Amal Asar, FRCPath, MAcadMED

Middle aged female, presenting with small intestinal obstruction. Very characteristic macroscopic picture. Micro to follow.... #grossognosis #gipath

One of the major educational initiatives in #Pathology, one of the most impactful step for democratization and digitalization of education in Pathology Thanks to you I have learned and continue to learn so much. Heartfelt congrats Dear Friend @mannanrifat03 for the 300th PathCast

Not everything is what it seems. Middle-aged patient. Consult case. Minimal clinical data. Ileal resection for obstruction → tumor found. Let’s follow the diagnostic trail. Short thread, do the polls in order (and no sneak peek...)

@Baskotacytopath @DrGeeONE @aproko_doctor @pathologistmag @Pathologists @TheUSCAP @JMGardnerMD @smlungpathguy Well deserved Leke! I have been off “twitter - as it will always be to me” for quite a while now, trying to get back slowly. Was really pleased to see the feature on the Pathologist. I hope you are keeping well

@DrGeeONE @aproko_doctor @pathologistmag @Pathologists @TheUSCAP @JMGardnerMD @smlungpathguy @drhephzibah1 Congratulations Leke! @DrGeeONE ! You deserve it!!

Power list 2025 I was featured on “The Pathologist” Power List 2025: Leading Voices Edition. It is a privilege to be counted among those considered as “inspirational figures behind innovation and achievement in pathology and laboratory medicine” It didn’t stop there; I was voted one of the readers’ favourites, and I am grateful to you all! My interview has just been published: thepathologist.com/issues/2026/ar… youtu.be/q_svuJTWi28?si… @Nigerian_Doctor @DrJoeAbah @enodamade @DrKamleshDarji1 @Just_JONIER @chriszioga @SumantaDas_7 @pepeheffernan @Baskotacytopath @VarshaManuchaMD @mdlozanoe @01sth02 @LJTafeMD @Dr_Jukic @kriyer68 @LaraHarikMD @NebbacheHafsa @HENRYY_MD @SGottesmanMD @RunjanChetty @HermelinMD @darcykerrMD @sakhurram @Pathmath1 @kis_lorand @edusqo @ariella8

🧪What's the significance of⬆️mast cells found on gastrointestinal mucosal biopsies? We reviewed the @MayoClinic @MayoClinicGIHep experience. Check out what we found! #MedTwitter #GITwitter #inflammation #IBD #pathology #mastcells #SIBO #microbiome

In this talk at will try to explore how large scale implementation can shift how we work and train as Pathologists, and shed a light on requirements to be respected while working with AI in the hybrid workplace, to maintain patient safety and preserve Pathologists’ identity.

Large polypoid lesion on the ileocecal valve. What is your diagnosis? 🔬 #PathTwitter #GIPath #BSTPath #pathresidents #pathfellowss

Case of Metastatic Lobular Carcinoma to Gallbladder ☄️🔬 Chronic cholecystitis on the requisition? 🤔 Those dyscohesive cells in the wall might tell a different story 😦 #PathX #PathTwitter #breastpath

gastric biopsy from an old man what do you think is going on here? #GIpath #PathTwitter

Another frightful feature 🧛‍♂️ haunting pathologists 😱 this spooky season 🎃 Case of Microglandular Adenosis 👻🔬 Small round glands with bright eosinophilic secretions🩸infiltrating fat without myoepithelial cells that mimics invasion. 🧟‍♂️ #PathX #PathTwitter #breastpath

Not my typical #gupath #gynpath post but an interesting one for trainees! Colon biopsy for GI bleed, clinical concern for IBD. #pathboards

Happy Saturday everyone! Let's discuss our Breast Consult Case of the Week 3 #BCCW #breastpath #PathTwitter Like everyone astutely pointed out, the diagnosis is adenomyoepithelioma (AME). Adenomyoepitheliomas are biphasic tumors of the breast, and they may encompass a variety of patterns, potentially making their diagnosis challenging. In my experience, the most common pattern of adenomyoepithelioma is papillary with a neoplastic population of spindled myoepithelial cells. This is however not the only way these tumors can show up in your practice. As a matter of fact, when the lesion is papillary in nature, one may question whether one is dealing with adenomyoepithelioma or an intraductal papilloma with myoepithelial hyperplasia. I believe the key to diagnosing these lesions is to recognize the neoplastic nature of the myoepithelial cells, both morphologically and quantitatively, meaning that they should be increased in number independently of the epithelium, and the myoepithelial cells themselves should be morphologically abnormal (enlarged, potentially with prominent nucleoli, often with a clear cytoplasm). In the above case, the myoepithelial cells just appear enlarged and spindled, and growing in what appears to be a clonal process. One of the main controversies linked to adenomyoepitheliomas is their reported potential to behave in a malignant fashion without necessarily showing malignant histology. This is fortunately exceedingly rare. What I often observe however is the potential progression of adenomyoepithelioma to atypical and malignant forms. Here are some morphologic and immunohistochemical clues to the diagnosis. 1. AME can sometimes consist of infiltrative looking tubules and when you stain it for myoep markers it will be variably positive and hence confusing, so if you don’t think about it you might easily miss it 2. Squamous and sebaceous differentiation are sometimes seen and are a clue to the diagnosis 3. Avoid calling malignant AME if it’s cytologically atypical but well contained. Atypical AME works most of the time 4. Densely hyalinized stroma is common due to deposition by the myoepithelial cells, and often surrounds the whole lesion. Trickling of neoplastic cells beyond the hyalinized stroma might be reason for concern 5. Aberrant staining patterns for myoep markers are common, like in this case where p63 is lost in much of the spindle cells. That’s actually a clue to the diagnosis. The topic is of course highly complex and diverse for a such a rare lesion. The key, I think, is to remember this entity when dealing with a lesion that doesn’t seem to make sense and consider it in your differential diagnosis. Here’s a very good paper by Dr Rakha addressing the many complexities of AME. Rakha E, Tan PH, Ellis I, Quinn C. Adenomyoepithelioma of the breast: a proposal for classification. Histopathology. 2021 Oct;79(4):465-479. doi: 10.1111/his.14380. Epub 2021 Jun 13. PMID: 33829532. @washupathedu @washu_pathology

Check out this Differential of Smooth Margin Lesions of the Breast 👇👇👇 thepathprincess.substack.com/p/breast-core-… Mostly benign, but not always!

@RahulADeb May she rest in peace Rahul!

Sad to hear Dr. Borges is no more. An icon in pathology & a teacher who shaped us all. Her "bring any slide" teaching sessions were masterclasses & lesson to "speak the surgeon's language" stays with me. Her legacy lives on in her students for generations. RIP Ma’am. Thank you

@fouad_boulos @washupathedu @washu_pathology Interesting case Dr Boulos. I feel the bits that look epithelial are slit like spaces, and I acknowledge the hyalinised background. Not sure I can see true epithelium. Myoepithelioma? Or myofibroblastoma?

Happy Monday everyone! Time for our Breast Consult Case of the Week 3 #BCCW. This is a 65-year-old woman with an 8 mm breast mass. The last image is an immunohistochemical stain for p63. What is your diagnosis? #breastpath #PathTwitter @washupathedu @washu_pathology

For a #Pathology within the reach of all #pathologists in the world, in complexity one must simplify for the patients good Much thanks Dear Colleagues for this paper: “Proposals to make diagnostic criteria truly usable and useful to pathologists worldwide” jcp.bmj.com/content/early/…

@atman_ci Nice read Luca, with interesting viewpoints.

So I start my morning today with these guys....

Enjoying the day so far at the brilliant London GIT course where a fantastic line up of local and international experts are sharing wisdom on various treacherous GI topics @London_GI_Path Looking forward to a week of knowledge and fruitful conversations. #pathtwitter #GIPath

@DrMarkOng A treasure post. Bookmarked!

The different faces of immunoglobulin in B-cell and plasma cell neoplasms. They can deposit as crystals. Tweet below was a DLBCL, this picture was a plasma cell myeloma. twitter.com/DrMarkOng/stat… #hemepath #pathology