide

🚨 Perplexity just dropped something wild. It’s called “Perplexity at Work” their official guide to actually getting more done with AI. Not another “productivity tips” doc this is the real framework their own teams use to: → Block distractions & reclaim focus → Scale yourself like a 5-person team → Turn AI from noise into results It’s clean, practical, and honestly the most useful thing I’ve read on using AI for work not just chat prompts. Comment “Guide” and I’ll send you the full PDF (it’s 100% free from Perplexity)

Look, folks, I made a thing and people shared it :D

@SynBio1 Ironically, there is no safety rules for the builders of the AIs themselves. It is like we had said, "if we legislate for safety with GMOs then other countries will beat us to creating a super pathogen."

At the Asilomar conference in 1975, biologists chose to be pro-active about calling their own work risky 50 years later, you can’t ask AI for a PCR recipe without getting shut down like a bioterrorist My fellow biologists: this is our fault. We built this regulatory culture

@AllThingsApx Betteridge's law of headlines en.wikipedia.org/wiki/Betteridg…

Nope.*

@JeremyJBarr @SubDinesh @NatureMicrobiol Looks nice, Jeremy. Congratulations to you and your team.

Excited to announce the latest research published by our lab, which is led by Dinesh Subedi @SubDinesh and is out today in Nature Microbiology @NatureMicrobiol nature.com/articles/s4156…