Bigtomato

52 posts

Bigtomato

Bigtomato

@Bigtomato22

Katılım Şubat 2026
9 Takip Edilen2 Takipçiler
Bigtomato
Bigtomato@Bigtomato22·
@ElonMuskSmall Well wool has very little value, so would it be worth it?
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Elon Musk Small
Elon Musk Small@ElonMuskSmall·
How can we call this kind of innovation😂🤣😇 ???
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Global Statistics
Global Statistics@Globalstats11·
Countries where over 90% of the population can speak English
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Statistics World
Statistics World@SachinGadagin·
@Globalstats11 It’s impressive to see Singapore, Ireland, and New Zealand on this list. Strong education, international business, and everyday exposure to English probably play a huge role.
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Bigtomato
Bigtomato@Bigtomato22·
@Ahmadullah_Faiz @stats_feed I travel to Argentina most years, if I can. It's quite a bit more expensive here, now that the Blue Dollar/Euro exchange rate is the same as the Bank. I literally used to be able to change my cash for double the official rate, even by sending it by Western Union!
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Qais
Qais@Ahmadullah_Faiz·
@stats_feed So Argentina lose tourists because of world cup?
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World of Statistics
World of Statistics@stats_feed·
Countries LOSING the most international tourists, change in arrivals 2019-2025: 1. 🇮🇱 Israel: -71% 2. 🇮🇪 Ireland: -32% 3. 🇦🇷 Argentina: -23% 4. 🇵🇪 Peru: -22% 5. 🇹🇭 Thailand: -17% 6. 🇪🇪 Estonia: -16% 7. 🇭🇺 Hungary: -15% 8. 🇱🇹 Lithuania: -15% 9. 🇱🇻 Latvia: -14% 10. 🇺🇸 U.S.: -14% 11. 🇨🇦 Canada: -11% 12. 🇳🇿 New Zealand: -9% 13. 🇩🇪 Germany: -6% 14. 🇨🇷 Costa Rica: -6% 15. 🇦🇺 Australia: -6% 16. 🇮🇹 Italy: -5% 17. 🇷🇴 Romania: -4% 18. 🇮🇩 Indonesia: -4% 19. 🇸🇰 Slovakia: -2% 20. 🇨🇭 Switzerland: -1% Source: OECD Tourism Trends and Policies 2026
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Afshine Emrani  MD FACC
Afshine Emrani MD FACC@afshineemrani·
I'm a cardiologist. Everyone is sharing this study as a skin story. They're burying the part that matters. Scientists took the aorta of a 75-year-old donor, applied a single engineered enzyme, and stripped away more than 70% of the molecular damage — bringing it down to the levels you'd see in a 30-year-old artery. Published five days ago in Nature Communications. Revel Pharmaceuticals, with Calico and the University of Colorado. Here's what they erased. Sugar reacts with proteins in your body the same way heat browns bread — slowly, over a lifetime. It leaves behind a residue called CML, the most abundant advanced glycation end product in aging tissue. It welds itself onto collagen and elastin in your skin, your eye lens, and your arterial walls. Two things follow. Your arteries stiffen. And CML latches onto a receptor called RAGE, which drives chronic inflammation — the exact fire I've been writing about for months as the engine of heart disease. Since the 1980s this damage was considered permanent. Your body has no enzyme to remove it. Every existing approach only slows new damage from forming. Nothing touched what was already there. So they built an enzyme that doesn't exist in nature. They screened 45,000 protein structures, then ran five rounds of directed evolution across more than 500 million variants until they had CMLase — a molecular lawnmower that oxidizes the CML off the protein and restores the original, healthy lysine underneath. Not patched. Reversed. Over 70% cleared from elderly arterial tissue. Over 55% from elderly skin — below the levels found in 31-year-old skin. 45-78% in lens proteins. The CEO said they expected 20% and were floored. Arterial stiffness drives systolic hypertension, heart failure, and stroke, and I have no drug that reverses it. I can slow the process. I cannot undo it. This paper says undoing it may be possible. The caveats are real and I won't skip them. This was done on donated tissue in a dish, not in a living person. No functional data yet — we don't know if that artery got measurably more elastic. Delivering a large enzyme deep into human tissue is a hard, unsolved problem. Clinical trials are years away. But something considered permanent for forty years just came off human tissue. We spent a century learning to slow aging. Someone finally figured out how to erase it. Thank you @theallinpod @friedberg @chamath @pesottas
The All-In Podcast@theallinpod

Friedberg: New study shows enzyme reverses skin age from 70+ years to 31 Chamath: That’s a $2T market. Did Scientists Just Discover How to Reverse Skin Aging!? “CML is kind of the predominant molecule that gets formed in this extracellular matrix that's driving aging, and nothing breaks it down. So these scientists set out to try and create an enzyme, an enzyme is a protein that breaks something down, that can break down CML. And so these guys kind of went out and they took the target, which is CML, and tried to figure out, ‘Okay, how do we actually degrade CML, clear that extracellular matrix, and reverse aging?’ They started to test it on the proteins that we would find in our body, casein, collagen, retinal proteins, which are in your eye, hemoglobin, and they were able to get rid of 52 to 97% of the CML, just degrade it away. And then they found several sites where they were able to degrade over 90%. And then they took actual human skin from elderly patients that had donated their skin, and they put this enzyme onto that skin, and they were able to eliminate 55% of the CML on the skin, basically reverse the skin's age down to the age of a 31-year-old, this is from greater than 70-year-old patients, just by putting this enzyme on the skin. And so it's kind of a groundbreaking demonstration of combination of AlphaFold, what's called directed evolution, where you change the order of the DNA that changes the structure of the protein to test different proteins, do high throughput screening, and ultimately make a novel protein that doesn't exist in nature today that can do something pretty profound for human health.” Chamath: “It will be a trillion-dollar market. If you can create a cream…” Friedberg: “I mean, dude, if you could put this enzyme literally on your skin and have it absorb in…” Chamath: “Game over. That alone is $2 trillion.”

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Kolade
Kolade@uttdkola·
🚨Pyramid of the Greatest dribblers all time 🐐 Thought?
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Bigtomato
Bigtomato@Bigtomato22·
@DanielP_ar @gonzalezbruno Well, the team that played their semi final first usually wins the world cup. But, all in all, they done well to go so far this time.
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Daniel P
Daniel P@DanielP_ar·
@gonzalezbruno Mi teoria es que se puso toda la energia en el partido contra inglaterra Tanto del equipo como de la hinchada y llegamos agotados.
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Bruno González García
Bruno González García@gonzalezbruno·
Conclusiones 🇦🇷🇪🇸: 🔸Futbolísticamente España fue muy superior 🔸Físicamente España fue muy superior 🔸El partido de mayor superación sobre Argentina en todo el ciclo Scaloni. 🔸El mejor partido de Dibu en el Mundial 🔸Tagliafico demuestra que es la mejor lateral izquierdo de la historia de la Selección. 🔸Muy mal partido del mediocampo. Los tres del medio no pudieron armar una jugada. 🔸Tuvimos un tiro en todo el partido. 🔸La roja de Enzo está bien sacada. Gesticula en la primera y llega tarde en la segunda. 🔸Messi insinuaba peligro las pocas veces que llegaba una pelota. 🔸Mucha mala leche que se rompan los dos centrales y el cuatro. 🔸Hay responsabilidad de Molina en gol. 🔸El amor propio del equipo nos llevó a tener vida hasta el final. 🔸Orgulloso de esta camada. 🔸Scaloni no te vayas. 🔸Muchas gracias Selección.
Bruno González García tweet media
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Bigtomato
Bigtomato@Bigtomato22·
@ChiTownSports It's actually to torture the loosing semifinalists. Maybe it's hard to appreciate, loosing in the semifinals is the worst.... you were that close to walking out on the greatest stage,and having a shot at glory, But no, you can't just go home, you have to play the other loser 😣🫣
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Steve
Steve@ChiTownSports·
I noticed on the #WorldCup schedule that they actually play a 3rd place game and I wonder why. Does any one of the final four actually care who finishes 3rd?
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Carl
Carl@Just_Carl__·
@theawayfans David Batty. Messi be proper fucked.
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The Away Fans
The Away Fans@theawayfans·
If you could bring back one former England player for Wednesday’s semi-final against Argentina, who would you choose?
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Bigtomato
Bigtomato@Bigtomato22·
@OginiSolomon England.. though on paper... A paper tiger in reality
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Soloball🇵🇹
Soloball🇵🇹@OginiSolomon·
I just realized Argentina have scored more goals than France with an attack of Mbappe, Olise, Dembele and Doue. That's an incredible stat to be honest. Then I realized that Argentina has been playing Jordan, Algeria, Austria, Egypt, Switzerland and Cape Verde. While France on the other hand have played teams like Norway, Morocco, Senegal, Sweden and Paraguay. Argentina somehow got the easiest fixture out of every big team. What an incredible coincidence. Let's see how they cope against their toughest opponents yet, England.
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Bigtomato
Bigtomato@Bigtomato22·
@Grandsoncr7 Just watch a video of him playing in his prime with Barcelona
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grandson
grandson@Grandsoncr7·
I’m genuinely afraid for Messi’s career. Everything he achieved will be attributed to robbery, corruption, and maximum FIFA support. When there are rankings of the greatest players of all time, he’s not going to be in the top five because his whole achievement was bought. Do you think Messi should be in the top five greatest of all time despite being involved in so many scandals?
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Diego
Diego@Trunkss23·
@mdiana017 Francia 2-0 o 2-1 a España Inglaterra 0-0 o 1-1 con Argentina Inglaterra debe mejorar su juego, sacar ventaja con sus físicos, rapidez y remates de afuera Ensaya penales, estudia los que siempre patean en hambrentina, la presión que mete el dibu
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Diana M
Diana M@mdiana017·
Mi pronóstico para la semifinal 🇫🇷 Francia 1 🇪🇸 España 0 🏴󠁧󠁢󠁥󠁮󠁧󠁿 Inglaterra 3 🇦🇷 Argentina 0 ¿Opiniones?
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9Del12XSiempre
9Del12XSiempre@9Del12XSiempre·
@mdiana017 sería muy inusual que argentina caiga por goleada en una semifinal, que la puede perder?, claro, pero de ahí a caer por goleada no creo, teniendo en cuenta que argentina nunca perdio una semifinal de mundial sería algo muy fuera de lo común que suceda.
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DAVIS LUXURY
DAVIS LUXURY@davis_luxury·
Hey @grok explain this to me like a 10 year old
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one②wan ⚡
one②wan ⚡@cmtglm·
@YourAnonOne The 2-1 score is just a compromise ; you pick a winner without too many goals (humility is a virtue) and give the loser one goal (humility is a virtue) 🙃.
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Anonymous
Anonymous@YourAnonOne·
AI predictions for the 2026 World Cup semi-finals. Claude: 🇫🇷 2 - 1 🇪🇸 🇦🇷 2 - 1 🏴󠁧󠁢󠁥󠁮󠁧󠁿 Gemini: 🇫🇷 2 - 1 🇪🇸 🇦🇷 2 - 1 🏴󠁧󠁢󠁥󠁮󠁧󠁿 ChatGPT: 🇫🇷 2 - 1 🇪🇸 🇦🇷 2 - 1 🏴󠁧󠁢󠁥󠁮󠁧󠁿 Grok: 🇫🇷 2 - 1 🇪🇸 🇦🇷 2 - 1 🏴󠁧󠁢󠁥󠁮󠁧󠁿
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Bigtomato
Bigtomato@Bigtomato22·
@bryan_johnson This is nothing more than the Blueprint protocol at work....IE, measure your biomarkers, and use the information to improve/ preserve your health as much as possible. Over 40, we all should be doing this!
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Bryan Johnson
Bryan Johnson@bryan_johnson·
Friends, no need to be sad about this. Amidst the noise, so many of you have been supportive and kind to me. I deeply appreciate your messages, posts of public support and private acts of kindness. I feel emboldened by the diagnosis. I want this challenge and I'm hungry for it. No amount of optimism can fully capture what awaits us and I'm glad to be on the same journey for those of you who believe the same.
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Bryan Johnson
Bryan Johnson@bryan_johnson·
The world wants me to die. My incurable disease diagnosis became global news. It was omnipresent on social media and 1,900 articles were written in a matter of days. Many were saddened. However, joy dominated the commentary. People pointed to schadenfreude, the pleasure of another's failure. Yes, there’s that. There is a special place in people’s hearts that loves to see others fail, especially when that person’s presence threatens their own psychological stability in some way or helps them feel better about themselves. But, if you look over the social media commentary about me, you’ll see that pattern: “he deserved it.” I deserved it because I challenged death. The crowd was running a deeply rooted psychological script that represents the oldest, most deeply embedded stories of human culture. This was the first story ever written down, 4,000 years ago. Gilgamesh sought eternal life after losing someone he loved, only to have the plant of youth stolen by a serpent as he bathed. Leaving him to accept his mortality. Asclepius became so skilled at rejuvenation that he raised the dead. As punishment, Zeus struck him down with a thunderbolt to enforce life and death authority. This is the story of Jesus. Pontius Pilate offered a choice between a thief and the immortalist, and the crowd demanded the execution. People need this story conclusion to keep themselves sane. The challenger must lose and the loss must appear deserved. It’s a shield of self preservation. For if death is inevitable, their existence and that of their loved ones is justified and unavoidable. If death is not inevitable, nothing about their reality is safe. I occupy the same philosophical and archetypal position as Gilgamesh, Asclepius and Jesus. This statement will draw outrage and accusations of blasphemy, hubris and narcissism. Nevertheless, it’s the pattern that has repeated itself for thousands of years. Death has been the omnipresent concern of the human race. It encapsulates our greatest fears, joy and curiosities. The discourse around it changes over time; however, the fundamentals remain unchanged. What’s different about this moment, that is unlike any other moment, is that physical death may no longer be inevitable. What if I didn’t deserve it? And what if I am your ally, and not a threat?
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Bigtomato
Bigtomato@Bigtomato22·
@Floydchels If it goes to penalties,El Dibu will sort things out!
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𝑭𝒍𝒐𝒚𝒅 ✨
𝑭𝒍𝒐𝒚𝒅 ✨@Floydchels·
🚨🎙️ Thierry Henry after Argentina beat Switzerland to qualify for the next round at the World Cup 🗣️ “You can see Messi can’t move the way he always moves. I’m sad, he’s getting old. I don’t think he will play in the next Copa America. He will probably retire after the World Cup. The players are fighting for him, he has already earned their respect, he’s not fighting for their respect like the other guy(Cristiano Ronaldo) Lionel Scaloni is not a great tactician, but the players respect him. I see them going to penalties against England. England are very bad at controlling the tempo of the game. The only players I love there are Kane, Jude and Reece. Anderson is good too, but I think Enzo will school him. It will be a tough match I love what FIFA did. They saw the fans complaining about refs supporting Argentina every game. Then FIFA intentionally brought a referee from Cristiano’s country and Messi still won. They are clearly favored by God not FIFA”. 👏
𝑭𝒍𝒐𝒚𝒅 ✨ tweet media𝑭𝒍𝒐𝒚𝒅 ✨ tweet media
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Bigtomato
Bigtomato@Bigtomato22·
@UnitedAlex7 England beat Mexico after it spilled rain, what's your point?
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Michael
Michael@michaelttfw·
World Cup GOAT - Mbappe Euros GOAT - Ronaldo Champions League GOAT - Ronaldo Messi can have the Copa del Rey or something.
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