@VickersBiostats @ahmederaky No post sx lymphoedema in 1500 patients is unusual. Post RT tox data would be informative as a fu if available. There’s a lack of high level data in this space, thanks for publishing.
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Andy McPartlin
104 posts
Andy McPartlin
@ajmcpartlin
Radiation Oncologist @pmcancercentre
Toronto Katılım Eylül 2012
168 Takip Edilen164 Takipçiler
@ajmcpartlin @ahmederaky err... there was a trial. There as no lymphedema in the trial. But feel free to give an estimate of the increase in risk with lymphedema and its relative harm vs. mets and i'll run the meta-analysis.
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Defining utility as net metastases avoided and weighting metastasis 2,000× worse than lymphocele virtually guarantees PLND “wins” under almost any nonzero assumed benefit. That’s a value structure driving the result—not neutral inference.
Karim Touijer@TouijerKarim
in J Urol this month a decision analysis of PLND during RP Take home message: benefits of PLND outweigh risk for most patients. auajournals.org/doi/10.1097/JU… @VickersBiostats @UrologyMSK #prostatecancer @Uroweb @AmerUrological
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@VickersBiostats @ahmederaky Interesting idea. Major side effect patients would worry about is chronic significant lymphedema of the lower limb. Risk raised ++ by extended PLND and salvage RT. What value vs single met cured by sbrt. Conclusion seems overstated. Need trial ideally.
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@ahmederaky Yes, that is the whole point of decision analysis. You have the evidence you have, but a patient is coming in tomorrow and you have to decide PLND or not. That is why a key parameter is the subjective probability PLND is of value. Do give me yours and I'll rerun the analysis.
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Andy McPartlin retweetledi
Delighted to publish our work with @ajmcpartlin and the @pmcancercentre @UHN_Otohns @UofTDRO team on impact of PORT neck volumes on salivary fn in OSCC
-27% hyposalivation post-op
-⬆️RT neck volume predicts salvia fn recovery & chronic hyposalivation
doi.org/10.1002/hed.27…
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Andy McPartlin retweetledi
New in the #RedJournal: Phase 2 single-arm trial of SBRT for patients with oligoprogressive breast, genitourinary and gastrointestinal cancers: by 1 yr, ~1/2 of patients could maintain their current line of systemic therapy and ~1/3 had no progression. tinyurl.com/glicksmanrj
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Incredibly honoured to have been awarded the Steven A. Leibel Memorial Award by @ASTRO_org for our work on the UNITED clinical trial using adaptive RT for glioblastoma. #radonc @SahgalArjun @Sunnybrook @UofTDRO
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@CJTsaiMDPhD @imrtlee @MSK_RadOnc @MSKCancerCenter Kudos the the team. Great study, fantastic for patients. Question how much this is due to intrinsic hypoxia/radio sensitivity vs interaction with immune response. Awaiting the HPV -ve data 🍿
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🚨📢Happening now - HN oral abstracts #ASCO24‼️
PRACTICE CHANGING trial of hypoxia directed major radiation de-escalation as definitive treatment for HPV+OPC by @imrtlee @MSK_RadOnc @MSKCancerCenter, showing that 30Gy+Chemo is sufficient for cure, with > 500 pts treated so far.
🗣️Why should everyone be treated to 70Gy with large elective dose/volume ⁉️ Radiation does not have to be toxic in many selected patients based on hypoxia status.
@xrtGenomics @imrtlee @seanmmcbride @YaoCMKL
@yaoyu_md @Esanzgarcia @DrMLChua @KaramLab
@Dealmakertech @DanielMaMD @ScottBratman @JJCaudell @safaviaa @HenryParkMD @ajuloorimd @henson_md @RobertFerrisMD @ezrahahn @Dr_AliHosni @lucmorrisnyc @DavidSherMD @LChen_MD
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@simona_gaito @OfficialUoM @TheChristieNHS @RRR_UoM @marianneaznar @edsmith_mcr @FBMH_DocAcad Congrats Simona, fantastic effort to complete this through Covid era- real achievement!
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👩🏻🎓Something to brag-g about!
🗣️My PhD defence today was successful!
What a privilege it’s been to train in a world-class organization @OfficialUoM @TheChristieNHS @RRR_UoM with the most amazing supervisory team 🙏🏼@marianneaznar @edsmith_mcr
#celebrationsareinorder 🥳 🎉🍾
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Congratulations @swinton_martin 🎉
Radiation Oncology@UofTDRO
Delighted to share the success of the @UofTDRO & STARS21 Research Day 2024! A massive thank you to all who share their research accomplishments. #RadiationScience 👉Check out the highlights and award winner list here: bit.ly/3UtE41y @ldawsonmd @STARS21atUT
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@DavidSherMD Love the concept. GTV-CTV-PTV accounts for various uncertainties (clinician/imaging/ planning/set up etc) that vary between cases and centres. TROG 0202 LRC lower at smaller centers. Tighter margins may accentuate this. RTQA crucial.
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Fantastic idea! The reduction in normal tissue receiving higher dose is markedly reduced with a 0 mm CTV70 margin.
Some centers (many?) already have this policy. The more data published on lack of marginal failure, the better.
Endpoints for DAHANCA 41?
Chr Rønn Hansen@christian_roenn
The results from the #DAHANCA study on correlation between GTV-CTV margin and risk of local recurrence. @Ruta51463637 showed that margin does not seem to influence the risk 🤔 and presented the idea of the next DAHNCA 41 trial. 0 vs 5 mm margin 💪🇩🇰 #ICHNO24
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@ezrahahn @CJTsaiMDPhD @Dr_AliHosni @ScottBratman Agreed. The primary site outcome is fascinating too in comparison to E3311. Lots to think about.
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@CJTsaiMDPhD @ajmcpartlin @Dr_AliHosni @ScottBratman Agreed. Time to move on ENI dose. And with more data emerging soon time to move on ENI volume (lots of separate discussions on this point). For some volumes low dose works because it probably doesn't need treatment at all.
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@5_utr @gminniti2012 Yep, exactly - at 12 months even PFS curves meet. But think - in the interim you got to go to the doctor's office more and have more treatments and labs etc. And then the graphic - at least have the radiation hit the head region.
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Do these results justify its use? Superiority over WBRTdoesn'mean that is better than other safer approaches
JAMA Oncology@JAMAOnc
Induction bevacizumab, cisplatin, and etoposide (BEEP) preceding whole-brain radiotherapy (WBRT) improved brain-specific progression-free survival as compared to WBRT alone in metastatic breast cancer patients wi/ brain metastasis irrespective of subtypes. ja.ma/3GQk82q
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@DavidSherMD @JoaquinJCabrera Had a demo yesterday- lots of possibilities!
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@JoaquinJCabrera In my opinion, it is a game-changer for CBCT-based ART. It's not a perfect solution when there is motion, but I am very impressed and excited to see studies coming out using this technology.
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@simona_gaito @royalmarsdenNHS @ALESSIOBRUNI10 @gminniti2012 @marianneaznar @edsmith_mcr Excellent news, congratulations!!
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🎄Busy holiday season for me as I get ready to take on my new role as a ClinOnc Consultant @royalmarsdenNHS. My special thanks to everyone who has supported me throughout this journey,offering a space to discuss career aspirations and challenges #whereishoskin#profananya #nburnet
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@MCRCnews @marianneaznar @OfficialUoM @RT_physics @UoM_DCS @finn_corinne @Al_McWilliam @FBMH_UoM @KathrynBanfill @AngieDavey_ @achoud72 Congratulations!! Truly well deserved.
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A MASSIVE congratulations to our very own @marianneaznar who has been newly promoted to a @OfficialUoM Professor 👏
We are absolutely delighted for you, and we cannot wait to see what your future in radiotherapy and medical physics holds 🥼
#radiotherapy #medphys
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I am humbled and honoured to share that I will be starting as a visiting Professor in OMFS H&N Surgery at Edge Hill University from August 2023
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Dose to inferior brain stem is associated with dysphagia at one year following RT for HNSCC.
Great work by @elivaos @AzadehAbravan and @DebGandertonSLT, true multidisciplinary project!
sciencedirect.com/science/articl…
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Proud as the UKs first proton trial completes recruitment & ahead of schedule too!
Many thanks to the patients, and all involved. It’s been a huge team effort!
Very grateful to @CRUKresearch for funding the trial and @RTTQA_UK for their superb work.
Follow us on Bluesky @ICR-CTSU@ICR_CTSU
The TORPEdO #ClinicalTrial reached its target enrolment of 205 participants this week. Thank you to all participants and colleagues involved in TORPEdO.
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@EliDScher @JamesBatesMD Full paper currently with reviewers, hopefully out soon 🤞🏻
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Medulla dose matters in dysphasia risk in oropharyngeal cancer treatment - from Eliana Vasquez Osorio #ESTRO23
Vienna, Austria 🇦🇹 English