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"My work doesn't define me, but it excites me." ~ Eric Dane (1972-2026)
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Christopher A. Baker
8.3K posts
Christopher A. Baker
@bakermind
Firstgen in Yale Center for Infection & Immunity using imaging technologies to study pain in long COVID and similar syndromes. https://t.co/Dhf7B783IT
JP➡️TX➡️PI➡️OH➡️CT➡️FL➡️WA➡️CT Katılım Ekim 2012
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@MaxJordan_N AI wouldn't have helped her much, but maybe it wouldn't have insisted on antibiotics to treat fungus because the doc "didn't want to 2nd guess the attending"
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@MaxJordan_N That is, if you get to see a doctor.
My wife, with an unresolved week long ear infection (despite two trips to the ED), was given an appointment in 30 days. Because she is a nurse there we eventually got an appointment within a week to confirm aspergillus & ruptured eardrum
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Unlike AI we can do a physical exam. Listen to your heart and lungs. Trigger reflexes to assess them. Rotate/flex/extend your joints. Check for rebound or guarding. Appreciate allodynia. Yall say what you want about AI vs doctors but AI is far from being able to replace us.
Nikhil Krishnan@nikillinit
you can also prompt doctors incorrectly by giving them wrong information and their output will be wrong too
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@akoustov @phylogenomics Who wants to waste the time to review these sloppy papers? I'll just get an AI to do it oh wait
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Enough is enough. Just because you can generate an academic paper in minutes doesn't mean you should.
When your name is on something, you should check every reference and claim before submitting. If you can't be bothered to do that, you should be banned from submitting.
Ilias Alami@IliasAlami
Reviewing yet another academic paper full of hallucinated references, odd citation practices, and improperly attributed material. To all academic colleagues out there, literally ruining our profession: thanks for nothing.
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@DrSamuelBHume Why expect an effect? People just throw GLP1s at everything for some reason. I can guess the reason
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Trials of oral semaglutide in early-stage symptomatic Alzheimer’s just published
Two big, well-designed trials, and unfortunately, absolutely no effect:
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@thehealthb0t Dude then how do people who never got a chickenpox vaccine go on to get shingles? Don't lie
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RFK JR - Many don’t realize, the Chickenpox Vaccine Causes shingles Epidemics
“When the CDC was thinking about mandating the chickenpox vaccine for your children, they did a study.
The person they hired to do that study was a scientist named Gary Goldman, who did a long-term study in California.
What he found is that if you give the chickenpox vaccine, mass vaccinate, it stops chickenpox, but causes shingle epidemics later on; which is 20x deadlier.
Despite those studies, we mandated for American children in this country, but in Europe they don’t.
If you go to the British National Health Service website right now, you can read that it will say, “We do not recommend chickenpox vaccines because it causes shingles epidemics later on… and that’s the problem.
(Check the link here: nhs.uk/vaccinations/c…)
You can’t say this product is going to prevent this particular disease, but you have to look at the long-term implications.”
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What's on my twitter feed nowadays?
1. Bread causes schizophrenia
2. Vaccines cause influenza
3. AI makes coders worse
4. AI, not particle colliders, will solve physics
perhaps some are true and some are not
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@LocasaleLab what about it isn't true? The closest thing to distortion is that there isn't _exactly_ 90% less funding, it's just that the funding has been appropriated by Congress but hasn't been doled out because RFAs aren't happening. The graph is accurate regardless of quotation marks
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Thank you, Carlos. This is one of countless examples of social media influencers pushing misleading narratives to support a negative thesis about NIH. I saw many of these circulating, often echoed by science media using the same framing. It is a coordinated distortion of reality. Some of it even relied on statements from Jeremy Berg, who spends much of his time trolling and harassing the NIH director.
Carlos E Alvarez@CarlosEAlvare17
Exhibit A: "we now have 90% less funding for medical research... We are sacrificing our children's future", illustrated with a 'scientific graph' labeled FUNDING CALLS PLUMMET and accented with a big red arrow That was a reprise of 2024's proclamations of the same Not mentioned were the last 3 NIH budgets signed into law: - 2024, ~$47.6B - 2025, ~$48.3B - 2026, $48.7B In other words, this is what we get when 'Science is Truth' meets 'The end justifies the means'
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@nickpretnar @HistedLab @ben_golub Hahaha good one. Universities will dismantle something, but I'm not sure it will be administrative bloat.
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@HistedLab @ben_golub On the bright side it could force universities to seriously dismantle bureaucratic bloat, some of which was driven by ballooning implicit costs in grants being taken up by various regulatory and compliance requirements.
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Writing out a conversation I’ve been having a lot at this conference:
Things in US science are far, far worse than people know.
Far worse than even other scientists know.
1/
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@GregoryMaysMD @EricTopol And many are handing out GLP1s like fast food, with mediocre efforts to provide therapeutic "environment". This happened previously with SSRIs and opiates. These drugs are shiny objects whose short term effects are difficult to ignore but whose long term consequences are unknown
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@EricTopol Short-term data are reassuring, but context matters.
GLP-1s lower intake — so outcomes depend heavily on protein and resistance training.
Without that, you will lose lean mass.
The drug isn’t the whole story — the environment you create while on it is.
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A study asserts lack of disproportionate loss of muscle mass or strength cf weight loss from GLP-1 drug treatment, in mice and a small short term (12 weeks) trial in men
The issue remains unsettled and counters the efforts by companies making GLP-1 drugs working on strategies to increase muscle mass cell.com/cell-reports-m…
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Christopher A. Baker retweetledi
@CameronCorduroy I had a $600,000 over 5 years NSF Physics grant terminated last year because our grant mentioned "polarization" which was included in the banned terms list. We were discussing the polarization of light. We never got the grant reinstated.
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@MichaelLinLab Yes, trust but verify. The experts tell me that it can be a waste of resources. My guess is that a second method applied to the same RNA is just a technical replicate. I'm more inclined to use RNAseq as a screen for genes to pursue in biological replicates (new experiments)
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@bakermind "If"
Maybe validation would be good to make sure the if statement is true?
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As someone just doing HTS for DNA and never having done RNAseq, I find this very interesting. Interesting that some people would base entire research proposals to understand disease mechanisms on RNAseq with no other plans for validation or follow up.
Ming "Tommy" Tang@tangming2005
1/9 Every bulk RNA-seq experiment I run goes through the same 7 checks before I trust the results. I've been burned enough times to know: if you skip QC, you will find out the hard way. Usually during a meeting with your collaborator. Here's my checklist:
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@CaryKelly11 @simonmaechling So you rely on scientists saying that scientists are fake as proof that you don't trust scientists? How meta.
Just like in society in general, the future scientific literature will endure a deluge of low quality slop from which we must extract meaningful info
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In this review of 75 statin studies, every single industry funded study found favorable results.
EVERY. SINGLE. STUDY.
37% of independent studies found unfavorable results.
So, if someone tells you that the majority of science supports statin therapy, remember that the income of scientists often depends on their scientific outcome.
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@amymitchellart @TypeItResist @NotOstriching That's what I mean: we still don't know the exact mechanisms. Lots of people will have EBV, but it will lead to MS in some via autoimmunity. Lots of people have varicella, but shingles occurs when it emerges from latency. We need more info than just presence of viral reservoir
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Judging by the GI study, no spike/virus is the right amount of virus. Even the small amount was doing bad things.
Failure to clear feline coronavirus leads to FIP later in life for cats. For some it happens sooner than others. I think that's the best comparison, if I were making a bet. That and HIV, as i've already said.
Those herpesviruses aren't benign- shingles and Alzheimers result.
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Were people with HIV denied the right to know they had it prior to the existence of antiretroviral treatments?!?!
NotOstriching@NotOstriching
So is that enough reason to hide the knowledge of generalized viral persistence from the public? I believe we have a right to know.
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@christopherrufo Trump does the same thing. It's just law 101. But I don't think "productive" is the word you seek. By definition they were "destructive": they removed things but did not add any value (no deficit or debt was reduced)
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The DOGE kids are getting deposed because the Left knows how to impose costs. The ACLU harassed me for years, ran up my legal bills, because of my work eliminating woke with DeSantis. They have a whole playbook for punishing productive right-wing people.
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@micyoung75 @Ti_Enjoli This shows that these dudes, and AI, are often performing brain surgery with a chainsaw. Kinda like that guy in Argentina. At the end of the day people will realize that they needed some of the bits of their brains that the chainsaws obliterated... but it will be a bit late
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A former investment banker named Justin Fox sat under oath for six hours and could not define the word he was hired to police. He used ChatGPT to flag grants containing "Black" and "homosexual" but not "white" or "caucasian." He canceled a Holocaust documentary. He axed a museum's HVAC repair because an AI decided "diverse audiences" might someday visit.
He had no legal authority to cancel any of it. The depositions confirm that. The $100 million in already-appropriated funds he helped torch? Congress approved that. DOGE overrode it anyway, on a spreadsheet, with a chatbot.
Efficiency is a serious word. It means knowing the statute, the precedent, and the human cost of every cut. What the NEH depositions prove is something simpler and more damning. These weren't reformers. They were people with access and no accountability... and a very poor grasp of American history.
Pod Save America@PodSaveAmerica
The DOGE-bags's deposition reveals a lot. Credit to @404mediaco for finding the clip.
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@amymitchellart @TypeItResist @NotOstriching ... SARS-COV-2 is starting to look more like herpesviruses. Lots of people harbor them in a state that isn't pathological. But others experience dramatic symptoms that ensue from the presence of these viruses. In neither case do we really know the molecular mechanisms involved.
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@amymitchellart @TypeItResist @NotOstriching There is effort in the research community to subdivide LC - many recognized from the beginning that there were going to be multiple factors leading to "phenocopies". Maybe there is a subset for which viral "persistence" is pathogenic. But what does "load" or persistence mean...
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