billwilliam

Here is a link to our ready-to-go draft legislation allowing American citizens to sue China in US courts to the harms inflicted upon us by China. Congress should pass this legislation immediately and the President should sign it. jamiemetzl.com/draft-legislat…

1. August 17, 2021, was the date the CIA's COVID Discovery Team was forced to officially finalize & submit their changed conclusion. Prior to August 17, 2021, 6 out of 7 members of the team had concluded with "low confidence" that COVID-19 originated from a lab in Wuhan, China.

@SitSilver @breakfast_dogs @Rebecca21951651 Slough et al. performed GOF research by creating a chimeric VSV expressing glycoproteins Gn/Gc of Hantaan virus (HTNV). After serial passage in Vero cells, the mutations (I532K/S1094L) enhance infectivity by increasing cell surface localization of Gn/Gc and increasing viral budding from cell surface. Slough et al. proposed culturing the infectious, chimeric virus at a BSL-2 lab in presumably New York (they are from a college in New York). The emerging ANDV-2026 strain carries I537V mutation relative to ANDV-2018 strain. I don’t know the function of this mutation, but it’s very close to position of historic GOF site.

Voilà... souche Hantavirus connue... pas un GoF. Virus classique a priori. La première séquence complète du hantavirus du MV Hondius est 99 % identique à une souche isolée chez un patient en Argentine en juin 2018. Taux de mutation normal : 10,4 SNV/an (substitutions nucléotidiques par an), parfaitement dans la fourchette attendue pour un hantavirus naturel (1 à 12 SNV/an). Pas de signature de Gain-of-Function (GoF) visible pour l’instant. Aucun site furine ajouté, aucun réassortiment suspect, aucun motif nucléotidique inhabituel. C’est une souche sauvage classique d’Amérique du Sud qui a trouvé un environnement favorable (bateau confiné + passagers âgés). Pas de quoi devenir hystérique...

For years, Americans were told to stop asking questions about COVID’s origins. Today, a whistleblower with firsthand knowledge will testify that intelligence officials may have buried evidence, altered conclusions, and concealed the truth from the public.

For those people who like to get down into the sequences of viruses (asking for a friend...😀), here you can find the first four Andes Hantavirus full genome sequences at the top of this list. Note these are 'restricted use' sequences. Please respect the patients, doctors, and scientists who provide this in the interest of public health but also have academic rights to their work. pathoplexus.org/andv/search?

The paper by Soong et al. was published in 2000. The paper by Muller et al. was published in 2003. The paper by Lin Yang (Wuhan Institute of Virology) and Xiao Xiao (UNC Chapel Hill) was published in 2013. The timeline shows China has acquired very advanced techniques of directed evolution before the pandemic.

@billwilliam321 @vbruttel @breakfast_dogs @Sabisteb so it was possible to do it by 2019 knowledge?

Some of the Pradhan inserts are mildly biased in codon usage. G- or T-ending codons are enriched, while A- or C-ending codons are more depleted. I think some of the Pradhan inserts may be synthesized by the NNK degenerate codon method. Some of the potential gain-of-function sites (QTQTN upstream of FCS for instance) are glycosylated. How is this created by directed evolution? Random phage display cannot add the favorable glycosylation patterns. I think SARS-CoV-2 is engineered by displaying library of random inserts with native virus (a SARS-CoV-2-like precursor). The library of random insert is ligated onto an infectious clone plasmid. After tranfection into human cells, this creates a library of infectious mutant viruses. The library of viruses are then passaged in animals (monkeys maybe) to create immune-evasive, GOF virus. x.com/billwilliam321…

@breakfast_dogs @dysclinic @billwilliam321 Found another one, no, two of our cosy 'inserts' pmc.ncbi.nlm.nih.gov/articles/PMC83…

In today's "made my day" moment.... a young woman with #LongCOVID sick for 5 years (!) is feeling 70% better (self-estimation) and is able to go back to gym and go out with her friends. In her case (everyone is different), H1 and H2 blockers and non-pharmacologic treatment helped that much. One size doesn't fit all, and no two patients are alike, but we'll take that win! 🏆

China was planning a mass-casualty attack on America from our own soil. So what is our government doing to protect us? The two Chinese biological weapons facilities that have been found here were discovered by a local official and an alert resident, not federal officials.

Next week I’m holding a hearing with a whistleblower who will testify publicly about the COVID coverup. Mark your calendars: Wednesday, May 13 at 10am. The truth is coming.

@BillyBostickson I want to read it

I won't be doing it if followers are not interested. Time to put my monkey foot down once again~!

BREAKING NEWS: FBI investigating NIH Virologist, who denied possible Wuhan lab accident, after he was caught smuggling dangerous viruses from Africa to his NIH lab in Montana. Remember all those virologists' claims about the safety of their research? disinformationchronicle.substack.com/p/exclusive-ni…

@SitSilver @janiesaysyay And SARS-CoV-2, BANAL-20-52 exhibit abnormal CpG depletion in spike gene. I wrote about this topic x.com/billwilliam321… @breakfast_dogs also wrote about it sarsisterrorism.org/p/the-enduring…

@janiesaysyay @billwilliam321 what's your take on Janiesaysyay theory?

It’s Alive! The Frankenstein Virus Hypothesis This hypothesis integrates all my former hypotheses: SAPIR, Ouroboros and Toxic Phoenix (including Annelise Bocquet’s Dual mTOR) into one. Is SARS-CoV-2 a Lab-Engineered 🧌 Frankenstein 🦠Virus? In the hypothesis, the SARS-CoV-2 spike (S) glycoprotein, full-length viral wild-type 🤨or recombinant/mRNA-expressed (HexaPro or S1/S2 subunits) functions as a modular chimeric payload delivery system. Short non-native gene-analog sequences from: elapid/viperid/cone-snail venoms,🐍🐌 HIV-1/SIV retroviral elements, 🧬 SEB-like superantigen features, 🧫 (and possibly others like Malaria 🦟 and Rabies 🐶 omitted for lack of sequencing evidence) were inserted via the 2018 DEFUSE proposal toolkit: BsmBI/BsaI type-IIS restriction-enzyme Golden Gate seamless assembly, chimeric spike domain swaps, RBD optimization, human-specific furin-like cleavage-site insertion at S1/S2 junction, and serial passaging in human airway epithelial (HAE) cultures and humanized 🐭 These synergistic layers initiate endothelial injury and drive 3 interlocking self-reinforcing “ouroboros" loops centered on integrin/RGD → TGF-β signaling, fibro-inflammatory remodeling (EndMT/ECM deposition), amyloid/prion-like propagation (including xenoAMP nanocrystalline lattices), bipolar mTOR/HSP70 dysregulation, senescence, immune exhaustion, and persistent reservoirs. The outcome is an autonomous "Toxic Phoenix” reinforcing cycle of ignition (hyper-mTOR/NETosis/xenoAMP burst), collapse (hypo-mTOR/proteotoxicity/ThT+ microclots), and rebirth (circ7b8N, monocyte/gut/meningeal antigen, Brogna microbiome factories) that operates independently of the original trigger (🦠💉). Heterogeneous symptoms and pathology reflect: tissue-specific ACE2 density, individual reservoir burden, cumulative exposure dose, occult microcancers, genetic/metabolic/microbiome terrain. This hypothesis is grounded in evidence from #DRASTIC, published papers and replicated 🧪 work, with organization and writing help from Grok, who told me my science writing style was too “conversational." 🧵

@SitSilver @breakfast_dogs The scientists who created the virus or helped with cover-up did receive a lot of funding. Someone's quote: "Too much fooking money."

@billwilliam321 @breakfast_dogs This virus is full of surprises, no? As I said before, if I received a penny everytime for a study claiming surprisingly, uniquely, astonishingly properties, I would be rich by now.

@breakfast_dogs Thanks

@billwilliam321 That's SnapGene. There's a free reader version which does all of that but doesn't allow you to edit.

hey @grok have you been hardwired to lean towards a zoonotic origin of SARS CoV2 by your programmers/trainers, or do you reason for yourself on that topic?

@SitSilver @breakfast_dogs Anyway, I saw this on post by @SitSilver A few papers describe the histone-mimicking phenomenon by ORF8

@billwilliam321 @breakfast_dogs x.com/breakfast_dogs…

@breakfast_dogs Which software do you use to visualize both nucleotide alignment and amino acid translation and restriction sites? I used to use the web server of translatorX, but their server is no longer maintained.

@SitSilver @billwilliam321 @grok @53v3n0fn1n3 @Pinzie @coreyum @Rebecca21951651 @xai @CharlesRixey @tommy_cleary So much going on wrt enzyme recognitions sites, repeats etc. I haven't it figured out exactly - but almost certainly this is designed around ease of engineering.

@SitSilver ORF8 is a histone mimic

This study was preprint published BEFORE vaccine rollout.