Alberto Indacochea

Discovery of a new biomarker (RNAPII) in cancer that denotes aggressiveness, increased risk of recurrence, shown in breast cancer and meningioma (<-Figure) @ScienceMagazine science.org/doi/10.1126/sc…

Using multimodal A.I. to more accurately predict a person's risk of cancer (and other conditions) by combining proteomics and electronic health records nature.com/articles/s4225… @NimaAghaeepour @NatMachIntell open-access

The effects of GLP-1 drug (semaglutide) on the proteome shows broad impact, potential relevance to many diseases beyond obesity nature.com/articles/s4159… @NatureMedicine

Nivolumab plus Ipilimumab in Microsatellite-Instability–High mCRC @NEJM doi.org/10.1056/NEJMoa… 🔎CM 8HW phs-3, 303 pts 👉24-mo PFS: 72% vs 14% 👉AEs Gr 3/ 4: 23% vs 48% 💪Excellent outcome w/ ICI,incl pts with liver mets, mBraf... @myESMO

The problem with "open #AI systems" is that they're not open. @Nature nature.com/articles/s4158… "We reveal a map of open AI which shows that.... [it] is highly dependent on the resources of a few large corporate actors, who effectively control the AI industry and the research ecology beyond."

For readers interested in bispecific antibodies as cancer therapies, here's a comprehensive recent review nature.com/articles/s4157… rdcu.be/d1w34

Happy to share our new paper from @katherlab , led by @Dykex6 , which was just published in @NatureComms. In-context learning enables general-purpose vision language models to perform well on medical image analysis tasks. We don't need to train a neural network at all - just provide a handful of examples at inference time. nature.com/articles/s4146… PS: follow me on jnkt.bsky.social

Late-line options for patients with metastatic colorectal cancer: a review and evidence-based algorithm An excellent review👇 nature.com/articles/s4157…

Neoadjuvant nivolumab & relatlimab in locally advanced MSI CRC @NatureMedicine doi.org/10.1038/s41591… 🔎NICHE-3 phs 2 👉PR 97%, MPR 92%, pCR 68% 👉only one recurrence 👉Gr 3–4 irAEs 10% 💪Impressive, we need to find the most effective, least toxic combination @myESMO

ctDNA-based MRD & survival in resectable CRC @NatureMedicine doi.org/10.1038/s41591… 🔎CIRCULATE-🇯🇵 GALAXY, 2,240 pts 👉shorter DFS in MRD+ patients 👉Better outcome after sustained ctDNA clearance in response to ACT 🧐What else do we need to implement into clinical practice? @myESMO

Adjuvant immunotherapy in pts with resected GC/GEJ cancer following pre-OP CTx with high risk for recurrence (ypN+m R1) doi.org/10.1016/j.anno… 🔎EORTC 1707 VESTIGE, 195 pts 👉DFS 11.4 vs 20.8 mo 🧐Nivolumab/ipilimumab does not improve DFS, CTx remains best option @myESMO

Ramucirumab/paclitaxel as switch maintenance vs continuation of FOLFOX HER2-negative GC/GEJ cancer @TheLancetOncol doi.org/10.1016/S1470-… 🔎ARMANI phs 3 👉mPFS 6·6 vs 3·5 mo 👉mOS 12·6 vs 10·4 mo 🧐switch maintenance could be an option for pts who are not eligible for ICI/🎯💊 @myESMO

Concordance of ctDNA and tissue genomic profiling in biliary tract cancer @JHepatology doi.org/10.1016/j.jhep… 👉concordance in 84.8%, 👉ctDNA revealed 🎯GA in 34.3% 👉high VAF in ctDNA associated w/ poor prognosis 🧐LB valuable option @myESMO @EASLedu @ILCAnews @curecc #livertwitter

A highly innovative, potential breakthrough in synthetic biology: engineered receptor platform to activate specific cells based on their cell surface molecules, such as immune response to cancer nature.com/articles/s4158… @Nature @UCSF @KoleRoybal @roybal_lab @parkerici @piraner

REVIEW: CAR-engineered NK cells versus CAR T cells in treatment of glioblastoma; strength and flaws link.springer.com/article/10.100…

Add custom text styling to your ggplot2 visualizations with ggtext, an extension that brings advanced text formatting options directly into your R plots. With ggtext, you can use Markdown and HTML to style plot text, allowing you to incorporate features like bold, italics, colors, and more complex layouts. Key benefits of using ggtext include: ✔️ Enhanced Aesthetic Control: Style individual plot titles, labels, and annotations with Markdown or HTML, providing precise control over text appearance. ✔️ Custom Formatting: Easily mix and match text styles within the same plot element, such as adding bold or colored text to specific words in titles. ✔️ Dynamic Styling Options: Customize plots to align more closely with branding or design standards, improving clarity and visual appeal. Using ggtext in ggplot2 is straightforward. By replacing standard text elements with element_markdown() in the plot’s theme, you can apply rich formatting to elements like plot.title, axis.title, and legend.text. This flexibility enables you to bring text to life in your plots without needing external design tools. The example visualization shown here is from the ggtext package website and demonstrates these formatting features: wilkelab.org/ggtext/ To learn more about creating visually compelling plots with R, check out my course, "Data Visualization in R Using ggplot2 & Friends," starting November 25, 2024! Learn more: statisticsglobe.com/online-course-… #ggplot2 #Statistical #datavis #RStats #Rpackage #datasciencetraining

REVIEW Epigenetics behind CD8+ T cell activation and exhaustion nature.com/articles/s4143…

Molecular profiling of mBRAFV600E mCRC @NatureMedicine doi.org/10.1038/s41591… 🔎BEACON phs-3 👉No impact of CMS, BM subtypes, GA (incl. RNF43), MSI or TMB on efficacy 👉more benefit w/ MEKi in immune-activated tumors? 👉interesting analysis on acquired resistance mutations @myESMO

The relationship of physical activity and life expectancy bjsm.bmj.com/content/early/… Summary points from the paper: —Americans over the age of 40 could live an extra 5.3 years if all were as active as the top 25% of the population. — For the least active 25% of Americans, an extra hour’s walk could add 6.3 hours of additional life expectancy.

Drug discovery is hard! Despite decades of efforts, there's still only one target in the DNA damage response with an approved inhibitor: PARP