al3x🦞

These studies are always fascinating to me. The internet has long suspected that low testosterone was a root cause of many societal problems. The mainstream doctors, academics, and journalists dismissed that thesis as a wacky, far-right conspiracy with no merit. The science is now undeniable though. Men with low testosterone are much more likely to go with the crowd and refrain from standing up for the right thing, rather than the popular thing. Quite literally, if we could increase the average testosterone levels in America, we could address a number of issues. The internet has known this for a long time. The wisdom of crowds is a real thing. Eventually the “experts” will learn to listen to the people.

ANNOUNCEMENT!!!! A lot has been happening in the singularity, and I realize many of you want me to share more of it. You've been asking for more behind the scenes, more founder content, and more strategic and actionable content beyond Moonshots. So, big news! I'm officially expanding. My team and I will be working to bring you more of these types of content and you can now find me on Instagram, TikTok, YouTube and Substack. Follow along and let us know what you think. We're just getting started!

@DaveBlundin Looking forward to this. Always appreciate your enthusiasm on the pod.

@DaveBlundin @OpenAI @Google The most under-followed man on X right here . Thanks for all you do DB.

Sam Altman said @OpenAI would deliver 100x cheaper intelligence by end of 2027. I said we'd get there in one year, not two. @Google's TurboQuant breakthrough compresses AI memory usage by 6x during inference, but everyone's missing the real story. It's not about running models on your phone. It's that the smartest AIs can now hold more context, or use 8x more thinking tokens, or you can train 8x larger models. We'll use some combination of those to get the best results. And this is just one of a dozen compounding breakthroughs. AI is helping improving AI, and that loop is accelerating. At this rate, we might blow past 100x by summer!

Wow. SpaceX/xAI to potentially buy Cursor this year for 60 billion $ This makes SO much sense xAI has been behind on coding products for years now Cursor has a great coding product, but will fail unless they build their own model xAI gets an incredible coding product. Cursor gets the compute infrastructure to build its own model instead of rely on its competitors (Anthropic and OpenAI) which would eventually lead to certain death This is probably happening to every 'vibe coding' tool out there The economics make no sense for them. You build a vibe coding tool but you are 100% reliant on Anthropic and OpenAI for models, who are at the same time building their own vibe coding tools, putting margins on your compute, and using models only they have access to to build faster Wins for both sides. I've been waiting years for a Grok Code. Hopefully this is the start of it

@DrDiGiorgio I’m wary of top down approaches of large hospitals implementing AI. Would like to see hospitals encouraging it from the ground up to allow the front line to solve their pain points. What’s been your experience?

So much AI potential is falling short in healthcare. Hospital admin are forcing doctors to copy-paste a clinic H&P into a new note for surgery instead of automating it. Hospitals are paying NPs mid-6-figure salaries to do chart review instead of automating it.

@AlexFinn Why can’t you buy a Mac Studio new with 512gb memory anymore?

It happened. An open weights model just dropped that benchmarks higher than Opus 4.6 is out If you have 2 Mac Studios w/ 512gb, you can run Opus 4.6 level intelligence completely for free on your desk I warned you this would happen months ago. Now Mac Studios and Mac Minis are sold out The next Mac Studio has been delayed until Q3/Q4. The price will be significantly higher I told you this was going to happen. Intelligence explosion. Hardware bottleneck. Increased efficiency Luckily I picked up 2 Mac Studio 512gbs, 2 Mac Minis, and a DGX Spark I will be loading this up in the next couple of days and will have completely private super intelligence running for me 24/7 I’m telling you right now by end of year we will have a local version of Mythos. It’s 100% guaranteed You called me crazy but every single prediction I’ve made has turned out to be true These models will only get more efficient and require less hardware. But that hardware is only going to get more expensive Local/open source is so obviously the future and if you’re still denying this now you are delusional

@doctorbhargav @DrDiGiorgio @blitzyai With Anthropic putting SaaS companies on notice, what about new entrants into EHR?

@ac253189 @DrDiGiorgio @blitzyai Possibly, but it will depend on how well those solutions integrate with existing systems. Overcoming infrastructure challenges isn’t just about adding new layers, it’s about aligning with how data is captured and used in real workflows.

AI can scale quickly. EHR infrastructure can’t. That mismatch is why progress feels slower than the hype.

when you switch your openclaw from opus4.6 to chatgpt5.2 and it breaks..

@bp22 To screen for the latter @KevinWSHPod has a hypothesis there’s usually some kind of chip on the shoulder or past traumatic event that leads to a hunger/agency you see in successful founders .

I've always found it easy to screen for intelligence/brilliance but very tricky/difficult to screen for agency/hustle/accountability. If you've been successful at consistently screening for both, what are your secrets?

@AlexFinn @alexwg @devontriplett21 @alpen can we get @echodotxyz access to this deal?

Biggest announcement of my life: I have raised pre-seed funding from 021T, @alexwg , and @devontriplett21 to build an AI agent that will change the world The biggest issue with AI is it is creating incredible value but for only a small group of people Most people hate AI and don't use it I have built Henry Intelligent Machines (HIM) to solve this HIM is a personal swarm of AI agents autonomously creating economic value for you 24/7 Right now as we speak HIM is collecting data across thousands of websites autonomously 24/7/365 They're hunting for challenges to solve at all times When you use Henry, he will deeply research you and get to know you. Then based on the thousands of opportunities it has in its database, find the value generating opportunities that most closely match your interests, skills, assets, and expertise Henry and its swarm will then proceed to build those micro-businesses out for you You will have complete control over the swarm. Reviewing and approving all work. Editing where you find appropriate. You give Henry a budget, then it hunts and autonomously creates value Say you have an expertise in vibe coding tools and Henry discovers there's no vibe coding guides on Gumroad. It will take your expertise, build drafts for a guide, run it by you, post with your approval, then use your budget to get customers Say you're into AI and speak Portuguese Henry will go through the Portuguese AI education market, see there are no educational products in that language, then create a full AI educational business in Portuguese Most people hate AI. This is because they get 0 value from it, see their friends getting laid off, and become scared HIM is the antidote to this. HIM allows ANYONE to get value from AI. HIM will allow anyone to get access to the trillions of dollars of value that are up for grabs in the new AI world. To ensure Henry creates value and not slop, this will be an extremely slow rollout We will be letting people into HIM 1 by 1. Working with them hands on to ensure Henry only builds real value for them, then expanding from there. If you'd like to be one of the early users of Henry, feel free to sign up at the link below. Forward.

@DrDeepMD Hard to believe not much has changed about questioning the status quo in medicine since Semmelweis

This is the worst advice I’ve ever heard Let me explain to you who most doctors are. Medical school selects for lemmings. The rule followers. The studious ones who put their heads down and did everything right. The dorks who were afraid of getting in trouble. How does that play out? Everything is “by the books”, you do what you are told by your professor or your attending, and then your administrative overlord or the insurance company paying you, and then you do that thing for the rest of your career without really questioning it. You have top cover by following the consensus, you can do no wrong by treating the lowest common population denominator. Most doctors read a headline or a guideline and just commit that to memory rather than understanding how data, research, and consensus is actually derived. There is a HIGH cost for questioning the status quo in medicine. If you question what the book says, or how we came to certain conclusions, or just ask WHY, you are punished and ostracized, not celebrated for the discourse and discussion. So, why then, would we bring abstract and rapidly changing information to a group of stale thinkers who are bred to toe the line? They will merely chastise you for questioning their authority and not have enough time to engage in dialogue with you about important topics you are curious about. I’ve been a primary care doc my whole career. My dad was a PCP for 50 years. I have many many friends and colleagues who I love and respect that are PCPs. It’s not their fault. The system really just doesn’t put people in these roles who are critical thinkers and will expose the grift for what it really is. They will forever be the muppets who have been surreptitiously co-opted by big pharma to be their lifelong peddlers. Many props to all those on the front lines who are trying to help people every day But. This is still the worst advice I’ve ever heard. And Dr Mike is a major dumbdumb

@BrentAWilliams2 🤣

If “The Pitt” was an honest show it would spend 80% of the show with scenes of residents sitting in front of screens staring at Epic.

Using OpenClaw is basically is like driving your own Ferrari (that you have to be a mechanic for yourself) and it's broken down all the time, but gives you the time of your life vs driving a reliable Honda (Hermes Agent) vs riding the bus (Claude / ChatGPT)

@DutchRojas Also, physicians should be asking themselves why are prices increasing yet professional reimbursements continue to decline? Consumers blaming docs for price increases when really it’s from administration bloat being passed on to the consumer.

@DutchRojas agree price controls is not the solution. I do understand consumers frustration with healthcare costs, especially when you look at this graph

99% of the entire globe do not understand first order and second order items. To wit: Look at all the healthcare solutions today. Second order at best. The grift just keeps on grifting.

Graduate degrees in medicine, law and pharmacy generally have the highest return on investment, a report found per WaPo. By contrast, advanced degrees in social work and psychology generally do not pay off financially.

@DutchRojas Dutch, why not raise $ through a SPAC and do a corporate takeover of a publicly traded hospital?

A Nepali immigrant in Louisville wanted to open a home health agency to serve refugees in their own language. A $2 billion hospital conglomerate told the state there was “no need.” The state agreed. That’s CON law in one sentence.